Significance of APE1 as a Diagnostic and Therapeutic Target Molecule in Onco-Cardiology

• Project/Area Number: 18K08093
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Asahikawa Medical College
• Principal Investigator: Hasebe Naoyuki 旭川医科大学, 医学部, 教授 (30192272)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 化学療法誘発性心筋傷害 / ドキソルビシン / APE1 / バイオマーカー / 化学療法誘発性心筋障害 / 腫瘍循環器学 / アントラサイクリン系抗癌剤 / 酸化ストレス / 心不全

Outline of Final Research Achievements

There have been no biomarkers and no curative measures for doxorubicin (DOX) cardiotoxicities. We proposed APE1 as a potential target molecule to solve this issue. APE1 is multifunctional, with repairing DNA damage and antioxidative functions. A DOX mouse model demonstrated an enhanced APE1 expression, parallel with progression of cardiac dysfunction dose-dependently to DOX, suggesting a possible role of APE1 as a significant biomarker of DOX cardiotoxicity. APE1 gene transfection reduced myocardial damage in DOX cardiotoxicity model. Advanced experiments on dose-dependency of cardioprotective effects of APE1 has been progressing.

Academic Significance and Societal Importance of the Research Achievements

我々はこれまで動脈硬化性心血管リモデリングにおける新たな診断治療標的分子としてのAPE1の意義を確立してきた。癌化学療法誘発性心血管障害におけるAPE1の意義は、診断的にも治療的にも全く明らかにされていない。本研究は、これまでのAPE1の循環器学的知見を腫瘍学の領域に展開し、DOX誘発心筋障害のバイオマーカーとしての診断的意義と、心筋障害軽減の標的分子としての治療的意義を解明するものであり、独創性に富み将来の臨床適用に繋がる発展性ある研究である。その成果は、腫瘍循環器学領域における新たな学術的意義と同時に癌サバイバーの長期予後の改善という社会的意義を有し、医療社会学の発展に資するものである。

Research Products

• [Journal Article] Characteristics of Neurological Symptoms in Adult Japanese Patients with Fabry Disease (2021)
  • Author(s): Sawada Jun、Nakagawa Naoki、Kano Kohei、Saito Tsukasa、Katayama Takayuki、Sawada Takaaki、Momosaki Ken、Nakamura Kimitoshi、Hasebe Naoyuki
  • Journal Title: Internal Medicine Volume: 60 Issue: 12 Pages: 1819-1826
  • DOI: 10.2169/internalmedicine.6420-20
  • NAID: 130008052662
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-06-15
  • Peer Reviewed / Open Access
• [Journal Article] Antimitochondrial Antibody-associated Myopathy with Slowly Progressive Cardiac Dysfunction (2021)
  • Author(s): Takahashi F, Sawada J, Minoshima A, Sakamoto N, Ono T, Akasaka K, Takei H, Nishino I, Hasebe N.
  • Journal Title: Internal Medicine Volume: 60 Issue: 7 Pages: 1035-1041
  • DOI: 10.2169/internalmedicine.5600-20
  • NAID: 130008014366
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-04-01
  • Peer Reviewed / Open Access
• [Journal Article] Acute Myocardial Infarction in a 17-year-old High-school Girl (2021)
  • Author(s): Kawaguchi S, Hasebe T, Ohta H, Kikuchi A, Asanome A, Nishiura T, Sakamoto N, Tanabe Y, Takeuchi T, Sato N, Kawamura Y, Hasebe N.
  • Journal Title: Internal Medicine Volume: 60 Issue: 2 Pages: 259-263
  • DOI: 10.2169/internalmedicine.5437-20
  • NAID: 130007968963
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2021-01-15
  • Peer Reviewed / Open Access
• [Journal Article] High prevalence of masked uncontrolled morning hypertension in elderly non-valvular atrial fibrillation patients: Home blood pressure substudy of the ANAFIE Registry. (2021)
  • Author(s): Kario K, Hasebe N, Okumura K, Yamashita T, Akao M, Atarashi H, Ikeda T, Koretsune Y, Shimizu W, Tsutsui H, Toyoda K, Hirayama A, Yasaka M, Yamaguchi T, Teramukai S, Kimura T, Kaburagi J, Takita A, Inoue H.
  • Journal Title: J Clin Hypertens Volume: 23 Issue: 1 Pages: 73-82
  • DOI: 10.1111/jch.14095
  • Peer Reviewed / Open Access
• [Journal Article] Potential common pathophysiological pathway of hypertension-mediated organ damage in hypertensive emergency (2021)
  • Author(s): Nakagawa N, Hasebe N.
  • Journal Title: Hypertens Res. Volume: 44 Issue: 1 Pages: 124-125
  • DOI: 10.1038/s41440-020-00575-0
  • Peer Reviewed
• [Journal Article] Malignant hypertension and multiorgan damage: mechanisms to be elucidated and countermeasures. (2021)
  • Author(s): Saito T, Hasebe N.
  • Journal Title: Hypertens Res. Volume: 44 Issue: 1 Pages: 122-123
  • DOI: 10.1038/s41440-020-00555-4
  • Peer Reviewed
• [Journal Article] The First Case of Spinocerebellar Ataxia Type 8 in Monozygotic Twins (2020)
  • Author(s): Sawada J, Katayama T, Tokashiki T, Kikuchi S, Kano K, Takahashi K, Saito T, Adachi Y, Okamoto Y, Yoshimura A, Takashima H, Hasebe N.
  • Journal Title: Internal Medicine Volume: 59 Issue: 2 Pages: 277-283
  • DOI: 10.2169/internalmedicine.2905-19
  • NAID: 130007785008
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-01-15
  • Peer Reviewed / Open Access
• [Journal Article] Imaging and pathological evaluation of deep intramural ventricular tachycardia after combined bipolar and ethanol ablation (2020)
  • Author(s): Sakamoto N, Komatsu Y, Otsu K, Kamikokura Y, Hontani M, Sugiyama E, Minoshima A, Tanabe Y, Sekiguchi Y, Tanino M, Sato N, Kawamura Y, Nogami A, Aonuma K, Hasebe N.
  • Journal Title: JACC Clin Electrophysiol Volume: 6 Issue: 14 Pages: 1865-1866
  • DOI: 10.1016/j.jacep.2020.08.040
  • Peer Reviewed
• [Journal Article] Assessment of suitable antihypertensive therapies: Combination with high‐dose amlodipine/irbesartan vs triple combination with amlodipine/irbesartan/indapamide (ASAHI‐AI study) (2020)
  • Author(s): Nakagawa Naoki、Sato Nobuyuki、Saijo Yasuaki、Morimoto Hideo、Koyama Satoshi、Ogawa Yuji、Uekita Kazumi、Maruyama Junichi、Ohta Takafumi、Nakamura Yasuhiro、Takeuchi Toshiharu、Hasebe Naoyuki、the ASAHI‐AI investigators
  • Journal Title: The Journal of Clinical Hypertension Volume: 22 Issue: 9 Pages: 1577-1584
  • DOI: 10.1111/jch.13977
  • Peer Reviewed / Open Access
• [Journal Article] EphA7+ perivascular cells as myogenic and angiogenic precursors improving skeletal muscle regeneration in a muscular dystrophic mouse model (2020)
  • Author(s): Kano Kohei、Horiuchi Kiwamu、Yoshida Yuri、Hayasaka Taiki、Kabara Maki、Tomita Yui、Tatsukawa Takamitsu、Matsuo Risa、Sawada Jun、Nakagawa Naoki、Takehara Naofumi、Hasebe Naoyuki、Kawabe Jun-ichi
  • Journal Title: Stem Cell Research Volume: 47 Pages: 101914-101914
  • DOI: 10.1016/j.scr.2020.101914
  • Peer Reviewed / Open Access
• [Journal Article] Japanese Heart Failure Society 2018 Scientific Statement on Nutritional Assessment and Management in Heart Failure Patients (2020)
  • Author(s): Yamamoto K、Tsuchihashi-Makaya M、Kinugasa Y、Iida Y、Kamiya K、Kihara Y、Kono Y、Sato Y、Suzuki N、Takeuchi H、Higo T、Miyazawa Y、Miyajima I、Yamashina A、Yoshita K、Washida K、Kuzuya M、Takahashi T、Nakaya Y、Hasebe N、Tsutsui H.
  • Journal Title: Circulation Journal Volume: 84 Issue: 8 Pages: 1408-1444
  • DOI: 10.1253/circj.cj-20-0322
  • NAID: 130007879390
  • Peer Reviewed / Open Access
• [Journal Article] Physician and patient perspectives on hypertension management and factors associated with lifestyle modifications in Japan: results from an online survey (2020)
  • Author(s): Nishigaki Nobuhiro、Shimasaki Yukio、Yoshida Takuo、Hasebe Naoyuki
  • Journal Title: Hypertension Research Volume: 43 Issue: 5 Pages: 450-462
  • DOI: 10.1038/s41440-020-0398-0
  • Peer Reviewed
• [Journal Article] Perspectives of patients and physicians regarding hypertensive management from an online survey for excellence: a subanalysis of the PARADOX study by physician categories. (2020)
  • Author(s): Yoshida T, Nishigaki N, Saita S, Shimasaki Y, Hasebe N.
  • Journal Title: Hypertens Res Volume: 43 Issue: 5 Pages: 431-441
  • DOI: 10.1038/s41440-019-0365-9
  • Peer Reviewed
• [Journal Article] β(3)-Adrenergic receptor blockade reduces mortality in endotoxin-induced heart failure by suppressing induced nitric oxide synthase and saving cardiac metabolism. (2020)
  • Author(s): 1)Kawaguchi S, Okada M, Ijiri E, Koga D, Watanabe T, Hayashi K, Kashiwagi Y, Fujita S, Hasebe N.
