| Project/Area Number |
18K07937
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Mie University |
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Principal Investigator |
Yamada Reiko 三重大学, 医学部, 助教 (80571629)
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|---|
| Co-Investigator(Kenkyū-buntansha) |
笠原 広介 三重大学, 医学系研究科, 准教授 (90455535)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 一次線毛 / KRAS変異 / USP8 / 膵癌 / KRAS / EGFR抗体 |
|---|
| Outline of Final Research Achievements |
In cells of locally advanced pancreatic cancer that underwent preoperative chemoradiotherapy (CRT), it was confirmed that the primary cilia which had once disappeared were re-recognized after CRT. The formation of primary cilia is thought to have an inhibitory effect on cell proliferation. The presence or absence of primary cilia in pancreatic cancer cells will be determined and will be examined expression of Hh signaling, using pancreatic cancer excised specimens of patients who underwent CRT and underwent surgery.
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| Academic Significance and Societal Importance of the Research Achievements |
術前放射線化学療法 (NCRT) を施行した局所進行膵癌の細胞において、一旦消失した一次線毛がCRT後に再度認められる現象を確認した。膵癌で一旦消失した一次線毛が、腫瘍細胞で再度出現する現象が、膵癌に対する化学療法や放射線療法の効果判定の有効な指標になる可能性がある。
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