| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
We performed basic and clinical studies about eosinophilic esophagitis (EoE), and obtained the following research results: 1) IgE-mediated allergic sensitization patterns are associated with clinical features of patients with EoE. 2) Patients with asymptomatic EoE have similar histopathological esophageal inflammation. 3) Obesity and hiatal hernia may be non-allergic risk factors for EoE. 4) Barrett’s esophagus is negatively associated with EoE in Japanese subjects. 5) Presence of reflux esophagitis and absence of rings on endoscopy especially during GI screening, and localized EoE might be significant predictive factors for PPI response. 6) Vonoprazan showed similar efficacy to PPIs in EoE. 7) Several unique endoscopic findings of gastric lesions were observed in patients with gastric lesions of EGID. 8) Japanese data of EoE were reviewed and current therapeutic strategy of EoE, and ultimately proposes symptom-based diagnostic approach for EoE.
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