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Control of defense mechanism in the small intestinal mucosa via Aryl Hydrocarbon Receptor

Research Project

Project/Area Number 18K07908
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Sugimoto Ken  浜松医科大学, 医学部, 教授 (20529507)

Co-Investigator(Kenkyū-buntansha) 大澤 恵  浜松医科大学, 医学部附属病院, 講師 (10397391)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords難治性小腸潰瘍 / IL-22 / 粘膜防御機構 / 小腸粘膜防御機構 / AhR
Outline of Final Research Achievements

In this study, in order to analyze the crosstalk between IL-22 and aromatic hydrocarbon receptor (AhR), IL-22 is induced in the mucosa of the small intestine of mice by stimulation with AhR-activator including curcumin, and the involvement in defense mechanisms of small intestinal epithelial cells (IEC) was observed. In addition, after stimulating small intestinal intraepithelial lymphocytes (IEL) with AhR-activator to induce IL-22 production, IEL and IEC were co-cultured and the expression of substances involved in STAT3 activation and mucosal defense in IEC was analyzed. Furthermore, the mechanism of regulating cytokine production in the mouse small intestine by administration of AhR-activator in vivo and the mechanism of mucosal defense against IEC were analyzed.

Academic Significance and Societal Importance of the Research Achievements

現在脳梗塞や心筋梗塞予防のためアスピリンなどの血栓予防薬の内服が必要な患者が存在するが、これらの薬剤が小腸に障害を来し、難治性の小腸潰瘍を引き起こしてしまうことがある。今回我々は自然界に存在し食材としても使用できる安全な物質であるクルクミンが、小腸に存在するリンパ球からIL-22というサイトカインを産生することで、小腸粘膜を防御するかどうかについて、マウスの実験モデルを使用して証明することを試みた。これらの研究によりクルクミンの小腸粘膜防御作用が証明されれば、血栓予防薬内服患者の小腸潰瘍を予防したり、治療したりすることが可能になる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (38 results)

All 2021 2020 2019 2018

All Journal Article (32 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 32 results,  Open Access: 13 results) Presentation (6 results) (of which Invited: 1 results)

  • [Journal Article] Evaluation of the modified Crohn's disease activity index in patients with Crohn disease with enterostomy2021

    • Author(s)
      Ishida Natsuki、Miyazu Takahiro、Suzuki Takahiro、Tamura Satoshi、Tani Shinya、Yamade Mihoko、Hamaya Yasushi、Iwaizumi Moriya、Osawa Satoshi、Furuta Takahisa、Sugimoto Ken
    • Journal Title

      Medicine

      Volume: 100 Issue: 6 Pages: e24717-e24717

    • DOI

      10.1097/md.0000000000024717

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prostaglandin E-Major Urinary Metabolite Predicts Relapse in Patients With Ulcerative Colitis in Clinical Remission2020

    • Author(s)
      Ishida Natsuki、Sugiura Kiichi、Miyazu Takahiro、Tamura Satoshi、Suzuki Satoshi、Tani Shinya、Yamade Mihoko、Iwaizumi Moriya、Hamaya Yasushi、Osawa Satoshi、Furuta Takahisa、Sugimoto Ken
    • Journal Title

      Clinical and Translational Gastroenterology

      Volume: 11 Issue: 12 Pages: e00289-e00289

    • DOI

      10.14309/ctg.0000000000000289

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tuberous sclerosis patient with neuroendocrine carcinoma of the esophagogastric junction: A case report2020

    • Author(s)
      Ishida Natsuki、Miyazu Takahiro、Tamura Satoshi、Suzuki Satoshi、Tani Shinya、Yamade Mihoko、Iwaizumi Moriya、Osawa Satoshi、Hamaya Yasushi、Shinmura Kazuya、Sugimura Haruhiko、Miura Katsutoshi、Furuta Takahisa、Sugimoto Ken
    • Journal Title

      World Journal of Gastroenterology

      Volume: 26 Issue: 45 Pages: 7263-7271

    • DOI

      10.3748/wjg.v26.i45.7263

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mesalazine granule formulation improves clinical data in Crohn's disease compared with tablet formulation2020

    • Author(s)
      Tamura Satoshi、Ishida Natsuki、Miyazu Takahiro、Onoue Shunya、Tani Shinya、Yamade Mihoko、Hamaya Yasushi、Iwaizumi Moriya、Osawa Satoshi、Furuta Takahisa、Sugimoto Ken
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 21353-21353

