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Factors relating distribution and pathophysiology of eosinophilic gastrointestinal diseases

Research Project

Project/Area Number 18K07939
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionShimane University

Principal Investigator

Ishimura Norihisa  島根大学, 学術研究院医学・看護学系, 准教授 (40346383)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords好酸球性消化管疾患 / 好酸球性食道炎 / 好酸球性胃腸炎 / 性差
Outline of Final Research Achievements

Eosinophilic gastrointestinal diseases (EGID) are chronic Th2-type allergic diseases characterized by dense infiltration of eosinophils in the gastrointestinal tract and functional disorders originating from that location. EGID can be divided into eosinophilic esophagitis (EoE) and eosinophilic gastroenteritis (EGE) based on the involved gastrointestinal tract. However, male predominance in EoE remains to be elucidated. In this study, we evaluated the gene expression of EoE and EGE and showed that expression of CAPN14 related genes did not differ between male and female. While, gene expressions related to barrier function were changed after administration of dihydrotestosterone in squamous cell organoid culture system. In addition, we evaluated the microbiota in EoE and EGE using a 16S rRNA gene sequencing method. Bacterial composition was different between EoE and EGE, though no significant difference was seen between male and female in EGID.

Academic Significance and Societal Importance of the Research Achievements

近年、先進国を中心としてアレルギー疾患の増加が指摘されており、衛生環境の改善などの環境的要因が大きく影響していると考えられている。アレルギー疾患の中で明確な男女差があるのはEoEのみであるが、性差の原因は不明である。今回、男性ホルモンであるDHTが食道上皮のバリア機能に影響する可能性を初めて示した。この結果は、高齢者では発症の男女差がなくなる点とも一致している。また、EoEとEGEでは腸内細菌叢のパターンに違いが見られており、病変の分布との関連性を示唆する結果であった。今回の検討はEoEの病態形成機序や好酸球性炎症の罹患範囲に関わる要因を明らかにする上で意義のある結果と考えられる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (41 results)

All 2021 2020 2019 2018

All Journal Article (25 results) (of which Peer Reviewed: 17 results,  Open Access: 5 results) Presentation (16 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] Prevalence of Barrett&apos;s Epithelium Shown by Endoscopic Observations with Linked Color Imaging in Subjects with Different <i>H. pylori</i> Infection Statuses2021

    • Author(s)
      Adachi Kyoichi、Ishimura Norihisa、Kishi Kanako、Notsu Takumi、Mishiro Tomoko、Sota Kazunari、Ishihara Shunji
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 5 Pages: 667-674

    • DOI

      10.2169/internalmedicine.5676-20

    • NAID

      130007993482

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-03-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Similarity and difference in the characteristics of eosinophilic esophagitis between Western countries and Japan2021

    • Author(s)
      Ishimura Norihisa、Okimoto Eiko、Shibagaki Kotaro、Nagano Nahoko、Ishihara Shunji
    • Journal Title

      Digestive Endoscopy

      Volume: in press Issue: 5 Pages: 708-719

    • DOI

      10.1111/den.13786

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Characteristics and Treatment Outcomes of Patients with Eosinophilic Esophagitis and Eosinophilic Gastroenteritis2021

    • Author(s)
      Okimoto Eiko、Ishimura Norihisa、Ishihara Shunji
    • Journal Title

      Digestion

      Volume: 102 Issue: 1 Pages: 33-40

    • DOI

      10.1159/000511588

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] スギ花粉症に対する舌下免疫療法開始後に発症し、服薬法変更により改善した好酸球性食道炎の1例2021

    • Author(s)
      野津巧、足立経一、石村典久、岸加奈子、三代知子、曽田一也、沖本英子、川島耕作、石原俊治、木下芳一
    • Journal Title

      Gastroenterological Endoscopy

      Volume: 63 Pages: 183-187

    • NAID

      130007989739

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eosinophilic Granulomatosis with Polyangiitis Initially Diagnosed as Eosinophilic Gastroenteritis2020

