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Chemoprevention of pancreatic cancer by metformin

Research Project

Project/Area Number 18K08011
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionYokohama City University

Principal Investigator

HOSONO Kunihiro  横浜市立大学, 附属病院, 講師 (50537339)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords膵癌 / 化学予防 / メトホルミン
Outline of Final Research Achievements

Although the number of pancreatic cancer cases has been increasing in recent years due to the aging of the population and changes in dietary habits, early diagnosis of pancreatic cancer is difficult and the establishment of effective preventive methods is required in the future. In this study, the chemopreventive effect of metformin in pancreatic cancer was examined by organoid analysis, animal experiments using mouse models of pancreatic carcinogenesis, and clinical pilot studies in pancreatic cancer patients. The aim is to elucidate the mechanism of action of metformin by conducting gene expression analysis and protein analysis, and to realize chemoprevention of pancreatic cancer by metformin.

Academic Significance and Societal Importance of the Research Achievements

本研究の目的は、膵がんの新たな化学予防薬の実現化を目指すことにある。過去の膵がん化学予防の研究ではCOX-2選択的阻害剤などを用いて検討が行われていたが、重篤な心疾患などの副作用があり、他の安全な薬剤での検討が求められている。本研究で用いるメトホルミンについてはすでに50年以上にわたり抗糖尿病薬として臨床応用されており、コンプライアンスも高く、安価であり、副作用なども少なく、臨床応用へのハードルは低いといえる。そして得られた結果は膵がんハイリスク群への応用が可能であり、糖尿病治療薬として臨床的必要性の高い薬剤による難治性膵がん予防の実現化という点において本研究の臨床的意義は大きい。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (5 results)

All 2021 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (3 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Pathological Findings of the Host Immune Reaction in the Tumor Microenvironment of Gastroenteropancreatic Neuroendocrine Neoplasms2021

    • Author(s)
      Hasegawa Sho、Kobayashi Noritoshi、Okubo Naoki、Tokuhisa Motohiko、Goto Ayumu、Kurita Yusuke、Sato Takamitsu、Hosono Kunihiro、Endo Itaru、Nakajima Atsushi、Ichikawa Yasushi
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 7 Pages: 977-983

    • DOI

      10.2169/internalmedicine.5648-20

    • NAID

      130008014370

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-04-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The placement of multiple plastic stents still has important roles in candidates for chemotherapy for unresectable perihilar cholangiocarcinoma2020

    • Author(s)
      Iwasaki Akito、Kubota Kensuke、Kurita Yusuke、Hasegawa Sho、Fujita Yuji、Kagawa Koji、Kato Shingo、Sekino Yusuke、Hosono Kunihiro、Nakajima Atsushi
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 27 Issue: 10 Pages: 700-711

    • DOI

      10.1002/jhbp.804

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Presentation] サルコペニアからみた高齢者のERCP関連偶発症の検討2020

    • Author(s)
      細野 邦広 佐藤 高光 中島 淳
    • Organizer
      JDDW 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] New diagnostic approach for biliary tract cancer using organoid culture2019

    • Author(s)
      Kunihiro Hosono, Tetsuya matuura, Atsushi Nakajima
    • Organizer
      DDW 2019
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] 胆汁オルガノイドを用いた胆道癌診療の新たな展開2019

    • Author(s)
      細野邦広 松浦哲也 中島淳
    • Organizer
      第105回 日本消化器病学会総会
    • Related Report
      2019 Research-status Report

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Published: 2018-04-23   Modified: 2022-01-27  

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