• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Intestinal microbiota as a therapeutic target of primary sclerosing cholangitis

Research Project

Project/Area Number 18K07931
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Kobayashi Yuka  東京大学, 医学部附属病院, 助教 (80724658)

Co-Investigator(Kenkyū-buntansha) 中川 勇人  東京大学, 医学部附属病院, 助教 (00555609)
木下 裕人  公益財団法人朝日生命成人病研究所, その他部局等, 教授(移行) (50645322)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords胆管炎 / 炎症性腸疾患 / 小腸 / 腸内細菌叢 / 硬化性胆管炎 / 潰瘍性大腸炎 / 原発性硬化性胆管炎 / 腸内フローラ
Outline of Final Research Achievements

Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease causing periductal fibrosis and ductal stenosis. PSC is sometimes accompanied with ulcerative colitis, but the pathogenesis is largely unknown and the treatment is not established. In this study, we examined the role of intestinal microbiota on the pathogenesis of PSC as well as gut-liver axis using PSC and colitis mouse model. Administration of antibiotics to different murine cholangitis model ameliorated the phenotype of cholangitis, such as leukocyte infiltration, fibrosis, and cytokine production. Antibiotic treatment reduced total bacterial number in feces and improved colonic inflammation. These results suggest the critical role of intestinal microbiota on the pathogenesis of PSC and ulcerative colitis.

Academic Significance and Societal Importance of the Research Achievements

原発性硬化性胆管炎は原因不明であり、治療法も確立していない難病である。マウスモデルを用いて胆管炎と腸炎を調節する因子として腸内フローラに着目して検討し、抗生剤による腸内フローラの改変が胆管炎を減弱させることが明らかになった。今後病態に関与する特定の細菌の同定やその制御法を開発することで、原発性硬化性胆管炎の治療が期待できる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results)

  • [Presentation] 原発性硬化性胆管炎における腸内細菌叢の役割解明と新規治療法の開発2019

    • Author(s)
      木下裕人、平田喜裕
    • Organizer
      東京大学医科学研究所国際共同研究拠点成果報告会
    • Related Report
      2018 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2022-12-28  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi