Difference between medical professionals and patients in evaluating heart failure status
Project/Area Number |
18K08056
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53020:Cardiology-related
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Research Institution | Japan Research Promotion Society for Cardiovascular Diseases |
Principal Investigator |
Yoshikawa Tsutomu 公益財団法人日本心臓血圧研究振興会(臨床研究施設・研究部門), 内科医局, 副院長・部長 (20174906)
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Co-Investigator(Kenkyū-buntansha) |
香坂 俊 慶應義塾大学, 医学部(信濃町), 講師 (30528659)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Keywords | 心不全 / レジストリー / 入院期間 / 再入院 / 突然死 / 利尿薬 / 尿酸 / フレイル / レジストリ研究 / 高齢者 / レジストリ / データベース / 生活の質 / 多職種介入 / 合併症 |
Outline of Final Research Achievements |
We constructed large-scale database on decompensated heart failure in 7 major cardiovascular centers, and investigated multiple aspects of pathophysiology and clinical outcome. We revealed significance of nutritional status, length of hospital stay, multiple hospitalizations, type of diuretics, chamber size of heart failure with preserved ejection fraction, gender difference in guideline based medical therapy, effect of malnutrition on medical therapy, positive pressure ventilation, measurement of predischarge BNP level. We further elucidated change of uric acid level during hospitalization, psoas muscle mass evaluated by CT image, validation of sudden cardiac death prediction model, early and mid-term rehospitalization after discharge. These findings will shed light on the future prospect and health care policy for real world heart failure in our country.
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Academic Significance and Societal Importance of the Research Achievements |
本邦における代表的な循環器診療施設における急性心不全の診療実態が明らかとなった。海外の該当するデータベースと比較することにより、その違いはより鮮明となった。介入型臨床試験では反映されなかったより医療現場に近い心不全患者の病態、合併症、予後が明らかとなった。今後の心不全患者の医療政策を考えるうえで貴重なデータベースと考える。
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Report
(4 results)
Research Products
(60 results)
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[Journal Article] Differential Prognostic Impact of Atrial Fibrillation in Hospitalized Heart Failure Patients With Preserved Ejection Fraction According to Coronary Artery Disease Status ― Report From the Japanese Nationwide Multicenter Registry ―2020
Author(s)
Temma T, Nagai T, Watanabe M, Kamada Rui, Takahashi Y, Hagiwara H, Koya Taro, Nakao M, Omote K, Kamiya K, Iwano H, Yamamoto K, Yoshikawa T, Saito Y, Anzai T
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Journal Title
Circulation Journal
Volume: 84
Issue: 3
Pages: 397-403
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2020-02-25
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Prognostic Value of Serum Uric Acid in Hospitalized Heart Failure Patients with Preserved Ejection Fraction: From the Japanese Nationwide Multicenter Registry.2020
Author(s)
Kobayashi Y, Omote K, Nagai T, Kamiya K, Konishi T, Sato T, Kato Y, Komoriyama H, Tsujinaga S, Iwano H, Yamamoto K, Yoshikawa T, Saito Y, Anzai T
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Journal Title
Am J Cardiol
Volume: 125
Issue: 5
Pages: 772-776
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical Scenario Classification for Characterization and Outcome Prediction of Acute Decompensated Heart Failure Under Contemporary Phenotyping2019
Author(s)
Komuro J, Nagatomo Y, Mahara K, Isobe M, Goda A, Sujino Y, Mizuno A, Shiraishi Y, Kohno T, Kohsaka S, Yoshikawa T
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Journal Title
Circulation Reports
Volume: 1
Issue: 4
Pages: 162-170
DOI
NAID
ISSN
2434-0790
Year and Date
2019-04-10
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term prognostic significance of admission tricuspid regurgitation pressure gradient in hospitalized heart failure patients with preserved ejection fraction: a report from the Japanese real-world multicenter registry.2019
Author(s)
Omote, Nagai T, Kamiya K, Aikawa T, Tsujinaga S, Kato Y, Komoriyama H, Iwano H, Yamamoto K, Yoshikawa T, Saito Y, Anzai T
