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Autoantibodies in patients with autoimmune pancreatitis: its pathophysiological roles and clinical significance

Research Project

Project/Area Number 18K07958
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research Institution株式会社関西メディカルネット(関西電力医学研究所)

Principal Investigator

Chiba Tsutomu  株式会社関西メディカルネット(関西電力医学研究所), 関西電力医学研究所, 学術顧問 (30188487)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords自己免疫性膵炎 / 抗ラミニン511抗体 / 自己抗体 / IgG4関連疾患 / ラミニン抗体 / IgG4硬化性胆管炎 / ラミニン511-E8抗体 / ラミニン511抗体 / IgG4
Outline of Final Research Achievements

We examined significance of anti-laminin 511 antibody in patients with autoimmune pancreatitis (AIP). In AIP patients with anti-laminin antibody, pancreas damage was more broad as compared to those without the antibody, and association of cancer and allergy was less prominent than in those without the antibody. A number of AIP patients without anti-laminin antibody had anti-integrin α6β1 antibody, and these were frequently associated with cancer or allergy. Nearly half of AIP patients had IgG4-related cholangitis, a half of which were positive for anti-laminin antibody. Some patients with type II AIP had anti-laminin antibody, and these patients were considered type I AIP. In contrast, some AIP patients with positive for neither antibody had UC. These patients were considered type II AIP.
Administration of IgG from AIP patients induced not only pancreatic but also biliary lesion in neonatal mice, but no pathology was found in lacrimal gland, salivary gland and in the kidney.

Academic Significance and Societal Importance of the Research Achievements

抗ラミニン511抗体を測定することによって、AIPの診断のみならず、原発性硬化性胆管炎とIgG4関連胆管炎を鑑別が可能となる。またI型、II型AIPの鑑別も容易になり、治療法の選択に役立つと思われた。一方、患者の抗体投与により病変が形成されることは、AIPの発症に自己抗体が関与することを示しており、このことは、今後の治療法開発に役立つと期待される。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2021 2020 2019 2018

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results)

  • [Journal Article] Epithelial expression of Gata4 and Sox2 regulates specification of the squamous?columnar junction via MAPK/ERK signaling in mice2021

    • Author(s)
      Sankoda Nao、Tanabe Wataru、Tanaka Akito、Shibata Hirofumi、Woltjen Knut、Chiba Tsutomu、Haga Hironori、Sakai Yoshiharu、Mandai Masaki、Yamamoto Takuya、Yamada Yasuhiro、Uemoto Shinji、Kawaguchi Yoshiya
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1-15

    • DOI

      10.1038/s41467-021-20906-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different frequencies of antibody responses in IgG4-related disease2020

    • Author(s)
      Shiokawa M, Kodama Y, Chiba T
    • Journal Title

      Arthritis Rheumatology

      Volume: 72 Issue: 9 Pages: 1484-1485

    • DOI

      10.1002/art.41393

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Phenotyping of IgG4-related diseases based on affected organ pattern: A multicenter cohort study using cluster analysis.2020

    • Author(s)
      Niwamoto T, Handa T, Matsui S, Yamamoto H, Yoshifuji H, Abe H, MatsumotoH, Kodama Y, Chiba T, Seno H, Mimori T, Hirai T.
    • Journal Title

      Modern Rheumatology

      Volume: in press Issue: 1 Pages: 235-240

    • DOI

      10.1080/14397595.2019.1703522

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intra-epithelial lymphocytes in the intestine2019

    • Author(s)
      Zhu Yuanbo、Cui Guangwei、Miyauchi Eiji、Nakanishi Yuki、Mukohira Hisa、Shimba Akihiro、Abe Shinya、Tani-ichi Shizue、Hara Takahiro、Nakase Hiroshi、Chiba Tsutomu、Sehara-Fujisawa Atsuko、Seno Hiroshi、Ohno Hiroshi、Ikuta Koichi
    • Journal Title

      International Immunology

      Volume: 32 Issue: 5 Pages: 307-319

    • DOI

      10.1093/intimm/dxz082

    • NAID

      120006846480

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Case of IgG4-associated sclerosing cholangitis with normal serum IgG4 concentration, diagnosed by anti-laminin 511-E8 antibody: a novel autoantibody in patients with autoimmune pancreatitis2019

    • Author(s)
      Kato Y, Chiba T, et al.
    • Journal Title

      Gut

      Volume: 68 Issue: 3 Pages: 1-3

    • DOI

      10.1136/gutjnl-2018-317934

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Laminin 511 is a target antigen in autoimmune pancreatitis2018

    • Author(s)
      Shiokawa M, Chiba T, et al.
    • Journal Title

      Sci Transl Med

      Volume: 10 Issue: 453 Pages: 1-10

    • DOI

      10.1126/scitranslmed.aaq0997

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2018-04-23   Modified: 2022-01-27  

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