ProBNP processing in patients with acute heart failure and clinical application

• Project/Area Number: 18K08057
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Takahama Hiroyuki 国立研究開発法人国立循環器病研究センター, 病院, 医長 (10570301)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 心不全 / ナトリウム利尿ペプチド / BNP / リバースリモデリング / バイオマーカー / 急性心不全

Outline of Final Research Achievements

We completed the enrollment of the patients to this clinical study in October, 2020, and also competed the measurements of proBNP, total BNP and other biomarkers. We are proceeding the analysis and will open the data at scientific meeting. In the retrospective study, we showed the data the association of proBNP ratio with left ventricular reverse remodeling in patients with heart failure. Regarding the retrospective study, we are submitting the manuscript to the scientific journal in revision process.

Academic Significance and Societal Importance of the Research Achievements

心不全患者にとって左室収縮性の予測は病態予測、治療介入の決定などにおいて重要な課題であり本課題の臨床的意義は高いと考えられる。

Research Products

• [Journal Article] 急性心不全患者におけるBNP前駆体のプロセシング亢進による新しい心不全代償機構の検証 (2020)
  • Author(s): 高濱博幸
  • Journal Title: Bio Clinica Volume: 36 Pages: 250-257
• [Journal Article] HFpEFとHFrEFの病態生理と治療法の違いはバイオマーカーで説明可能か？ (2020)
  • Author(s): 高濱博幸
  • Journal Title: Heart View Volume: 10 Pages: 84-87
• [Journal Article] Change in the NT‐proBNP/Mature BNP Molar Ratio Precedes Worsening Renal Function in Patients With Acute Heart Failure: A Novel Predictor Candidate for Cardiorenal Syndrome (2019)
  • Author(s): Takahama Hiroyuki、Nishikimi Toshio、et al
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 17
  • DOI: 10.1161/jaha.118.011468
  • NAID: 120006878493
  • Peer Reviewed / Open Access
• [Journal Article] Superiority of proatrial natriuretic peptide in the prognostic power in patients with acute decompensated heart failure on hospital admission: comparison with B-type natriuretic peptide and other natriuretic peptide forms (2019)
  • Author(s): Takashio Seiji、Takahama Hiroyuki、et al.
  • Journal Title: Open Heart Volume: 6 Issue: 2 Pages: e001072-e001072
  • DOI: 10.1136/openhrt-2019-001072
  • NAID: 120006878492
  • Peer Reviewed / Open Access
• [Journal Article] Ratio of pro-B-type natriuretic peptide (BNP) to total BNP is decreased in mild, but not severe, acute decompensated heart failure patients: A novel compensatory mechanism for acute heart failure (2018)
  • Author(s): Takahama Hiroyuki、Takashio Seiji、Nishikimi Toshio、Hayashi Tomohiro、Nagai-Okatani Chiaki、Nakagawa Yasuaki、Amaki Makoto、Ohara Takahiro、Hasegawa Takuya、Sugano Yasuo、Kanzaki Hideaki、Yasuda Satoshi、Kangawa Kenji、Minamino Naoto、Anzai Toshihisa
  • Journal Title: International Journal of Cardiology Volume: 258 Pages: 165-171
  • DOI: 10.1016/j.ijcard.2017.12.047
  • Peer Reviewed
• [Journal Article] Plasma soluble neprilysin levels are unchanged during recovery after decompensation of heart failure: a matter of the magnitude of the changes in systemic haemodynamics? (2018)
  • Author(s): Takahama H, et al.
  • Journal Title: European Heart Journal Volume: 39 Issue: 37 Pages: 3472-3473
  • DOI: 10.1093/eurheartj/ehy454
• [Presentation] Reduced effectiveness of natriuretic peptide in patients with severe heart failure: Is neurohormonal imbalance the key for therapy? (2021)
  • Author(s): Takahama H
  • Organizer: 日本循環器学会
• [Presentation] Association of proBNP ratio to total BNP on admission with future cardiac reverse remodeling in acute decompensated heart failure patients with reduced ejection fraction (2019)
  • Author(s): Kimura A, Takahama H et al.
  • Organizer: American Heart Association
  • Int'l Joint Research
• [Presentation] Superior predictability of proANP level on admission for clinical outcomes in acute heart failure patients: Comparison with proBNP and BNP (2018)
  • Author(s): 高濱博幸
  • Organizer: 日本循環器学会
• [Presentation] Impact of the superior predicting ability of pro-atrial natriuretic peptide level on admission for future clinical adverse events in patients with acute heart failure: Comparison with B-type natriuretic peptide level measured using conventional assay (2018)
  • Author(s): Takahama H
  • Organizer: America Heart Association
  • Int'l Joint Research
• [Presentation] Increased proBNP ratio to total BNP in heart failure patients after discharge: Is glycosylation of proBNP essential for cardiac homeostasis? (2018)
  • Author(s): 高濱博幸
  • Organizer: 日本心不全学会