    • DOI

      10.1038/s41598-020-78603-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The first evidence for SLFN11 expression as an independent prognostic factor for patients with esophageal cancer after chemoradiotherapy2020

    • Author(s)
      Kagami Takuma、Yamade Mihoko、Suzuki Takahiro、Uotani Takahiro、Tani Shinya、Hamaya Yasushi、Iwaizumi Moriya、Osawa Satoshi、Sugimoto Ken、Miyajima Hiroaki、Baba Satoshi、Sugimura Haruhiko、Murai Junko、Pommier Yves、Furuta Takahisa
    • Journal Title

      BMC Cancer

      Volume: 20 Issue: 1 Pages: 1123-1123

    • DOI

      10.1186/s12885-020-07574-x

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] ‘Four-position method’ makes beginner endoscopists aware of spatial positioning of the left hand to master upper gastrointestinal endoscopy2020

    • Author(s)
      Sugimoto Ken、Osawa Satoshi
    • Journal Title

      Endoscopy International Open

      Volume: 08 Issue: 10 Pages: E1225-E1230

    • DOI

      10.1055/a-1197-6418

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Microsatellite frameshift variants in SGO1 of gastric cancer are not always associated with MSI status2020

    • Author(s)
      http://orcid.org/0000-0001-5601-4741Tomohiro Sugiyama, Moriya Iwaizumi, Terumi Taniguchi, Satoshi Suzuki, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Hiroaki Miyajima, Tsutomu Ohta, Satoshi Baba, Haruhiko Sugimura, Masato Maekawa, Ken Sugimoto
    • Journal Title

      Journal of clinical pathology

      Volume: 73 Issue: 6 Pages: 206934-206934

    • DOI

      10.1136/jclinpath-2020-206934

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improvement in Ulcerative Colitis by Administration of Benralizumab for Comorbid Refractory Bronchial Asthma: A Novel Clinical Observation2020

    • Author(s)
      Sugimoto Ken、Fujita Shoya、Miyazu Takahiro、Ishida Natsuki、Tani Shinya、Yamade Mihoko、Hamaya Yasushi、Iwaizumi Moriya、Furuta Takahisa、Osawa Satoshi
    • Journal Title

      Inflammatory Bowel Diseases

      Volume: 27 Issue: 1 Pages: e3-e4

    • DOI

      10.1093/ibd/izaa225

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection.2020

    • Author(s)
      Sugiyama T, Iwaizumi M, Kaneko M, Tani S, Yamade M, Hamaya Y, Furuta T, Miyajima H, Osawa S, Baba S, Maekawa M, Sugimoto K
    • Journal Title

      Oncol Lett.

      Volume: 20 Issue: 3 Pages: 2435-2441

    • DOI

      10.3892/ol.2020.11799

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effect of early trough level of infliximab on subsequent disease course in patients with Crohn disease2020

    • Author(s)
      Ishida Natsuki、Miyazu Takahiro、Sugiyama Tomohiro、Tamura Satoshi、Kagami Takuma、Tani Shinya、Yamade Mihoko、Iwaizumi Moriya、Hamaya Yasushi、Osawa Satoshi、Furuta Takahisa、Sugimoto Ken
    • Journal Title

      Medicine

      Volume: 99 Issue: 29 Pages: e21226-e21226

    • DOI

      10.1097/md.0000000000021226

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of ulcerative colitis duration on the usefulness of immunochemical fecal occult blood test result as a disease activity biomarker2020

    • Author(s)
      Ishida Natsuki、Miyazu Takahiro、Matsuura Tomoharu、Takano Ryosuke、Tamura Satoshi、Kagami Takuma、Tani Shinya、Yamade Mihoko、Hamaya Yasushi、Iwaizumi Moriya、Osawa Satoshi、Furuta Takahisa、Sugimoto Ken
    • Journal Title

      International Journal of Colorectal Disease

      Volume: 35 Issue: 9 Pages: 1729-1739

    • DOI

      10.1007/s00384-020-03636-5

    • NAID

      120007038338

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photodynamic Therapy Using Talaporfin Sodium for Local Failure after Chemoradiotherapy or Radiotherapy for Esophageal Cancer: A Single Center Experience2020

    • Author(s)
      Ishida Natsuki、Osawa Satoshi、Miyazu Takahiro、Kaneko Masanao、Tamura Satoshi、Tani Shinya、Yamade Mihoko、Iwaizumi Moriya、Hamaya Yasushi、Furuta Takahisa、Sugimoto Ken
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 5 Pages: 1509-1509