  • Journal Title: Am J Physiol Heart Circ Physiol Volume: 318 Issue: 2 Pages: H283-H294
  • DOI: 10.1152/ajpheart.00108.2019
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cerebrospinal fluid levels of alpha-synuclein, amyloid β, tau, phosphorylated tau, and neuron-specific enolase in patients with Parkinson's disease, dementia with Lewy bodies or other neurological disorders: Their relationships with cognition and nuclear medicine imaging findings. (2020)
  • Author(s): Katayama T, Sawada J, Kikuchi-Takeguchi S, Kano K, Takahashi K, Saito T, Okizaki A, Hasebe N.
  • Journal Title: Neurosci Lett Volume: 715 Pages: 1346564-1346564
  • DOI: 10.1016/j.neulet.2019.134564
  • Peer Reviewed
• [Journal Article] Capillary-resident EphA7(+) pericytes are multipotent cells with anti-ischemic effects through capillary formation. (2020)
  • Author(s): Yoshida Y, Kabara M, Kano K, Horiuchi K, Hayasaka T, Tomita Y, Takehara N, Minoshima A, Aonuma T, Maruyama K, Nakagawa N, Azuma N, Hasebe N, Kawabe JI.
  • Journal Title: Stem Cells Transl Med Volume: 9 Issue: 1 Pages: 120-130
  • DOI: 10.1002/sctm.19-0148
  • Peer Reviewed / Open Access
• [Journal Article] Anti-signal Recognition Particle Antibody-positive Necrotizing Myopathy with Secondary Cardiomyopathy: The First Myocardial Biopsy- and Multimodal Imaging-proven Case (2019)
  • Author(s): Takeguchi-Kikuchi S, Hayasaka T, Katayama T, Kano K, Takahashi K, Saito T, Sawada J, Minoshima A, Sakamoto N, Akasaka K, Miyokawa N, Nishino I, Ishibashi-Ueda H, Hasebe N.
  • Journal Title: Internal Medicine Volume: 58 Issue: 21 Pages: 3189-3194
  • DOI: 10.2169/internalmedicine.2564-18
  • NAID: 130007740773
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-11-01
  • Peer Reviewed
• [Journal Article] Diffuse Alveolar Hemorrhaging with Hypertensive Emergency: A Rare but Important Cause of Hemoptysis (2019)
  • Author(s): Suzuki A, Nakagawa N, Maruyama K, Matsuki M, Hasebe N.
  • Journal Title: Internal Medicine Volume: 58 Issue: 10 Pages: 1511-1516
  • DOI: 10.2169/internalmedicine.0920-18
  • NAID: 130007649814
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2019-05-15
  • Peer Reviewed
• [Journal Article] Case of Invasive <i>Streptococcus Dysgalactiae</i> Infection Presenting as Infective Endocarditis with Multiple Brain Embolisms (2019)
  • Author(s): Takahashi F, Wada Y, Hasebe N
  • Journal Title: International Heart Journal Volume: 60 Issue: 1 Pages: 204-207
  • DOI: 10.1536/ihj.17-700
  • NAID: 130007557150
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2019-01-31
• [Journal Article] Unexpectedly High Prevalence of Coronary Spastic Angina in Patients With Anderson-Fabry Disease (2019)
  • Author(s): Kitani Y, Nakagawa N, Sakamoto N, Takeuchi T, Takahashi F, Momosaki K, Nakamura K, Endo F, Maruyama H, Hasebe N.
  • Journal Title: Circulation Journal Volume: 83 Issue: 2 Pages: 481-484
  • DOI: 10.1253/circj.CJ-18-0734
  • NAID: 130007557008
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-01-25
  • Peer Reviewed
• [Journal Article] Antithrombotic Therapy for Atrial Fibrillation with Stable Coronary Disease. (2019)
  • Author(s): Yasuda S, Kaikita K, Akao M, Ako J, Matoba T, Nakamura M, Miyauchi K, Hagiwara N, Kimura K, Hirayama A, Matsui K, Ogawa H
  • Journal Title: N Engl J Med. Volume: 381 Issue: 12 Pages: 1103-1113
  • DOI: 10.1056/nejmoa1904143
  • Peer Reviewed
• [Journal Article] Novel Detection of CALR-Mutated Cells in Myeloproliferative Neoplasm-Related Glomerulopathy With Interstitial Extramedullary Hematopoiesis: A Case Report. (2019)
  • Author(s): Maruyama K, Nakagawa N, Suzuki A, Kabara M, Matsuki M, Shindo M, Iwasaki S, Ogawa Y, Hasebe N.
