| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
In this study, we analyzed the role of B cell-activating factor (BAFF) in the fibrosis progression of fatty liver disease using BAFF-knockout (BAFF-KO) mice. We established mouse model with steatosis and fibrosis by feeding with high fat-high cholesterol diet and administration of carbon tetrachloride. Hepatic steatosis, inflammation and fibrosis was ameliorated in BAFF-KO mice compared with wild-type mice. The number of M1-like macrophages and M1/M2 ratio were significantly lower in BAFF-KO mice than in wild-type mice. These findings suggest that BAFF may contribute to the M1-like macrophage-dominant phenotype and the subsequent liver inflammation and fibrosis in fatty liver disease.
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