    • DOI

      10.3390/jcm9051509

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly bioavailable curcumin derivative ameliorates Crohn's disease symptoms: A randomized, double-blind, multicenter study2020

    • Author(s)
      Sugimoto K, Ikeya K, Bamba S, Andoh A, Yamasaki H, Mitsuyama K, Nasuno M, Tanaka H, Matsuura A, Kato M, Ishida N, Tamura S, Takano R, Tani S, Osawa S, Nishihira J, Hanai H
    • Journal Title

      Journal of Crohns & Colitis

      Volume: 14 Issue: 12 Pages: 1693-1701

    • DOI

      10.1093/ecco-jcc/jjaa097

    • NAID

      120007038337

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prostaglandin E-major urinary metabolite versus fecal immunochemical occult blood test as a biomarker for patient with ulcerative colitis2020

    • Author(s)
      Ishida Natsuki、Miyazu Takahiro、Takano Ryosuke、Tamura Satoshi、Tani Shinya、Kagami Takuma、Yamade Mihoko、Hamaya Yasushi、Iwaizumi Moriya、Osawa Satoshi、Furuta Takahisa、Miyajima Hiroaki、Sugimoto Ken
    • Journal Title

      BMC Gastroenterology

      Volume: 20 Issue: 1 Pages: 114-114

    • DOI

      10.1186/s12876-020-01256-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of clarithromycin on the bactericidal effect of amoxicillin in patients infected with clarithromycin-resistant strains of H. pylori2020

    • Author(s)
      Furuta Takahisa、Yamade Mihoko、Kagami Takuma、Suzuki Takahiro、Higuchi Tomohiro、Tani Shinya、Hamaya Yasushi、Iwaizumi Moriya、Miyajima Hiroaki、Umemura Kazuo、Osawa Satoshi、Sugimoto Ken
    • Journal Title

      Gut

      Volume: 69 Issue: 11 Pages: 2056.2-2056

    • DOI

      10.1136/gutjnl-2020-320705

    • NAID

      120006993589

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A rare lesion at the ileostomy site of a patient with intestinal Beh?et's disease2020

    • Author(s)
      Hirano Yuichi、Miyazu Takahiro、Sugimoto Ken
    • Journal Title

      Gastroenterology

      Volume: - Issue: 1 Pages: e14-e15

    • DOI

      10.1053/j.gastro.2019.12.037

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dual Therapy with Vonoprazan and Amoxicillin Is as Effective as Triple Therapy with Vonoprazan, Amoxicillin and Clarithromycin for Eradication of Helicobacter pylori2019

    • Author(s)
      Furuta Takahisa、Yamade Mihoko、Kagami Takuma、Uotani Takahiro、Suzuki Takahiro、Higuchi Tomohiro、Tani Shinya、Hamaya Yasushi、Iwaizumi Moriya、Miyajima Hiroaki、Umemura Kazuo、Osawa Satoshi、Sugimoto Ken
    • Journal Title

      Digestion

      Volume: 21 Issue: 6 Pages: 1-9

    • DOI

      10.1159/000502287

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Decompressive laparotomy for abdominal compartment syndrome resulting from severe acute pancreatitis: a case report2019

    • Author(s)
      Ikeda Shinya、Kagami Takuma、Tani Shinya、Uotani Takahiro、Yamade Mihoko、Hamaya Yasushi、Morita Yoshifumi、Sakaguchi Takanori、Osawa Satoshi、Sugimoto Ken
    • Journal Title

      BMC Gastroenterology

      Volume: 19 Issue: 1

    • DOI

      10.1186/s12876-019-1059-0

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rectal neuroendocrine tumor in a patient with Crohn’s disease: a case report and literature review2019

    • Author(s)
      Suzuki Katsunori、Yamamoto Masayoshi、Suzuki Yuhi、Kawamura Takafumi、Kamishima Megumu、Sakata Mayu、Harada Takashi、Kagami Takuma、Tani Shinya、Yamade Mihoko、Hamaya Yasushi、Osawa Satoshi、Sugimoto Ken、Kurachi Kiyotaka、Takeuchi Hiroya
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: 13 Issue: 3 Pages: 320-327

    • DOI

      10.1007/s12328-019-01063-w

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Utility of Scanning Electron Microscopy Elemental Analysis Using the ‘NanoSuit’ Correlative Light and Electron Microscopy Method in the Diagnosis of Lanthanum Phosphate Deposition in the Esophagogastroduodenal Mucosa2019

    • Author(s)
      Shinmura Kazuya、Kawasaki Hideya、Baba Satoshi、Ohta Isao、Kato Hisami、Yasuda Hideo、Yamada Satoshi、Misawa Kiyoshi、Sugimoto Ken、Osawa Satoshi、Sato Masanori、Hariyama Takahiko、Sugimura Haruhiko
    • Journal Title

      Diagnostics

      Volume: 10 Issue: 1 Pages: 1-1

    • DOI

      10.3390/diagnostics10010001

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Management of elderly ulcerative colitis in Japan2019

    • Author(s)
      Higashiyama Masaaki、Sugita Akira、Koganei Kazutaka、Wanatabe Kenji、Yokoyama Yoko、Uchino Motoi、Nagahori Masakazu、Naganuma Makoto、Bamba Shigeki、Kato Shingo、Takeuchi Ken、Omori Teppei、Takagi Tomohisa、Matsumoto Satohiro、Nagasaka Mitsuo、Sagami Shintaro、Kitamura Kazuya、Katsurada Takehiko、Sugimoto Ken、et al.
    • Journal Title

      Journal of Gastroenterology

      Volume: 54 Issue: 7 Pages: 571-586

    • DOI

      10.1007/s00535-019-01580-y

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Eradication therapy for <i>Helicobacter pylori</i> infection improves nutrition status in Japanese hemodialysis patients: a pilot study2019

    • Author(s)
      Ichikawa H, Sugimoto M, Sakao Y, Sahara S, Ohashi N, Sano K, Tadokoro S, Azekura H, Shimomura A, Yamashita F, Sugiyama D, Fukuta K, Furuta T, Kato A, Sugimoto K, Yasuda H
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 64 Issue: 1 Pages: 91-95

    • DOI

      10.3164/jcbn.18-61

    • NAID

      130007542264

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Assessment of Long-Term Efficacy and Safety of Adalimumab in Patients with Ulcerative Colitis: Results from a 6-Year Real-World Clinical Practice2018

    • Author(s)
      Sugimoto Ken、Ikeya Kentaro、Kato Masaichi、Matsuura Ai、Watanabe Fumitoshi、Takano Ryosuke、Tamura Satoshi、Tani Shinya、Osawa Satoshi、Hanai Hiroyuki
    • Journal Title

      Digestive Diseases

      Volume: 37 Issue: 1 Pages: 11-20

    • DOI

      10.1159/000493121

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluating mucosal healing using colon capsule endoscopy predicts outcome in patients with ulcerative colitis in clinical remission2018

    • Author(s)
      Takano Ryosuke、Osawa Satoshi、Uotani Takahiro、Tani Shinya、Ishida Natsuki、Tamura Satoshi、Yamade Mihoko、Iwaizumi Moriya、Hamaya Yasushi、Furuta Takahisa、Miyajima Hiroaki、Sugimoto Ken
    • Journal Title

      World Journal of Clinical Cases

      Volume: 6 Issue: 15 Pages: 952-960

    • DOI

      10.12998/wjcc.v6.i15.952

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Prevalence of elevated microsatellite alterations at selected tetranucleotide repeats in pancreatic ductal adenocarcinoma2018

    • Author(s)
      Mori Taiki、Hamaya Yasushi、Uotani Takahiro、Yamade Mihoko、Iwaizumi Moriya、Furuta Takahisa、Miyajima Hiroaki、Osawa Satoshi、Sugimoto Ken
    • Journal Title

      PLOS ONE

      Volume: 13 Issue: 12 Pages: e0208557-e0208557

    • DOI

      10.1371/journal.pone.0208557

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] High expression level of CD44v8-10 in cancer stem-like cells is associated with poor prognosis in esophageal squamous cell carcinoma patients treated with chemoradiotherapy2018

    • Author(s)
      Kagami Takuma、Yamade Mihoko、Suzuki Takahiro、Uotani Takahiro、Tani Shinya、Hamaya Yasushi、Iwaizumi Moriya、Osawa Satoshi、Sugimoto Ken、Baba Satoshi、Sugimura Haruhiko、Miyajima Hiroaki、Furuta Takahisa
    • Journal Title

      Oncotarget

      Volume: 9 Issue: 79 Pages: 34876-34888

    • DOI

      10.18632/oncotarget.26172

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Gender Differences in Plasma Ghrelin Levels in Hemodialysis Patients2018

