Control of defense mechanism in the small intestinal mucosa via Aryl Hydrocarbon Receptor
Project/Area Number |
18K07908
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53010:Gastroenterology-related
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
Sugimoto Ken 浜松医科大学, 医学部, 教授 (20529507)
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Co-Investigator(Kenkyū-buntansha) |
大澤 恵 浜松医科大学, 医学部附属病院, 講師 (10397391)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 難治性小腸潰瘍 / IL-22 / 粘膜防御機構 / 小腸粘膜防御機構 / AhR |
Outline of Final Research Achievements |
In this study, in order to analyze the crosstalk between IL-22 and aromatic hydrocarbon receptor (AhR), IL-22 is induced in the mucosa of the small intestine of mice by stimulation with AhR-activator including curcumin, and the involvement in defense mechanisms of small intestinal epithelial cells (IEC) was observed. In addition, after stimulating small intestinal intraepithelial lymphocytes (IEL) with AhR-activator to induce IL-22 production, IEL and IEC were co-cultured and the expression of substances involved in STAT3 activation and mucosal defense in IEC was analyzed. Furthermore, the mechanism of regulating cytokine production in the mouse small intestine by administration of AhR-activator in vivo and the mechanism of mucosal defense against IEC were analyzed.
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Academic Significance and Societal Importance of the Research Achievements |
現在脳梗塞や心筋梗塞予防のためアスピリンなどの血栓予防薬の内服が必要な患者が存在するが、これらの薬剤が小腸に障害を来し、難治性の小腸潰瘍を引き起こしてしまうことがある。今回我々は自然界に存在し食材としても使用できる安全な物質であるクルクミンが、小腸に存在するリンパ球からIL-22というサイトカインを産生することで、小腸粘膜を防御するかどうかについて、マウスの実験モデルを使用して証明することを試みた。これらの研究によりクルクミンの小腸粘膜防御作用が証明されれば、血栓予防薬内服患者の小腸潰瘍を予防したり、治療したりすることが可能になる。
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Microsatellite frameshift variants in SGO1 of gastric cancer are not always associated with MSI status2020
Author(s)
http://orcid.org/0000-0001-5601-4741Tomohiro Sugiyama, Moriya Iwaizumi, Terumi Taniguchi, Satoshi Suzuki, Shinya Tani, Mihoko Yamade, Yasushi Hamaya, Satoshi Osawa, Takahisa Furuta, Hiroaki Miyajima, Tsutomu Ohta, Satoshi Baba, Haruhiko Sugimura, Masato Maekawa, Ken Sugimoto
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Journal Title
Journal of clinical pathology
Volume: 73
Issue: 6
Pages: 206934-206934
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] DNA mismatch repair is not disrupted in stage 0 colorectal cancer resected using endoscopic submucosal dissection.2020
Author(s)
Sugiyama T, Iwaizumi M, Kaneko M, Tani S, Yamade M, Hamaya Y, Furuta T, Miyajima H, Osawa S, Baba S, Maekawa M, Sugimoto K
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Journal Title
Oncol Lett.
Volume: 20
Issue: 3
Pages: 2435-2441
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Highly bioavailable curcumin derivative ameliorates Crohn's disease symptoms: A randomized, double-blind, multicenter study2020
Author(s)
Sugimoto K, Ikeya K, Bamba S, Andoh A, Yamasaki H, Mitsuyama K, Nasuno M, Tanaka H, Matsuura A, Kato M, Ishida N, Tamura S, Takano R, Tani S, Osawa S, Nishihira J, Hanai H
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Journal Title
Journal of Crohns & Colitis
Volume: 14
Issue: 12
Pages: 1693-1701
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Eradication therapy for <i>Helicobacter pylori</i> infection improves nutrition status in Japanese hemodialysis patients: a pilot study2019
Author(s)
Ichikawa H, Sugimoto M, Sakao Y, Sahara S, Ohashi N, Sano K, Tadokoro S, Azekura H, Shimomura A, Yamashita F, Sugiyama D, Fukuta K, Furuta T, Kato A, Sugimoto K, Yasuda H
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Journal Title
Journal of Clinical Biochemistry and Nutrition
Volume: 64
Issue: 1
Pages: 91-95
DOI
NAID
ISSN
0912-0009, 1880-5086
Related Report
Peer Reviewed
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[Journal Article] Comparative Study of Effects of Vonoprazan and Esomeprazole on Antiplatelet Function of Clopidogrel or Prasugrel in Relation to CYP2C19 Genotype.2018
Author(s)
Kagami T, Yamade M, Suzuki T, Uotani T, Hamaya Y, Iwaizumi M, Osawa S, Sugimoto K, Umemura K, Miyajima H, Furuta T.
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Journal Title
Clin Pharmacol Ther.
Volume: 103
Issue: 5
Pages: 906-913
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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