| Project/Area Number |
18K08024
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | National Cardiovascular Center Research Institute (2020-2023)
Tohoku University (2018-2019) |
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Principal Investigator |
YASUHIKO SAKATA 国立研究開発法人国立循環器病研究センター, 病院, 部長 (90379206)
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| Co-Investigator(Kenkyū-buntansha) |
後岡 広太郎 東北大学, 大学病院, 特任准教授 (20598411)
宮田 敏 東北大学, 医学系研究科, 大学院非常勤講師 (60360343)
澤田 正二郎 東北大学, 大学病院, 講師 (60509420)
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| Project Period (FY) |
2018-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Heart Failure / Diabetes / Omics analysis / Diabetic Cardiomyopathy / 循環器内科学 / 心不全 / 脂肪酸 / 虚血性心疾患 / 糖尿病 / オミックス解析 / 糖尿病性心筋症 / バイオマーカー / マイクロRNA / メタボローム解析 |
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| Outline of Final Research Achievements |
Diabetic cardiomyopathy is a myocardial disorder that originates from metabolic abnormalities caused by diabetes. However, the mechanism of diabetic cardiomyopathy is unclear, and it is still difficult to approach the prevention and treatment of ischemic heart failure from the perspective of diabetes and metabolism. In this study, we performed omics analysis on cases of ischemic heart disease complicated with diabetes, and attempted to elucidate the pathogenesis mechanism of diabetic cardiomyopathy in ischemic heart disease. Fatty acids are the main components of biological lipids, and are involved in maintaining life, such as energy production and the formation of cell membranes. In this study, we demonstrated the possibility of free fatty acids as a prognostic predictor for the onset of cardiovascular events, including heart failure.
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| Academic Significance and Societal Importance of the Research Achievements |
糖尿病性心筋障害は糖尿病による代謝異常により生じる心筋障害です。しかしながらこれまでその発生機序は明らかではありませんでした。そこで本研究では糖尿病を合併する虚血性心疾患症例においてオミックス解析を行い、虚血性心疾患における糖尿病性心筋障害の病態形成機序の解明を試みました。
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