    • Author(s)
      Sakao Yukitoshi、Ohashi Naro、Sugimoto Mitsushige、Ichikawa Hitomi、Sahara Shu、Tsuji Takayuki、Kato Akihiko、Fujigaki Yoshihide、Sugimoto Ken、Furuta Takahisa、Yasuda Hideo
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 23 Issue: 1 Pages: 65

    • DOI

      10.1111/1744-9987.12764

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A multicenter retrospective study aiming to identify patients who respond well to adsorptive granulomonocytapheresis in moderately to severely active ulcerative colitis2018

    • Author(s)
      Yamamoto Takayuki、Iida Takayuki、Ikeya Kentaro、Kato Masaichi、Matsuura Ai、Tamura Satoshi、Takano Ryosuke、Tani Shinya、Osawa Satoshi、Sugimoto Ken、Shimoyama Takahiro、Hanai Hiroyuki
    • Journal Title

      Clinical and Translational Gastroenterology

      Volume: 9 Issue: 7 Pages: e170-e170

    • DOI

      10.1038/s41424-018-0037-0

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] New 14-mm diameter Niti-S biliary uncovered metal stent for unresectable distal biliary malignant obstruction2018

    • Author(s)
      Kikuyama Masataka、Shirane Naofumi、Kawaguchi Shinya、Terada Shuzou、Mukai Tsuyoshi、Sugimoto Ken
    • Journal Title

      World Journal of Gastrointestinal Endoscopy

      Volume: 10 Issue: 1 Pages: 16-22

    • DOI

      10.4253/wjge.v10.i1.16

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Efficacy of Reduced Dosage of Amoxicillin in an Eradication Therapy for <b><i>Helicobacter pylori</i></b> Infection in Patients on Hemodialysis: A Randomized Controlled Trial2018

    • Author(s)
      Sahara Shu、Sugimoto Mitsushige、Ichikawa Hitomi、Kagami Takuma、Sakao Yukitoshi、Ohashi Naro、Horio Yoshiaki、Sugimoto Ken、Kato Akihiko、Furuta Takahisa、Yasuda Hideo
    • Journal Title

      Digestion

      Volume: 97 Issue: 2 Pages: 163-169

    • DOI

      10.1159/000484981

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A Rare Cause of a Rectal Tumor-like Lesion2018

    • Author(s)
      Sugimoto Ken、Shimura Eri、Osawa Satoshi
    • Journal Title

      Gastroenterology

      Volume: 154 Issue: 8 Pages: 2039-2040

    • DOI

      10.1053/j.gastro.2017.09.016

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative Study of Effects of Vonoprazan and Esomeprazole on Antiplatelet Function of Clopidogrel or Prasugrel in Relation to CYP2C19 Genotype.2018

    • Author(s)
      Kagami T, Yamade M, Suzuki T, Uotani T, Hamaya Y, Iwaizumi M, Osawa S, Sugimoto K, Umemura K, Miyajima H, Furuta T.
    • Journal Title

      Clin Pharmacol Ther.

      Volume: 103 Issue: 5 Pages: 906-913

    • DOI

      10.1002/cpt.863

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 当院における難治性潰瘍性大腸炎に対するトファシチニブの有用性について2021

    • Author(s)
      杉本健
    • Organizer
      第75回日本大腸肛門病学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] HIGHLY BIOAVAILABLE CURCUMIN(THERACURMIN) FOR CROHN'S DISEASE: RANDOMIZED, MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL2019

    • Author(s)
      Ken Sugimoto
    • Organizer
      JDDW2019
    • Related Report
      2019 Research-status Report
  • [Presentation] 炎症性腸疾患診療の現状と今後2019

    • Author(s)
      杉本健
    • Organizer
      日本消化器病学会東海支部例会
    • Related Report
      2019 Research-status Report
  • [Presentation] クローン病患者におけるインフリキシマブ導入後14週目の血中トラフ濃度がその後の臨床経過に及ぼす影響について2019

    • Author(s)
      杉本健
    • Organizer
      第105回日本消化器病学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 実臨床データから見えた潰瘍性大腸炎治療のポイント2019

    • Author(s)
      杉本健
    • Organizer
      第15回日本消化管学会総会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 5ASA製剤の錠剤から顆粒製剤への変更がクローン病患者の長期的な臨床成績に及ぼす影響について2019

    • Author(s)
      杉本健
    • Organizer
      第15回日本消化管学会総会学術集会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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