  • Journal Title: Am J Kidney Dis. Volume: 74 Issue: 6 Pages: 844-848
  • DOI: 10.1053/j.ajkd.2019.05.016
  • Peer Reviewed
• [Journal Article] Japanese Society of Hypertension Working Group on the COmparison of Self-measured home, Automated unattended office and Conventional attended office blood pressure (COSAC) study. Comparison of blood pressure values-self-measured at home, measured at an unattended office, and measured at a conventional attended office. (2019)
  • Author(s): Asayama K, Ohkubo T, Rakugi H, Miyakawa M, Mori H, Katsuya T, Ikehara Y, Ueda S, Ohya Y, Tsuchihashi T, Kario K, Miura K, Hasebe N, Ito S, Umemura S
  • Journal Title: Hypertens Res Volume: 42 Issue: 11 Pages: 1726-1737
  • DOI: 10.1038/s41440-019-0287-6
  • Peer Reviewed
• [Journal Article] High-risk screening for Anderson?Fabry disease in patients with cardiac, renal, or neurological manifestations (2019)
  • Author(s): Nakagawa Naoki、Sawada Jun、Sakamoto Naka、Takeuchi Toshiharu、Takahashi Fumihiko、Maruyama Jun-ich、Momosaki Ken、Nakamura Kimitoshi、Endo Fumio、Hasebe Naoyuki
  • Journal Title: Journal of Human Genetics Volume: 64 Issue: 9 Pages: 891-898
  • DOI: 10.1038/s10038-019-0633-1
  • Peer Reviewed
• [Journal Article] Left-Dominant Arrhythmogenic Cardiomyopathy With Heterozygous Mutations in DSP and MYBPC3. (2019)
  • Author(s): Sakamoto N, Natori S, Hosoguchi S, Minoshima A, Noro T, Akasaka K, Sato N, Ohno S, Ikeda Y, Ishibashi-Ueda H, Horie M, Hasebe N.
  • Journal Title: Circ Cardiovasc Imaging Volume: 12 Issue: 6
  • DOI: 10.1161/circimaging.119.008913
  • Peer Reviewed
• [Journal Article] The antioxidant and DNA-repair enzyme apurinic/apyrimidinic endonuclease 1 limits the development of tubulointerstitial fibrosis partly by modulating the immune system (2019)
  • Author(s): Maruyama K, Nakagawa N, Aonuma T, Saito Y, Hayasaka T, Kano K, Horiuchi K, Takehara N, Kawabe JI, Hasebe N.
  • Journal Title: Sci Rep. Volume: 9 Issue: 1 Pages: 7823-7823
  • DOI: 10.1038/s41598-019-44241-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] JSH Statement: Asahikawa declaration in promotion of diversity by the Japanese society of hypertension-the JSH Asahikawa declaration. (2019)
  • Author(s): Nakamura S, Hasebe N, Yatabe M, Kishi T, Ishida M, Ichihara A, Node K, Ishimitsu T, Itoh H, Ito M, Ohishi M, Ohkubo T, Kai H, Kashihara N, Kario K, Saitoh S, Tsuchihashi T, Nishiyama A, Higaki J, Miura K, Rakugi H, Kawano Y, Tamura K, Yatabe T, Ohya Y, Ito S
  • Journal Title: Hypertens Res. Volume: 42 Issue: 10 Pages: 1483-1484
  • DOI: 10.1038/s41440-019-0261-3
  • Peer Reviewed
• [Journal Article] Impact of the 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines on the Next Blood Pressure Guidelines in Asia (2019)
  • Author(s): Nakagawa N, Hasebe N
  • Journal Title: Curr Hypertens Rep Volume: 10 Issue: 1 Pages: 2-21
  • DOI: 10.1007/s11906-019-0906-2
  • Peer Reviewed / Open Access
• [Journal Article] JSH Statement: Kyoto declaration on hypertension research in Asia. (2019)
  • Author(s): Ito M, Ishimitsu T, Ichihara A, Itoh H, Ohishi M, Ohkubo T, Kai H, Kashihara N, Kario K, Saitoh S, Tsuchihashi T, Nakamura S, Nishiyama A, Node K, Hasebe N, Higaki J, Miura K, Rakugi H, Tamura K, Kawano Y, Yatabe T, Ohya Y, Ito S.
