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Local hyperthermia treatment for peripheral arterial disease by using gold nano-rods

Research Project

Project/Area Number 18K08041
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionKyushu University

Principal Investigator

TOKUNOU Tomotake  九州大学, 大学病院, 講師 (50567378)

Co-Investigator(Kenkyū-buntansha) 樋口 義洋  九州大学, 大学病院, 講師 (40404032)
堀内 孝彦  九州大学, 大学病院, 教授 (90219212)
Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords低酸素 / 血管新生 / 金ナノロッド / 炎症 / 下肢虚血 / 温熱療法 / 腹部動脈瘤
Outline of Final Research Achievements

Gold nano-rods, rod-shaped gold nanoparticles, act as thermal converters for photothermal therapy. Intravenous gold nano-rods were accumulated in the reticuloendothelial system, such as liver and spleen. And the nano-rods were accumulated in the inflammatory site of heart failure model mice. In the lower limb ischemia model, unilateral femoral artery was ligated and resected, gold nano-rods were injected into the ischemic area. Local hyperthermia treatment (42 degree) was performed by using gold nano-rods and near-infrared laser. After 1 week therapy with this condition, gold nano-rods showed early improvement of ischemia, but further investigation is needed.

Academic Significance and Societal Importance of the Research Achievements

金ナノ粒子のフォトサーマル効果を利用して研究をおこなった。静注した金ナノ粒子は炎症部位に集積することが分かったが、下肢虚血モデルのように血流が少ない疾患では金ナノ粒子の注入方法を考える必要があった。また今回使用した棒状の金ナノ粒子(金ナノロッド)は、組織透過性の高い近赤外線領域に強い吸収域をもち、光エネルギーを熱に変換するフォトサーマル効果を利用することができた。心不全や下肢虚血には温熱療法の効果も示唆されているが、今回のように局所で温熱療法を行う手段としては選択肢の一つになりうると考える。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (8 results)

All 2022 2020 2019

All Journal Article (6 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Hot spring bathing is associated with a lower prevalence of hypertension among Japanese older adults: a cross-sectional study in Beppu.2022

    • Author(s)
      Yamasaki S, Tokunou T, Maeda T, Horiuchi T.
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 19462-19462

    • DOI

      10.1038/s41598-022-24062-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Recent advances in the management of secondary hypertension-obstructive sleep apnea2020

    • Author(s)
      Tokunou Tomotake、Ando Shin-ichi
    • Journal Title

      Hypertension Research

      Volume: 43 Issue: 12 Pages: 1338-1343

    • DOI

      10.1038/s41440-020-0494-1

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Accumulated nocturnal hypoxemia predict arterial endothelial function in patients with sleep-disordered breathing with or without chronic heart failure.2020

    • Author(s)
      Hiroyuki Sawatari, Akiko Chishaki, Mari Nishizaka, Mami Miyazono, Tomotake Tokunou, Chie Magota, Umpei Yamamoto, Sakiko Shimizu Handa, Shin-ichi Ando
    • Journal Title

      Heart and Vessels

      Volume: 1 Issue: 6 Pages: 1557-1557

    • DOI

      10.1007/s00380-020-01557-5

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 組織低酸素がもたらす全身性の病態変化2020

    • Author(s)
      得能智武、安藤眞一
    • Journal Title

      THE LUNG perspectives

      Volume: 28 Pages: 27-30

    • Related Report
      2019 Research-status Report
  • [Journal Article] Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension.2019

    • Author(s)
      Kojima H, Tokunou T, Takahara Y, Sunagawa K, Hirooka Y, Ichiki T, Tsutsui H.
    • Journal Title

      Physiological Reports

      Volume: 7 Issue: 7 Pages: e14025-e14025

    • DOI

      10.14814/phy2.14025

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α2019

    • Author(s)
      Yoshihiro Higuchi, Takuro Niidome, Yuji Miyamoto, Yoshihiro Komohara, Tomotake Tokunou, Toru Kubota, Takahiko Horiuchi
    • Journal Title

      Heart and Vessels

      Volume: 34 Issue: 3 Pages: 538-544

    • DOI

      10.1007/s00380-018-1241-2

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Telomere shortening is accelerated in a gender-differential manner in patients with insomnia receiving sleep medication.2019

    • Author(s)
      Tomotake Tokunou, Toyoki Maeda, Takahiko Horiuchi, Naoki Makino
    • Organizer
      5th Asean Sleep Federation Congress
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] Accumulation of Gold Nano-rods in the Failing Heart of Transgenic Mice with the Cardiac-specific Expression of TNF-α2019

    • Author(s)
      樋口義洋、得能智武、久保田徹、堀内孝彦
    • Organizer
      第83回日本循環器学会
    • Related Report
      2018 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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