    • Author(s)
      Itawaki Ayako、Okada Mayumi、Kawashima Kousaku、Okimoto Eiko、Sonoyama Hiroki、Mishima Yoshiyuki、Oshima Naoki、Ishimura Norihisa、Moriyama Mayuko、Murakawa Yohko、Araki Asuka、Ishikawa Noriyoshi、Maruyama Riruke、Ishihara Shunji、Kinoshita Yoshikazu
    • Journal Title

      Internal Medicine

      Volume: 59 Issue: 8 Pages: 1029-1033

    • DOI

      10.2169/internalmedicine.3391-19

    • NAID

      130007831687

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2020-04-15
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Is Malignant Potential of Barrett’s Esophagus Predictable by Endoscopy Findings?2020

    • Author(s)
      Amano Yuji、Ishimura Norihisa、Ishihara Shunji
    • Journal Title

      Life

      Volume: 10 Issue: 10 Pages: 244-244

    • DOI

      10.3390/life10100244

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical expression of filaggrin is decreased in proton pump inhibitor non-responders compared with proton pump inhibitor responders of eosinophilic esophagitis2020

    • Author(s)
      Nagano Nahoko、Araki Asuka、Ishikawa Noriyoshi、Nagase Mamiko、Adachi Kyoichi、Ishimura Norihisa、Ishihara Shunji、Kinoshita Yoshikazu、Maruyama Riruke
    • Journal Title

      Esophagus

      Volume: 18 Issue: 2 Pages: 362-371

    • DOI

      10.1007/s10388-020-00781-2

    • NAID

      40022522957

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPIと好酸球性食道炎2020

    • Author(s)
      石村典久、沖本英子、柴垣広太郎、石原俊治
    • Journal Title

      消化器内視鏡

      Volume: 32 Pages: 1132-1140

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 好酸球性胃腸炎2020

    • Author(s)
      石村典久、沖本英子、石原俊治
    • Journal Title

      IBD Research

      Volume: 14 Pages: 243-248

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 好酸球性胃腸炎における大腸病変2020

    • Author(s)
      石原俊治、石村典久、川島耕作
    • Journal Title

      消化器内視鏡

      Volume: 32 Pages: 198-199

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 炎症性疾患 アレルギー性腸炎2020

    • Author(s)
      沖本英子、三代剛、石村典久、石原俊治
    • Journal Title

      日本臨床

      Volume: 別冊消化管症候群Ⅲ Pages: 220-223

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 頸部食道inlet patch-咽喉頭部不快感, 球症状の隠れた原因?2020

    • Author(s)
      石村典久、柴垣広太郎
    • Journal Title

      消化器内科

      Volume: 2 Pages: 41-48

    • Related Report
      2019 Research-status Report
  • [Journal Article] Gastric foveolar-type adenomas endoscopically showing a raspberry-like appearance in the Helicobacter pylori-uninfected stomach2019

    • Author(s)
      Shibagaki Kotaro、Fukuyama Chika、Mikami Hironobu、Izumi Daisuke、Yamashita Noritsugu、Mishiro Tsuyoshi、Oshima Naoki、Ishimura Norihisa、Sato Shuichi、Ishihara Shunji、Nagase Mamiko、Araki Asuka、Ishikawa Noriyoshi、Maruyama Riruke、Kushima Ryoji、Kinoshita Yoshikazu
    • Journal Title

      Endoscopy International Open

      Volume: 07 Issue: 06 Pages: E784-E791

    • DOI

      10.1055/a-0854-3818

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fundic gland polyp prevalence according to Helicobacter pylori infection status2019

    • Author(s)
      Notsu Takumi、Adachi Kyoichi、Mishiro Tomoko、Ishimura Norihisa、Ishihara Shunji
    • Journal Title

      Journal of Gastroenterology and Hepatology

      Volume: in press Issue: 7 Pages: 1158-1162

    • DOI

      10.1111/jgh.14934

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] 胃食道逆流症の疫学と病因・病態2019

    • Author(s)
      石村典久
    • Journal Title

      日本臨床

      Volume: 77 Pages: 1593-1600

    • Related Report
      2019 Research-status Report
  • [Journal Article] 原因が特定できない腹痛・下痢患者への対応2019