  • Journal Title: Hypertens Res Volume: 42 Issue: 6 Pages: 759-760
  • DOI: 10.1038/s41440-018-0172-8
• [Journal Article] Efficacy of Endocardial Ablation of Drug-Resistant Ventricular Fibrillation in Brugada Syndrome. (2018)
  • Author(s): Talib AK, Hasebe N et al
  • Journal Title: Circ Arrhythm Electrophysiol Volume: 11 Issue: 8
  • DOI: 10.1161/circep.117.005631
  • Peer Reviewed / Open Access
• [Journal Article] Pericyte-Specific Ninjurin1 Deletion Attenuates Vessel Maturation and Blood Flow Recovery in Hind Limb Ischemia. (2018)
  • Author(s): Minoshima A, Hasebe N et al
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 38 Issue: 10 Pages: 2358-2370
  • DOI: 10.1161/atvbaha.118.311375
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Pazopanib-induced Endothelial Injury with Podocyte Changes (2018)
  • Author(s): Maruyama K, Hasebe N et al
  • Journal Title: Internal Medicine Volume: 57 Issue: 7 Pages: 987-991
  • DOI: 10.2169/internalmedicine.9576-17
  • NAID: 130006602631
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed
• [Presentation] Overview of Hypertension in Asia (2020)
  • Author(s): Naoyuki Hasebe
  • Organizer: Asian Pacific Society of Cardiology 2020
  • Int'l Joint Research / Invited
• [Presentation] How to Utilize JSH 2019 Hypertension Guidelines in Clinical Practice of Cardiovascular Medicine (2020)
  • Author(s): Naoyuki Hasebe
  • Organizer: The 84th Annual Scientific Meeting of the Japanese Circulation Society (JCS2020)
  • Int'l Joint Research / Invited
• [Presentation] 若い時にこそ健康長寿を目指そう (2020)
  • Author(s): 長谷部直幸
  • Organizer: 第84回日本循環器学会学術集会(JCS2020)
  • Invited
• [Presentation] 糖尿病と癌 (2020)
  • Author(s): 長谷部直幸
  • Organizer: 第3回日本腫瘍循環器学会
  • Invited
• [Presentation] 高血圧パラドックス解消に向けた市民啓発の取り組み “高血圧の川柳・標語コンテストの取り組み” (2020)
  • Author(s): 長谷部直幸
  • Organizer: 第2回Digital Hypertension Conference
  • Invited
• [Presentation] Pericyte-specific deletion of ninjurin1 induces abnormal vasa vasorum formation and persistent inflammation and enhances intimal hyperplasia of injured vasculature (2019)
  • Author(s): Horiuchi K,Minoshima A,Kabara M,Kano K,Tomita Y, Yoshida Y,Hayasaka T,Takehara N,Hasebe N,Kawabe J
  • Organizer: ESC Congress 2019 Paris Frane, 8/31-9/4,2019
  • Int'l Joint Research
• [Presentation] Apurinic/apyrimidinic endonuclease 1 (APE1) , an antioxidant and DNA-repair enzyme, has a renoprotective effect during kidney injury (2019)
  • Author(s): Maruyama K, Nakagawa N, Hasebe N
  • Organizer: ISN 2019, Melbourne, Australia, 4/12-15, 2019
  • Int'l Joint Research
• [Presentation] Cardiac Metabolism Was Improved by Regulation of Nitric Oxide Synthases Through the Beta-3 Adrenergic Receptor in Endotoxin-induced Failing Heart (2019)
  • Author(s): Okada M, Kawaguchi S, Fujita S, Hasebe N
  • Organizer: AHA2019, Philadelphia,USA, 11/16-18,2019
  • Int'l Joint Research
• [Presentation] 周細胞特異的 Ninjurin1欠損は、障害血管外膜 vasa vasorum の形成異常と血管内膜肥厚の増悪をもたらす (2019)
  • Author(s): 堀内至、蓑島暁帆、鹿原真樹、早坂太希、吉田有里、富田唯、鹿野耕平、竹原有史、長谷部直幸、川辺淳一
  • Organizer: 第48回日本心脈管作動物質学会
• [Presentation] EphA7 陽性周細胞=&#12113;細&#12174;管幹細胞(Capillary Stem Cells, CapSCs)の同定とその下肢虚&#12174;改善効果の検討 (2019)
  • Author(s): 吉田有里、鹿原真樹、鹿野耕平、早坂太希、富田唯、堀内至、竹原有史、長谷部直幸、川辺淳一、東信良
  • Organizer: 第 31 回 代&#12132;臓器・再&#12131;医学研究会総会
