Noninvasive diagnostic imaging for liver fibrosis and fatty liver with hepatocellular carcinoma risk prediction based on ultrasonic medicine and morphology
Project/Area Number |
18K07985
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53010:Gastroenterology-related
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Research Institution | Hyogo Medical University |
Principal Investigator |
Iijima Hiroko 兵庫医科大学, 医学部, 教授 (80289066)
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Co-Investigator(Kenkyū-buntansha) |
藤元 治朗 兵庫医科大学, 医学部, 特別招聘教授 (90199373)
矢野 博久 久留米大学, 医学部, 教授 (40220206)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | 線維化 / 肝脂肪化 / 超音波 / 脂肪減衰法 / Elastography / 肝発癌リスク |
Outline of Final Research Achievements |
Liver stiffness (LS) by shear wave elastography was obtained with 809 patients. The result was compared with histology of fibrosis. The AUROC of transient elastography to predict F2<, F3<, and F4 was 0.809, 0.860 and 0.947; that of virtual touch quantification was 0.793, 0.836 and 0.941, respectively. LS showed significant increase with the progression of fibrosis. Diagnosis of liver fibrosis based on LS measurement was established to avoid invasive diagnosis. Attenuation imaging (ATI) enables to quantitively assess liver steatosis as accurate as controlled attenuation parameter. In 119 steatosis cases, the correlation of ATI with MRI-derived proton density fat fraction (PDFF) was r=0.70. ATI showed a good diagnostic ability as MRI-PDFF. Post-sustained virologic response HCC occurrence is observed more in patients with higher LS and glucose level. A electronic microscopic study showed a higher rate of mitochondrial disorder in HCC recurrence cases.
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Academic Significance and Societal Importance of the Research Achievements |
超音波エラストグラフィは、機種間の差が無く肝線維化診断ができる方法として確立された。異なる方法でも換算式で比較出来る方法を考案した。ゴールドスタンダードである肝生検は入院が必須で出血等の合併症がある。肝臓全体の1/50,000の組織しか採取できずサンプリングエラーが30%前後と報告され、病理医間の読影差もある。エラストグラフィは肝生検に替わる方法として医療に貢献できる。さらに測定値は、線維化と脂肪減衰量を連続変数で定量評価できる。脂肪肝の有病率が上昇し肝線維化脂肪化診断は今後さらに社会的需要が高まる。発癌リスク危険群が同定できたことは極めて大きい。
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Report
(4 results)
Research Products
(38 results)
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[Journal Article] Usefulness of Attenuation Imaging with an Ultrasound Scanner for the Evaluation of Hepatic Steatosis.2019
Author(s)
Tada T, Iijima H, Kobayashi N, Yoshida M, Nishimura T, Kumada T, Kondo R, Yano H, Kage M, Nakano C, Aoki T, Aizawa N, Ikeda N, Takashima T, Yuri Y, Ishii N, Hasegawa K, Takata R, Yoh K, Sakai Y, Nishikawa H, Iwata Y, Enomoto H, Hirota S, Fujimoto J, Nishiguchi S.
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Journal Title
Ultrasound Med Biol.
Volume: 45(10)
Issue: 10
Pages: 2679-2687
DOI
Related Report
Peer Reviewed
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[Journal Article] Elevated levels of circulating ITIH4 are associated with hepatocellular carcinoma with nonalcoholic fatty liver disease: from pig model to human study.2019
Author(s)
Nakamura N, Hatano E, Iguchi K, Sato M, Kawaguchi H, Ohtsu I, Sakurai T, Aizawa N, Iijima H, Nishiguchi S, Tomono T, Okuda Y, Wada S, Seo S, Taura K, Uemoto S, Ikegawa M.
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Journal Title
BMC Cancer.
Volume: 19(1)
Issue: 1
Pages: 621-621
DOI
Related Report
Peer Reviewed
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[Journal Article] Comparison of liver stiffness assessment by transient elastography and shear wave elastography using six ultrasound devices.2019
Author(s)
Iijima H, Tada T, Kumada T, Kobayashi N, Yoshida M, Aoki T, Nishimura T, Nakano C, Ishii A, Takashima T, Sakai Y, Aizawa N, Nishikawa H, Ikeda N, Iwata Y, Enomoto H, Ide YH, Hirota S, Fujimoto J, Nishiguchi S.
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Journal Title
Hepatol Res.
Volume: 49(6)
Issue: 6
Pages: 676-686
DOI
Related Report
Peer Reviewed
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[Journal Article] Liver Fibrosis Markers as Assessed by Ultrasound Elastography and Serum Samples: A Large Comparative Study in Hepatitis Virus B and C Liver Diseases2019
Author(s)
Nishimura T, Iijima H, Nishikawa H, Kondo R, Yano H, Kage M, Aoki T, Nakano C, Yuri Y, Ishii N, Hasegawa K, Takata R, Yoh K, Sakai Y, Takashima T, Aizawa N, Ikeda N, Iwata Y, Enomoto H, Hirota S, Fujimoto J, Nishiguchi S.
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Journal Title
Hepatol Res .
Volume: 49(7)
Issue: 7
Pages: 721-730
DOI
Related Report
Peer Reviewed
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[Journal Article] Changes in liver stiffness and steatosis among patients with hepatitis C virus infection who received direct-acting antiviral therapy and achieved sustained virological response.2018
Author(s)
Kobayashi N, Iijima H, Tada T, Kumada T, Yoshida M, Aoki T, Nishimura T, Nakano C, Takata R, Yoh K, Ishii A, Takashima T, Sakai Y, Aizawa N, Nishikawa H, Ikeda N, Iwata Y, Enomoto H, Hirota S, Fujimoto J, Nishiguchi S.