    • Author(s)
      石村典久、沖本英子
    • Journal Title

      内科

      Volume: 123 Pages: 555-556

    • Related Report
      2019 Research-status Report
  • [Journal Article] Is Asymptomatic Esophageal Eosinophilia the Same Disease Entity as Eosinophilic Esophagitis?2018

    • Author(s)
      Ishimura Norihisa、Sumi Shohei、Okada Mayumi、Mikami Hironobu、Okimoto Eiko、Nagano Nahoko、Araki Asuka、Tamagawa Yuji、Mishiro Tsuyoshi、Oshima Naoki、Ishihara Shunji、Maruyama Riruke、Kinoshita Yoshikazu
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: - Issue: 7 Pages: 1405-1407

    • DOI

      10.1016/j.cgh.2018.08.048

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Advantages and disadvantages of long-term proton pump inhibitor use2018

    • Author(s)
      Kinoshita Y, Ishimura N, Ishihara S
    • Journal Title

      J Neurogastroenterol Motil

      Volume: 24 Issue: 2 Pages: 182-196

    • DOI

      10.5056/jnm18001

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Eosinophilic esophagitis in Japan: Focus on response to acid suppressive therapy2018

    • Author(s)
      Ishimura N, Kinoshita Y
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 33 Issue: 5 Pages: 1016-1022

    • DOI

      10.1111/jgh.14079

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Management of GERD: Are Potassium-Competitive Acid Blockers Superior to Proton Pump Inhibitors?2018

    • Author(s)
      Kinoshita Y, Ishimura N, Ishihara S
    • Journal Title

      Am J Gastroenterol

      Volume: 113 Issue: 10 Pages: 1417-1419

    • DOI

      10.1038/s41395-018-0183-8

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Oral microbiome alterations of healthy volunteers with proton pump inhibitor2018

    • Author(s)
      Mishiro Tsuyoshi、Oka Kentaro、Kuroki Yasutoshi、Takahashi Motomichi、Tatsumi Kasumi、Saitoh Tsukasa、Tobita Hiroshi、Ishimura Norihisa、Sato Shuichi、Ishihara Shunji、Sekine Joji、Wada Koichiro、Kinoshita Yoshikazu
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 33 Issue: 5 Pages: 1059-1066

    • DOI

      10.1111/jgh.14040

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of eosinophilic esophagitis following sublingual immunotherapy with cedar pollen extract: A case report2018

    • Author(s)
      Kawashima K, Ishihara S, Masuhara M, Mikami H, Okimoto E, Oshima N, Ishimura N, Araki A, Maruyama R, Kinoshita Y
    • Journal Title

      Allergology International

      Volume: 67 Issue: 4 Pages: 515-517

    • DOI

      10.1016/j.alit.2018.03.003

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful Food-Elimination Diet in an Adult with Eosinophilic Gastroenteritis2018

    • Author(s)
      Okimoto E, Ishimura N, Okada M, Mikami H, Sonoyama H, Ishikawa N, Araki A, Oshima N, Hirai J, Ishihara S, Maruyama R, Kinoshita Y
    • Journal Title

      ACG Case Rep J

      Volume: 5 Issue: 1 Pages: e38-e38

    • DOI

      10.14309/crj.2018.38

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 好酸球と消化管疾患2018

    • Author(s)
      石原俊治、沖本英子、大嶋直樹、石村典久、木下芳一
    • Journal Title

      消化器病サイエンス

      Volume: 2 Pages: 198-202

    • Related Report
      2018 Research-status Report
  • [Journal Article] Recent progress in the research of Eosinophilic GastroIntestinal Diseases (EGIDs)2018

    • Author(s)
      三代剛、石村典久、石原俊治、木下芳一
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 152 Issue: 4 Pages: 175-180

    • DOI

      10.1254/fpj.152.175

    • NAID

      130007495945

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 好酸球性食道炎の治療後経過に関する検討2021

    • Author(s)
      石村典久、沖本英子、三代剛、大嶋直樹、川島耕作、石原俊治
    • Organizer
      第17回日本消化管学会総会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Risk of neoplastic progression in patients with long-segment Barrett's esophagus- Japan multicenter prospective cohort study2020

