The role of B cell activating factor in liver fibrosis of fatty liver disease
| Project/Area Number |
18K07911
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Ehime University |
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Principal Investigator |
Abe Masanori 愛媛大学, 医学系研究科, 准教授 (40432786)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 脂肪性肝疾患 / 肝線維化 / アディポカイン / マクロファージ / サイトカイン |
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| Outline of Final Research Achievements |
In this study, we analyzed the role of B cell-activating factor (BAFF) in the fibrosis progression of fatty liver disease using BAFF-knockout (BAFF-KO) mice. We established mouse model with steatosis and fibrosis by feeding with high fat-high cholesterol diet and administration of carbon tetrachloride. Hepatic steatosis, inflammation and fibrosis was ameliorated in BAFF-KO mice compared with wild-type mice. The number of M1-like macrophages and M1/M2 ratio were significantly lower in BAFF-KO mice than in wild-type mice. These findings suggest that BAFF may contribute to the M1-like macrophage-dominant phenotype and the subsequent liver inflammation and fibrosis in fatty liver disease.
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| Academic Significance and Societal Importance of the Research Achievements |
多くの疫学研究から、肝炎ウイルス非感染者からの肝発癌の多くが、肥満や糖尿病などの代謝異常を合併していることが明らかとなっており、非常に多数の肥満、糖尿病患者の中から肝病態進行例を抽出すること、またその治療戦略を確立する必要がある。申請者はアディポカインであるBAFFが肥満・糖尿病と免疫異常・発癌を繋ぐ重要な因子の一つではないかと考えており、消化器病学のみならず、代謝および免疫の両者の観点から発展が期待される特色のある研究であり、本研究成果は脂肪性肝疾患のみならず、肥満関連疾患や臓器線維化などの領域に波及することが期待される。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Advanced fibrosis of non-alcoholic steatohepatitis affects the significance of lipoprotein(a) as a cardiovascular risk factor2020
Author(s)
Konishi K, Miyake T, Furukawa S, Senba H, Kanzaki S, Nakaguchi H, Yukimoto A, Nakamura Y, Watanabe T, Koizumi Y, Yoshida O, Tokumoto Y, Hirooka M, Kumagi T, Abe M, Matsuura B, Hiasa Y.
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Journal Title
Atherosclerosis
Volume: 299
Pages: 32-37
DOI
Related Report
Peer Reviewed
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[Journal Article] The Serum Creatinine Level Might Be Associated with the Onset of Impaired Fasting Glucose: A Community-based Longitudinal Cohort Health Checkup Study2019
Author(s)
Yoshida N, Miyake T, Yamamoto S, Furukawa S, Senba H, Kanzaki S, Koizumi M, Ishihara T, Yoshida O, Hirooka M, Kumagi T, Abe M, Kitai K, Matsuura B, Hiasa Y
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Journal Title
Internal Medicine
Volume: 58
Issue: 4
Pages: 505-510
DOI
NAID
ISSN
0918-2918, 1349-7235
Year and Date
2019-02-15
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] B-cell activating factor deficiency improves hepatic steatosis in a non-alcoholic fatty liver disease mouse model2018
Author(s)
Nakamura Y, Abe M, Sunago K, Yukimoto A, Imai Y, Tanaka T, Watanabe T, Koizumi Y, Yoshida O, Hirooka M, Hiasa Y
Organizer
AASLD Liver Meeting 2018
Related Report
Int'l Joint Research