• [Presentation] 後天性免疫不全症候群・梅毒・抗カルジオリピン抗体陽性を伴った若年性再発性脳梗塞の１例 (2019)
  • Author(s): 片山隆行、菊地（竹口）史織、鹿野耕平、髙橋佳恵、齋藤司、澤田潤、長谷部直幸、進藤基博、本間 大
  • Organizer: 第44回 日本脳卒中学会学術集会
• [Presentation] D-dimer Cutoff Value for the Diagnosis of Deep Vein Thrombosos in the Patients with Cancer (2019)
  • Author(s): 井上仁喜、杉山英太郎 、山本清二 、長谷部直幸
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Clinical Significance of Intraluminal Intensity of Blood Speckle after Revascularization in Acute Myocardial Infarction (2019)
  • Author(s): 菅野貴康、石井良直 、田中義範 、北川拓 、小林祐也、鈴木伸穂 、浅野目晃 、井澤和眞 、長谷部直幸
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Usefulness of Heart Rate Efficiency Compared to Peak O2 Pluse in Patients with Chronic Heart Failure (2019)
  • Author(s): Date A, Hayasaka T, Hosoguchi S, Koizumi Y, Minoshima A, Sakamoto N, Hasebe N
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Malnutrition and Risk of Contract-Induced Acute Kidney Injury in the Elderly Patients after Percutaneous Coronary Intervention (2019)
  • Author(s): 山内敦司、中川直樹、柴山佳一郎、平井俊浩、鈴木孝英、貴田岡享、小川裕二、長谷部直幸
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Ninj 1 Improves Tissue Ischemia through Maturation of Micro vessels independently of Collateral Circulation (2019)
  • Author(s): Minoshima A, Kawabe J, Matsuki M, Kabara M, Horiuchi K, Saito Y, Hayasaka T, Takehara N, Hasebe N
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Tail-suspention Induced Sarcopenia is Assosiated with a Cardio-repair Malfunction after Myocardial Infarction in Mice (2019)
  • Author(s): 早坂太希、竹原有史、堀内至、川辺淳一、長谷部直幸
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Diagnostic utility of magnetic resonance imaging and angiography in patients with Fabry disease (2019)
  • Author(s): Sawada J, Kikuchi S, Takahashi K, Saito T, Katayama T, Nakagawa N, Momosaki K, Nakamura K, Hasebe N
  • Organizer: 第60回日本神経学会学術大会
• [Presentation] 多分化能を有する毛細血管幹細胞(Capillary Stem Cells, CapSCs)の同定とその組織再生能・虚血改善効果の検討 (2019)
  • Author(s): 吉田有里、鹿原真樹、鹿野耕平、早坂太希、富田唯、堀内至、蓑島暁帆、齊藤幸裕、竹原有史、長谷部直幸、東信良、川辺 淳一
  • Organizer: 第47回日本血管外科学会学術総会、
• [Presentation] 橘内博哉、滝山由美、中川直樹、長谷部直幸、佐々木智章、沖崎貴琢、竹内文也、羽田勝計、太田嗣人 (2019)
  • Author(s): MRI拡散強調画像解析を用いた糖尿病腎症診断法の開発
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 日常生活状態における骨格筋組織の再生・維持に毛細血管周細胞が重要である (2019)
  • Author(s): 鹿野耕平、内田紗瑛子、鈴木勇太、田中洋子、田丸祐也、中島恵一、堀内至、澤田潤、長谷部直幸、川辺淳一
  • Organizer: 第61回日本老年医学会学術集会
• [Presentation] 新規体性幹細胞＝毛細血管幹細胞（Capillary Stem Cells;CapSCs）による骨格筋再生能 (2019)
  • Author(s): 鹿野耕平、鹿原真樹、吉田有里、堀内至、早坂太希、富田唯、澤田潤、竹原有史、長谷部直幸、川辺淳一
  • Organizer: 第61回日本老年医学会学術集会
• [Presentation] 難治性ネフローゼ症候群に対するリツキシマブの有効性についての検討 (2019)
  • Author(s): 佐久間寛史、丸山啓介、松木孝樹、中川直樹、藤野貴行、長谷部直幸
  • Organizer: 第62回日本腎臓学会学術総会
• [Presentation] ループス腎炎におけるAPE1とヒストンH3-K4トリメチル化の役割―酸化ストレス産生との関連 (2019)
  • Author(s): 藤野貴行、山田夏生、松田正大、林望美、佐久間寛史、松木孝樹、中川直樹、佐藤伸之、長谷部直幸
  • Organizer: 第62回日本腎臓学会学術総会
• [Presentation] 閉塞性動脈硬化症におけるシャントトラブルスコアリングによる評価の検討 (2019)
  • Author(s): 土田裕樹、延藤優太、天内雅人、本吉宣也、山﨑大輔、成田孝行、宗万孝次、松木孝樹、長谷部直幸、谷本幸代、佐々木央子、種村佐織、大内直美
  • Organizer: 第64回日本透析医学会学術集会・総会、
• [Presentation] 閉塞性動脈硬化症患者の周術期における慢性維持透析での回路内残血の検討 (2019)
  • Author(s): 中山克明、延藤優太、天内雅人、成田孝行、宗万孝次、松木孝樹、長谷部直幸
  • Organizer: 第64回日本透析医学会学術集会・総会、
• [Presentation] 二度の急性心膜炎を契機に冠攣縮性狭心症(CSA)を発症した一例 (2019)
  • Author(s): 北川拓、小林祐也、浅野目晃、井澤和眞、菅野貴康、石井良直、長谷部直幸
