| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
The proriferation level and migration level decreased after human cardiac myofibroblast were exposed to stretch. The protein expression level of fibrosis marker also decreased in response to stretch. It indicates that stretch induces de-differentiation of myofibroblast. Next the knockdown of TRPV4 which was an carcium ion channel in myofibroblast did not respond to stretch. These findings indicate that one of the cause of cardiac fibrosis is the decrease of stretch, the increase of TRPV4, and the increase of fibrosis.
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