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Alterations of gut microbiome and mucosal permeability in inactive IBD patients with IBS-like symptom

Research Project

Project/Area Number 18K07986
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionHyogo Medical University

Principal Investigator

TOMITA TOSHIHIKO  兵庫医科大学, 医学部, 准教授 (60388824)

Co-Investigator(Kenkyū-buntansha) 福井 広一  兵庫医科大学, 医学部, 准教授 (60378742)
三輪 洋人  兵庫医科大学, 医学部, 教授 (80190833)
Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords炎症性腸疾患 / 過敏性腸症候群 / 微小炎症持続 / 腸内細菌叢 / 消化器症状 / メカニズム
Outline of Final Research Achievements

Although irritable bowel syndrome (IBS)-like symptoms are frequently occurred in patients with quiescent Crohn’s disease (CD), its pathophysiology is remained unclear. To approach the responsible factors for IBS-like symptoms in quiescent CD patients, we performed comprehensive analyses of clinical features and intestinal environment in those patients. we have investigated clinical data sets and intestinal environmental factors in quiescent CD patients with IBS-like symptom. Among many factors examined, we found that intestinal minimal inflammation and anxiety are closely associated with the development of IBS-like symptom in quiescent CD patients. In addition, reduction of Fusicatenibacter strains may be involved in the intestinal minimal inflammation in quiescent CD patients with IBS-like symptom. This suggests that the corrective effect on gut microbiota profile by probiotics may be possible target for the treatment of quiescent CD patients with IBS-like symptom.

Academic Significance and Societal Importance of the Research Achievements

本研究研究結果から、今後、実地臨床でプロバイオティクス投与による腸内細菌叢プロファイルの改善が、IBS様症状を有する寛解期クローン病患者の治療ターゲットになる可能性があることを示唆している。この問題を明らかにするために、現在、臨床試験を開始している。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (9 results)

All 2021 2020 2019 2018

All Journal Article (7 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 7 results,  Open Access: 3 results) Presentation (2 results)

  • [Journal Article] Senna Versus Magnesium Oxide for the Treatment of Chronic Constipation: A Randomized, Placebo-Controlled Trial.2021

    • Author(s)
      Morishita D, Tomita T, Mori S, Kimura T, Oshima T, Fukui H, Miwa H.
    • Journal Title

      Am J Gastroenterol.

      Volume: 116 Issue: 1 Pages: 152-161

    • DOI

      10.14309/ajg.0000000000000942

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decreased Colonic Guanylin/Uroguanylin Expression and Dried Stool Property in Mice With Social Defeat Stress.2020

    • Author(s)
      Ebisutani N, Fukui H, Nishimura H, Nakanishi T, Morimoto K, Itou S, Nakamura A, Masutani M, Hori M, Tomita T, Oshima T, Kasahara E, Sekiyama A, Miwa H.
    • Journal Title

      Front Physiol.

      Volume: 14 Pages: 599582-599582

    • DOI

      10.3389/fphys.2020.599582

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of chronic constipation on health-related quality of life and work productivity in Japan.2020

    • Author(s)
      Tomita T, Kazumori K, Baba K, Zhao X, Chen Y, Miwa H.
    • Journal Title

      J Gastroenterol Hepatol.

      Volume: 13 Issue: 6 Pages: 15295-15295

    • DOI

      10.1111/jgh.15295

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Alteration of Colonic Mucosal Permeability during Antibiotic-Induced Dysbiosis.2020

    • Author(s)
      Ran Y, Fukui H, Xu X, Wang X, Ebisutani N, Tanaka Y, Maeda A, Makizaki Y, Ohno H, Kondo T, Kono T, Tozawa K, Tomita T, Oshima T, Miwa H.
    • Journal Title

      Int J Mol Sci.

      Volume: 21 Issue: 17 Pages: 6108-6108

    • DOI

      10.3390/ijms21176108

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Link Between Type III Reg and STAT3-Associated Cytokines in Inflamed Colonic Tissues2019

    • Author(s)
      Xin Xu , Hirokazu Fukui , Ying Ran , Xuan Wang , Yoshihito Inoue , Nobuhiko Ebisudani, Heihachiro Nishimura, Toshihiko Tomita , Tadayuki Oshima , Jiro Watari , Hiroshi Kiyama , Hiroto Miwa
    • Journal Title

      Mediators Inflamm

      Volume: 6 Pages: 7859460-7859460

    • DOI

      10.1155/2019/7859460

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Alteration of GLP-1/GPR43 expression and gastrointestinal motility in dysbiotic mice treated with vancomycin.2019

    • Author(s)
      Xu X, Fukui H, Ran Y, Tomita T, Oshima T, Watari J, Miwa H.
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 4381-4381

    • DOI

      10.1038/s41598-019-40978-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association between gastrointestinal motility and macrophage/mast cell distribution in mice during the healing stage after DSS-induced colitis2018

    • Author(s)
      Kodani M, Fukui H, Tomita T, Oshima T, Watari J, Miwa H.
    • Journal Title

      Mol Med Rep

      Volume: 17 Pages: 8167-8172

    • DOI

      10.3892/mmr.2018.8926

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 慢性便秘患者に対する浸透圧性下剤の有用性(プラセボ対照二重盲検比較試験)2020

    • Author(s)
      富田寿彦、森 すみれ、三輪洋人
    • Organizer
      JDDW2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 慢性便秘症の健康関連QOLや労働生産性に与える影響-傾向スコア解析による検討-2020

    • Author(s)
      富田寿彦,馬場健次,数森清康,大島忠之,福井広一,三輪洋人.
    • Organizer
      第21回日本神経消化器病学会・第47回日本潰瘍学会
    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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