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] 冠動脈疾患における血流依存性血管拡張反応(FMD)と冠危険因子の検討 (2019)
  • Author(s): 小林祐也、石井良直、北川拓、井川貴行 、井澤和眞 、菅野貴康 、長谷部直幸
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] がんの化学療法期間中に連続で左室駆出分画(EF) の低下を認めた症例では EF が正常であっても心障害が存在する可能性がある (2019)
  • Author(s): 井上仁喜、菊地麻美、杉山英太郎、長谷部直幸
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] 睡眠時無呼吸症候群と高血圧・虚血性心疾患・大動脈解離・洞不全症候群との関連および CPAP の治療効果についての検討 (2019)
  • Author(s): 柏木雄介、堀田大介、長谷部直幸、菊池健次郎
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] 無症状で発見された巨大右冠動脈-左室瘻の 1 例 (2019)
  • Author(s): 貴田岡享、小川裕二、鈴木孝英、浅野目晃、平井俊浩、柴山佳一郎、秋田滉一、長谷部直幸
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] 当院における心不全入院患者についての検討 (2019)
  • Author(s): 西浦猛、酒井博司、八巻多、岩田周耕、豊嶋更紗、徳野翔太、砂田大貴、長谷部直幸
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] 心不全発症に抗アンドロゲン剤の関与が強く疑われた一症例 (2019)
  • Author(s): 名取俊介、野呂忠孝、長谷部直幸
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] 冠動脈病変を合併した IgG4 関連疾患のマルチモダリティイメージング (2019)
  • Author(s): 細口翔平、坂本央、蓑島暁帆、山田一紀、伊達歩、竹内利治、赤坂和美、武井英博、長谷部直幸
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] 担がん患者に対する心臓リハビリテーションの4施行例 (2019)
  • Author(s): 早坂太希、伊達歩、久木田新、豊嶋更紗、本谷光咲子、木谷祐也、蓑島暁帆、竹内利治、三田村信雄、呂隆徳、大田哲生、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 先行するFEC両方がトラスツズマブによる心筋障害に及ぼす影響について (2019)
  • Author(s): 杉山英太郎、井上仁喜、菊地麻美、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] がん関連血栓症に寄る脳梗塞の臨床的特徴 The clinical features of patients with cerebral infarction due to cancerassociated thrombosis (2019)
  • Author(s): 澤田潤、鹿野耕平、齋藤司、片山隆行、和田始、安栄良悟、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 悪性腫瘍を有する患者の深部静脈血栓症の診断におけるD-dimerの意義 (2019)
  • Author(s): 井上仁喜、菊地麻美、杉山英太郎、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 共有データベースを利用した腫瘍循環器センターにおける多職種連携とデータ管理 (2019)
  • Author(s): 井上仁喜、菊地麻美、杉山英太郎、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 会長講演「腫瘍循環器的患者診察のススメ」 (2019)
  • Author(s): 長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
  • Invited
• [Presentation] 高血圧歴のない癌患者における、ベバシズマブの血圧及び心機能への影響 (2019)
  • Author(s): 杉山英太郎、井上仁喜、菊地麻美、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 化学療法による副腎機能低下における Apurinic-apyrimidinice endonuclease 1 の役割―H3K4 トリメチル化の関わり (2019)
  • Author(s): 藤野貴行、佐久間寛史、山田夏生、松田正大、林望美、松木孝樹、中川直樹、木谷祐也、竹内利治、佐藤伸之、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] ホルモン療法によるがん治療中に発症した心不全の 2 症例 (2019)
  • Author(s): 名取俊介、野呂忠孝、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 長期経過観察し得た成人心臓線維腫のマルチモダリティイメージング (2019)
  • Author(s): 黒嶋健起、坂本央、蓑島暁帆、田邊康子、竹内利治、赤坂和美、赤坂伸之、佐藤伸之、武井英博、紙谷寛之
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 悪性腫瘍合併急性冠症候群における患者背景と治療経過の検討 (2019)
  • Author(s): 蓑島暁帆、渡辺栞、黒嶋健起、木谷祐也、伊達歩、坂本央、竹内利治、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 肺扁平上皮癌を合併した心臓血管筋脂肪腫症例の検討 (2019)
  • Author(s): 豊嶋更紗、坂本央、遠藤哲史、蓑島暁帆、田邊康子、竹内利治、赤坂和美、佐藤伸之、川村祐一郎、武井英博、北田正博、紙谷寛之、大崎能伸、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 左室駆出分画の 2 回連続低下は化学療法による心障害の早期指標である (2019)
  • Author(s): 井上仁喜、菊地麻美、杉山英太郎、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 当院における腫瘍循環器外来の取り組み (2019)
  • Author(s): 木谷祐也
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 癌化学療法患者の CV ポートに起因する静脈血栓症の臨床的検討 (2019)
  • Author(s): 杉山英太郎、井上仁喜、菊地麻美、長谷部直幸
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 放射線治療後長期間を経て発症した急性下肢動脈閉塞の 1 例 (2019)
