| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The underlying mechanism between micro-inflammation and FD remains unknown. In this study, using a maternal separation (MS)-induced FD model, we aimed to reproduce the gastroduodenal micro-inflammation and reveal the interaction of gastroduodenal micro-inflammation and gastric hypersensitivity. MS model was established by separating newborn Sprague Dawley rats for 2 h a day from postnatal day 1 to 10. At 7-8 weeks of age, electromyography was used to determine the visceromotor response to gastric distention (GD). MS-induced FD rats underwent gastric hypersensitivity with GD. Eosinophils were significantly increased in the gastroduodenal tract. Treatment with dexamethasone reversed gastric hypersensitivity in MS-induced FD rats by inhibiting eosinophil infiltration. Our results indicate that neonatal MS stress induces eosinophil-associated gastroduodenal micro-inflammation and gastric hypersensitivity at adulthood in rats. Micro-inflammation contributes to gastric hypersensitivity.
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