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Journal Title
Eur J Gastroenterol Hepatol.
Volume: 30(5)
Issue: 5
Pages: 546-551
DOI
Related Report
Peer Reviewed
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[Journal Article] Pathological findings that contribute to tissue stiffness in the spleen of liver cirrhosis patients.2018
Author(s)
Kondo R, Kage M, Iijima H, Fujimoto J, Nishimura T, Aizawa N, Akiba J, Naito Y, Kusano H, Nakayama M, Mihara Y, Tanigawa M, Yano H.
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Journal Title
Hepatol Res.
Volume: 48(12)
Issue: 12
Pages: 1000-1007
DOI
Related Report
Peer Reviewed
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[Journal Article] A new method to evaluate hepatic steatosis using ultrasound "Attenuation imaging"2018
Author(s)
飯島 尋子, 西村 貴士, 多田 俊史, 中野 智景, 青木 智子, 高嶋 智之, 池田直人, 會澤 信弘, 西川 浩樹, 岩田 恵典, 榎本 平之, 藤元 治朗, 鹿毛 政義, 熊田 卓, 西口 修平, 矢野 博久.
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Journal Title
Kanzo
Volume: 59
Issue: 1
Pages: 65-67
DOI
NAID
ISSN
0451-4203, 1881-3593
Related Report
Peer Reviewed
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[Presentation] Clinically Significant Portal Hypertension C型肝硬変に対するDAA治療による肝硬度変化の意義2020
Author(s)
西村 貴士, 會澤 信弘, 長谷川 国大, 高田 亮, 楊 和典, 坂井 良行, 高嶋 智之, 池田 直人, 西川 浩樹, 岩田 恵典, 榎本 平之, 飯島 尋子
Organizer
第27回日本門脈圧亢進症学会総会
Related Report
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[Presentation] NAFLD/NASH診断における総合超音波画像診断の有用性2019
Author(s)
西村 貴士, 青木 智子, 中野 智景, 楊 和典, 近藤 礼一郎, 高嶋 智之, 坂井良行,井出 良浩, 會澤 信弘, 池田 直人, 西川 浩樹, 岩田 恵典, 榎本 平之, 波多野 悦朗, 廣田 誠一, 藤元 治朗, 鹿毛 政義, 西口 修平, 飯島 尋子
Organizer
第105回日本消化器病学会総会
Related Report
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[Presentation] Usefulness of Superb Micro Vascular Imaging in the Diagnosis of Focal NodularHyperplasia.2018
Author(s)
Takashi Nishimura1, Mariko Hashimoto, Chikage Nakano, Nobuhiro Aizawa, Naoto Ikeda, TomoyukiTakashima, Hiroki Nishikawa, Yoshinori Iwata, Hirayuki Enomoto, Jiro Fujimoto, Shuhei Nishiguchi Hiroko Iijima.
Organizer
The 69rd Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2018)
Related Report
Int'l Joint Research
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[Presentation] Study on the Influence of Fatty Liver Disease in Chronic Type B Liver Disease.2018
Author(s)
Nobuhiro Aizawa, Hirayuki Enomoto, Noriko Ishii, Chikage Nakano, Yukihisa Yuri, Ryo Takata, Kazunori Yoh, Tomoyuki Takashima, Yoshiyuki Sakai, Naoto Ikeda, Yoshinori Iwata, Takashi Nishimura, Hiroki Nishikawa, Hiroko Iijima, Shuhei Nishiguchi.
Organizer
The 69rd Annual Meeting of the American Association for the Study of Liver Diseases(AASLD2018)
Related Report
Int'l Joint Research
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[Presentation] 肝硬変の成因別実態 当科における肝硬変の成因別実態.2018
Author(s)
高嶋 智之, 榎本 平之, 井上 美奈子, 宮本 優帆, 石井 紀子, 中野 智景, 長谷川 国大, 由利 幸久, 高田 亮, 楊 和典, 石井 昭生, 坂井 良行, 西村 貴士, 會澤 信弘, 西川 浩樹, 池田 直人, 岩田 恵典, 飯島 尋子, 西口 修平.
Organizer
第54回日本肝臓学会総会
Related Report
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[Presentation] 脂肪肝診療におけるAttenuation Imagingの有用性―病理組織所見との対比―.2018
Author(s)
小林 奈津子, 飯島 尋子, 多田 俊史, 中野 智景, 青木 智子, 西村 貴士, 高嶋 智之, 會澤 信弘, 池田 直人, 榎本 平之, 矢野 博久, 鹿毛 政義, 熊田 卓, 西口 修平.
Organizer
第54回日本肝臓学会総会
Related Report
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[Presentation] C型肝炎の抗ウイルス治療前後における、生化学データ・線維化マーカー・食道胃静脈瘤形態の比較.2018
Author(s)
由利 幸久, 西川 浩樹, 井上 美奈子, 宮本 優帆, 中野 智景, 石井 紀子, 長谷川 国大, 高田 亮, 楊 和典, 石井 昭生, 高嶋 智之, 坂井 良行, 會澤 信弘, 池田 直人, 西村 貴士, 岩田 恵典, 榎本 平之, 飯島 尋子, 西口 修平.
Organizer
第54回日本肝臓学会総会
Related Report
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