| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Although past studies have suggested the involvement of estrogen in the development and progression of atherosclerosis, the detailed pathophysiological and molecular biological mechanisms remain unresolved. In this study, we aimed to elucidate the response mechanism after vascular injury in terms of "vascular browning. We elucidated the significance of beiging using adipoq-Cre PRDM16 flox mice and identified an anti-inflammatory secreted factor, neureglin4, derived from beiging PVAT by single-cell analysis. These results indicate that beiging of PVAT following vascular injury leads to the resolution of vascular inflammation and suppresses pathological vascular remodeling.
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