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Journal Title
J Card Fail
Volume: 25
Issue: 12
Pages: 978-985
DOI
Related Report
Peer Reviewed
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[Journal Article] Left ventricular outflow tract velocity time integral in hospitalised heart failure with preserved ejection fraction.2019
Author(s)
Omote K, Nagai T, Iwano H, Tsujinaga S, Kamiya K, Aikawa T, Konishi T, Sato T, Kato Y, Komoriyama H, Kobayashi Y, Yamamoto K, Yoshikawa T, Saito Y, Anzai T
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Journal Title
ESC Heart Fail
Volume: 999
Issue: 1
Pages: 999-999
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Performance of the MAGGIC heart failure risk score and its modification with the addition of discharge natriuretic peptides in Japanese acute heart failure patients2018
Author(s)
Sawano M, Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Sujino Y, Nagatomo Y, Kohno T, Anzai T, Fukuda K, Yoshikawa T
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Journal Title
ESC Heart Fail
Volume: 999
Issue: 4
Pages: 999-999
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Validation of U.S. Mortality Prediction Models for Hospitalised Heart Failure in The United Kingdom and Japan2018
Author(s)
Nagai T, Sundaram V, Shoaib A, Shiraishi Y, Kohsaka S, Rothnie KJ, Piper S, McDonagh TA, Hardman SMC, Goda A, Mizuno A, Sawano M, Rigby AS, Quint JK, Yoshikawa T, Clark AL, Anzai T, Cleland JGF
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Journal Title
Eur J Heart Fail
Volume: 20
Issue: 8
Pages: 1179-1190
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Mortality after Admission for Heart Failure in Japan Compared to The United Kingdom: Is East or West Best?2018
Author(s)
Nagai T, Sundaram V, Rothnie KJ, Quint JK, Shoaib A, Shiraishi Y, Kohsaka S, Piper S, McDonagh TA, Hardman SMC, Goda A, Mizuno A, Kohno T, Rigby AS Yoshikawa T, Clark AL, Anzai T, Cleland JGF
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Journal Title
Open Heart
Volume: 999
Issue: 2
Pages: e000811-e000811
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Outcome of Hospitalized Heart Failure in Japan and the United Kingdom Stratified by Plasma N-Terminal Pro-BNP2018
Author(s)
Shiraishi Y, Nagai T, Kohsaka S, Dicken B, Goda A, Nagatomo Y, Mizuno A, Kohno T, Rigby A, Fukuda K, Yoshikawa T, Clark AL, Cleland JGF
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Journal Title
Clin Res Cardiol
Volume: 107
Issue: 12
Pages: 1103-1110
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Validation and Recalibration of Seattle Heart Failure Model in Japanese Acute Heart Failure Patients2018
Author(s)
Shiraishi Y, Kohsaka S, Nagai T, Goda A, Mizuno A, Nagatomo Y, Sujino Y, Fukuoka R, Sawano M, Kohno T, Fukuda K, Anzai T, Shadman R, Dardas T, Clevy W, Yoshikawa T
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Journal Title
J Card Fail
Volume: 999
Issue: 7
Pages: 999-999
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Presentation] Association of short-acting versus long-acting loop diuretics with long-term outcomes in patients hospitalizaed for acute heart failure.2020
Author(s)
Imaeda S, Shiraishi Y, Niimi N, Goda A, Nagatomo Y, Nishihata K, Takei M, Toyosaki Y, Ikegami Y, Kohno T, Fukuda K, Kohsaka S, Yoshikawa T
Organizer
24th Japanese HF Society Meeting, YIA Clinical
Related Report
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[Presentation] Alteration in diuretic strategy after an update on the clinical practice guideline recommendations for acute heart failure management in Japan.2020
Author(s)
Yamazaki Y, Shiraishi Y, Kohsaka S, Goda A, Nagatomo Y, Nihihata Y, Saji M, Takei M, Toyosaki Y, Ikegami Y, Kohno T, Fukuda K, Yoshikawa T
Organizer
24th Japanese HF Society Meeting, YIA Clinical
Related Report
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[Presentation] Association with Short-acting vs. Long-acting Type Loop Diuretics and Long-term Clinical Outcomes in Patients Hospitalized with Acute Heart Failure.2020
Author(s)
