Investigation of the role of the adaptive immunity in cardiovascular disease and development of therapeutic strategies
| Project/Area Number |
18K08088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
Sasaki Naoto 神戸薬科大学, 薬学部, 准教授 (00514746)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 動脈硬化 / 大動脈瘤 / 心不全 / 炎症 / 免疫 / 高血圧 |
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| Outline of Final Research Achievements |
Immunoinflammatory responses are critically involved in the development of atherosclerotic cardiovascular diseases. Using various mouse models of atherosclerotic diseases, we identified a novel target and an immunomodulatory strategy to prevent these diseases. We reported that the immunoregulatory molecule cytotoxic T lymphocyte antigen-4 (CTLA-4) plays a critical role in limiting the development of abdominal aortic aneurysm by suppressing aortic immunoinflammatory responses. Ultraviolet B (UVB) irradiation is known to dampen immunoinflammatory reactions. We found that broad-band UVB irradiation inhibits the onset and development of heart failure associated with myocardial infarction. We also identified UVB wavelengths effective in preventing atherosclerosis.
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| Academic Significance and Societal Importance of the Research Achievements |
我が国での動脈硬化性疾患は、癌についで死亡原因の第２位となっており、その発症機序の解明や有効な治療・予防法の開発が切に望まれている。大動脈瘤には外科的治療が行われるが、合併症のリスクが高く、非侵襲的な治療法の開発が必要である。本研究で見出したCTLA-4の機能を模倣した薬剤は、関節リウマチの治療に用いられており、大動脈瘤の治療への応用が期待される。UVB療法は、経済的負担が少なく安全な治療法として皮膚科領域で臨床応用されている。近年、動脈硬化性疾患に対する治療は医療経済を圧迫しているが、UVB療法は経済的負担の少ない治療法として期待され、新規治療法として臨床応用を実現したい。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] CTLA-4 Protects against Angiotensin II-Induced Abdominal Aortic Aneurysm Formation in Mice.2019
Author(s)
Amin HZ, Sasaki N, Yamashita T, Mizoguchi T, Hayashi T, Emoto T, Matsumoto T, Yoshida N, Tabata T, Horibe S, Kawauchi S, Rikitake Y, Hirata KI
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Journal Title
Scientific Reports
Volume: 9(1)
Issue: 1
Pages: 8065-8065
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Presentation] Overexpression of cytotoxic T-lymphocyte-associated antigen-4 suppresses aortic immunoinflammatory responses and prevents angiotensin II-induced abdominal aortic aneurysm formation in mice.2019
Author(s)
Hilman Zulkifli Amin, Naoto Sasaki, Tomoya Yamashita, Taiji Mizoguchi, Tomohiro Hayashi, Takuo Emoto, Takuya Matsumoto, Naofumi Yoshida, Tokiko Tabata, Sayo Horibe, Shoji Kawauchi, Yoshiyuki Rikitake, Ken-ichi, Hirata
Organizer
European Society of Cardiology Congress, 2019
Related Report
Int'l Joint Research
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[Presentation] Overexpression of cytotoxic T-lymphocyte-associated antigen-4 suppresses aortic immunoinflammatory responses and prevents angiotensin II-induced abdominal aortic aneurysm formation in mice.2019
Author(s)
Hilman Zulkifli Amin, Naoto Sasaki, Tomoya Yamashita, Taiji Mizoguchi, Tomohiro Hayashi, Takuo Emoto, Takuya Matsumoto, Naofumi Yoshida, Tokiko Tabata, Sayo Horibe, Shoji Kawauchi, Yoshiyuki Rikitake, Ken-ichi, Hirata
Organizer
European Society of Cardiology Asia Congress 2019
Related Report
Int'l Joint Research / Invited
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[Presentation] Overexpression of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) protects against abdominal aortic aneurysm formation in mice.2019
Author(s)
Hilman Zulkifli Amin, Naoto Sasaki, Tomoya Yamashita, Taiji Mizoguchi, Tomohiro Hayashi, Takuo Emoto, Takuya Matsumoto, Naofumi Yoshida, Tokiko Tabata, Sayo Horibe, Shoji Kawauchi, Yoshiyuki Rikitake, Ken-ichi Hirata
Organizer
第83回日本循環器学会学術集会
Related Report
Invited
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