  • Author(s): 明上卓也、加藤瑞季、大津圭介、本間恒章、武藤晴達、藤田雅章、佐藤実、井上仁喜、竹中孝
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] VT stormから救命し得たANCA関連腎炎合併たこつぼ心筋症の一例 (2019)
  • Author(s): 末次令奈、八巻多、徳野翔太、中川敬太、岩田周耕、西浦猛、酒井博司、丸山啓介、中川直樹、藤野貴行、 川村祐一郎、長谷部直幸
  • Organizer: 第49回日本腎臓学会東部学術大会
• [Presentation] 尿蛋白陰性でマルベリー小体を認めたファブリー病姉妹例の腎病理所見の検討 (2019)
  • Author(s): 山田夏生、中川直樹、佐久間寛史、丸山啓介、松木孝樹、藤野貴行、小川弥生、長谷部直幸
  • Organizer: 第49回日本腎臓学会東部学術大会
• [Presentation] Strategy for Antihypertensive Drug Therapy in JSH2019 (2019)
  • Author(s): 長谷部直幸
  • Organizer: 第42回日本高血圧学会総会
  • Invited
• [Presentation] どうする高血圧 ～あなたと考える明日の高血圧診療～ (2019)
  • Author(s): 長谷部直幸
  • Organizer: 第42回日本高血圧学会総会
  • Invited
• [Presentation] White-coat and Masked Hypertension Based on Automated Office Blood Pressure and Office Blood Pressure in a General Population (2019)
  • Author(s): 林望美、中川直樹、佐久間寛史、堀内至、鈴木彩菜、早坂太希、丸山啓介、澤田潤、蓑島暁帆、藤野貴行、竹内利治、赤坂和美、佐藤伸之、長内忍、長谷部直幸
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] A survey of hypertension in chronic hemodialysis patients at the end of 2016 using WADDA system (2019)
  • Author(s): 佐久間寛史、山田夏生、丸山啓介、松木孝樹、中川直樹、藤野貴行、長谷部直幸
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] Study on effect of an association between sleep apnea syndrome and high blood pressure, sinus imperfection syndrome and the CPAP (2019)
  • Author(s): 柏木雄介、堀田大介、長谷部直幸 、菊池健次郎
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] Relationships between management status of clinical/home blood pressure level and anticoagulation therapy in elderly non-valvular atrial fibrillation from ANAFIE registry. (2019)
  • Author(s): 苅尾七臣 、長谷部直幸 、ANAFIE Registry 研究グループ
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] 心肝連関におけるNAFLD fibrosis scoreについて (2019)
  • Author(s): 赤坂和美、河端奈穂子、長谷部直幸、藤井聡
  • Organizer: 第66回日本臨床検査医学会学術集会
• [Presentation] 新規血管周幹細胞は、骨格筋再生に寄与する (2019)
  • Author(s): 鹿野耕平、堀内至、吉田有里、澤田潤、早坂太希、富田唯、竜川貴光、鹿原真樹、丸山啓介、中川直樹、竹原有史、長谷部直幸、川辺淳一
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] Ninjurin1は、NG2陽性シュワン前駆細胞の成熟化を調整することにより末梢神経再生に関わる (2019)
  • Author(s): 富田唯、堀内至、鹿野耕平、吉田有里、竜川貴光、中島恵一、早坂太希、鹿原真樹、中川直樹、竹原有史、長谷部直幸、川辺淳一
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] 周細胞特異的Ninjurin1欠損は、障害血管外膜vasa vasorumの形成異常により血管内膜肥厚の増悪をもたらす (2019)
  • Author(s): 堀内至、蓑島暁帆、鹿原真樹、早坂太希、吉田有里、鹿野耕平、富田唯、丸山啓介、中川直樹、竹原有史、長谷部直幸、川辺淳一
  • Organizer: 第42回日本分子生物学会年会
• [Presentation] EphA7陽性周細胞は、筋ジストロフィーモデルマウスの病態を改善する (2019)
  • Author(s): 鹿野耕平、堀内至、吉田有里、早坂太希、鹿原真樹、富田唯、竜川貴光、松尾梨沙、安田哲、中島恵一、澤田潤、中川直樹、竹原有史、長谷部直幸、川辺淳一
  • Organizer: 第27日本血管生物医学会学術集会(血管代謝週間2019)
• [Presentation] シンポジウム1「合併症からみた生活習慣病上流因子としての肥満症：領域横断的肥満症ＷＧ連携企画①」 (2019)
  • Author(s): 長谷部直幸
  • Organizer: 第40回日本肥満学会
  • Invited
• [Book] 今日の治療指針 2020年版 (2020)
  • Author(s): 福井 次矢他（編）、分担執筆 長谷部直幸
  • Total Pages: 2192
  • Publisher: 医学書院
  • ISBN: 9784260039390
• [Book] 循環器疾患最新の治療2020-2021 (2020)
  • Author(s): 伊藤 浩、山下 武志他（編）、分担執筆 長谷部直幸
  • Total Pages: 500
  • Publisher: 南江堂
  • ISBN: 9784524249763
• [Book] 今日の診断指針 第8版 (2020)
  • Author(s): 永井 良三他（編）、分担執筆 長谷部直幸
  • Total Pages: 2114
  • Publisher: 医学書院
  • ISBN: 9784260038089
• [Book] 循環器症候群 第３版 (2020)
  • Author(s): 小室一成（編）、分担執筆 長谷部直幸
  • Total Pages: 405
  • Publisher: 日本臨床社
• [Book] 腫瘍循環器診療ハンドブック (2020)
  • Author(s): 小室 一成、日本腫瘍循環器学会編集委員会 分担執筆 長谷部直幸
  • Total Pages: 240
  • Publisher: メジカルビュー社
  • ISBN: 9784758319669