Imaeda S, Shiraishi Y, Niimi N, Goda A, Nagatomo Y, Nishihata Y, Takei M, Toyosaki Y, Kohno T, Fukuda K, Kohsaka S, Yoshikawa T
Organizer
Japanese Circulation Society Meeting
Related Report
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[Presentation] The relationship between glucose level on admission and long-term clinical outcomes in patients with acute decompensated heart failure.2020
Author(s)
Chishiki T, Nagatomo Y, Goda A, Kohno T, Takei M, Nishihata Y, Saji M, Toyosaki Y, Ikegami Y, Shiji S, Shiraishi Y, Kohsaka S, Yoshikawa T
Organizer
24th Japanese HF Society Meeting
Related Report
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[Presentation] Sex difference in guideline directed medical therapy and its clinical impact in heart failure.2020
Author(s)
Kawai A, Nagatomo Y, Goda A, Kohno T, Takei M, Nishihata Y, Saji M, Toyosaki Y, Ikegami Y, Shiji S, Shiraishi Y, Kohsaka S, Yoshikawa T
Organizer
24th Japanese HF Society Meeting
Related Report
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[Presentation] Gaps in provision of guideline-based medical therapy in hospitalized heart failure with malnutrition: A report from the WET-HF registry.2020
Author(s)
Kawakubo Y, Shiraishi Y, Goda A, Nagatomo Y, Nishihata Y, Saji M, Takei M, Toyosaki Y, Ikegami Y, Shiji S, Kohno T, Fukuda K, Kohsaka S, Yoshikawa T
Organizer
24th Japanese HF Society Meeting
Related Report
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[Presentation] Association of non-invasive positive pressure ventilation use with tracheal intubation and short-term outcome in patients with acute decompensated heart failure.2020
Author(s)
Yukino M, Nagatomo Y, Goda A, Kohno T, Takei M, Nishihata Y, Saji M, Toyosaki Y, Ikegami Y, Shiji S, Shiraishi Y, Kohsaka S, Yoshikawa T
Organizer
24th Japanese HF Society Meeting
Related Report
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[Presentation] Measurement of discharge natriuretic peptide levels and its association with the outcomes in hospitalized heart failure patients.2020
Author(s)
Momoi M, Shiraishi Y, Goda A, Nagatomo Y, Nihihata Y, Saji M, Takei M, Toyosaki Y, Ikegami Y, Kohno T, Fukuda K, Kohsaka S, Yoshikawa T
Organizer
24th Japanese HF Society Meeting
Related Report
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[Presentation] Prognostic value of admission left ventricular outflow tract velocity time integral in hospitalized heart failure patients with preserved ejection fraction: a report from the JASPER registry.2019
Author(s)
Omote K, Nagai T, Kamiya K, Aikawa T, Tsujinaga S, Kato Y, Komoriyama H, Kobayashi Y, Iwano H, Yamamoto K, Yoshikawa T, Saito Y, Anzai T
Organizer
European Congress Cardiology
Related Report
Int'l Joint Research
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[Presentation] Optimal sampling in derivation studies determines performance of heart failure prognostic models2019
Author(s)
Iwakami N, Nagai T, Furukawa TA, Tajika A, Onishi A, Nishimura K, Ogawa S, Nakai M, Takegami M, Nakano H, Kawasaki Y, Alba AC, Guyatt GH, Shiraishi Y, Kohsaka S, Kohno T, Goda A, Mizuno A, Yoshikawa T, Anzai T
Organizer
83th Scientific Meeting of Japanese Circulation Society
Related Report
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[Presentation] Hemoconcentration-dependent predictive value of BUN/creatinine ratio at time of discharge in patients with ADHF2018
Author(s)
Sujino Y, Nakano S, Tanno J, Kanda S, Shiraishi Y, Goda A, Mizuno A, Ono M, Nagatomo Y, Kohno T, Muramatsu T, Kohsaka S, Yoshikawa T
Organizer
66th Annual Scientific Session of Japanese College of Cardiology
Related Report
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[Presentation] Predicting sudden death in Japanese heart failure patients: International validation of the Seattle Proportional Risk Model2018
Author(s)
Fukuoka R, Kohno T, Kohsaka S, Shiraishi Y, Sawano M, Abe T, Nagatomo Y, Goda A, Mizuno A, Fukuda K, Shadman R, Dardes TF, Levy WC, Yoshikawa T
Organizer
ESC congress
Related Report
Int'l Joint Research
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