    • Author(s)
      Ishimura Norihisa、Matsuhahi Nobuyuki、Fujisaki Junko、Endo Takao、Koike Tomoyuki、Dobashi Akira、Kawada Kenro、Ishihara Ryu、Matsueda Kazuhiro、Mukaisho Ken-Ichi、Furuta Takahisa、Kinoshita Yoshikazu、Haruma Ken、Iishi Hiroyasu、Iijima Katsunori
    • Organizer
      Digestive Disease Week 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 好酸球性食道炎と好酸球性胃腸炎の病態の相違と治療の現状2020

    • Author(s)
      沖本英子, 石村典久, 石原俊治
    • Organizer
      第16回日本消化管学会総会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 縦軸8ch pHモニタリングシステムを用いた胃acid pocketの評価および酸分泌抑制薬のacid pocketに対する効果に関する検討2020

    • Author(s)
      角昇平, 石村典久, 石原俊治, 木下芳一
    • Organizer
      第16回日本消化管学会総会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 健常ボランティアにおけるプロトンポンプ阻害薬内服時の常在細菌叢変化に関する検討2020

    • Author(s)
      三代剛, 黒木靖敏, 岡健太郎, 高橋志達, 飛田博史, 石村典久, 木下芳一, 石原俊治
    • Organizer
      第16回日本消化管学会総会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 好酸球性食道炎の治療経過における内視鏡像の評価2019

    • Author(s)
      石村典久, 岡田真由美, 沖本英子
    • Organizer
      第97回日本消化器内視鏡学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] microRNAの網羅的解析を用いた好酸球性食道炎のバイオマーカーの探索2019

    • Author(s)
      大嶋直樹, 石村典久, 石原俊治
    • Organizer
      第97回日本消化器内視鏡学会総会
    • Related Report
      2019 Research-status Report
  • [Presentation] 好酸球性消化管疾患の臨床的特徴と多種食物除去療法の治療効果2019

    • Author(s)
      石村典久, 沖本英子, 石原俊治, 木下芳一
    • Organizer
      第68回日本アレルギー学会学術大会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Application of convolutional neural networks for diagnosis of eosinophilic esophagitis based on endoscopic images2019

    • Author(s)
      Okimoto E, Ishimura N, Aoyama K, Tada T, Adachi K, Kinoshita Y
    • Organizer
      UEG Week 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 人工知能を用いた好酸球性食道炎の内視鏡診断2019

    • Author(s)
      沖本英子, 石村典久, 多田智裕, 木下芳一
    • Organizer
      JDDW 2019
    • Related Report
      2019 Research-status Report
  • [Presentation] 症例対照研究による好酸球性食道炎のリスク因子に関する検討2019

    • Author(s)
      石村典久, 沖本英子, 足立経一
    • Organizer
      JDDW 2019
    • Related Report
      2019 Research-status Report
  • [Presentation] 好酸球性胃腸炎に対する多種食物除去療法に関する検討2019

    • Author(s)
      沖本英子、石村典久、岡田真由美、三上博信、玉川祐司、大嶋直樹、石原俊治、木下芳一
    • Organizer
      第15回日本消化管学会総会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 好酸球性胃腸炎に対する腸溶性ブデソニドの使用経験2019

    • Author(s)
      大嶋直樹、石村典久、角昇平、岡田真由美、沖本英子、玉川祐司、三島義之、川島耕作、石原俊治、木下芳一
    • Organizer
      第15回日本消化管学会総会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 好酸球性食道炎のPPI無効例に対するボノプラザンの効果に関する検討2018

    • Author(s)
      沖本英子、石村典久、角昇平、岡田真由美、三上博信、玉川祐司、三代剛、大嶋直樹、石原俊治、木下芳一
    • Organizer
      第72回日本食道学会集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 好酸球性食道炎患者における食道運動機能と食道壁伸展性についての検討2018

    • Author(s)
      三上博信、石村典久、角昇平、岡田真由美、沖本英子、大嶋直樹、石原俊治、木下芳一
    • Organizer
      第72回日本食道学会集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 好酸球性消化管疾患に対する食事療法2018

    • Author(s)
      沖本英子、石村典久、岡田真由美、大嶋直樹、木下芳一
    • Organizer
      第110回日本消化器病学会中国支部例会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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