A New Approach to Postmenopausal Atherosclerotic Disease Based on "Vascular Beiging"
| Project/Area Number |
18K08096
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Ueda Kazutaka 東京大学, 医学部附属病院, 助教 (60375798)
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 動脈硬化 / 性ホルモン / 脂肪褐色化 / エストロゲン / エストロゲン受容体 / 肥満 / 視床下部 / 血管リモデリング / 炎症 / 血管周囲脂肪 / 褐色化 / 血管傷害 / 炎症性サイトカイン / マクロファージ |
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| Outline of Final Research Achievements |
Although past studies have suggested the involvement of estrogen in the development and progression of atherosclerosis, the detailed pathophysiological and molecular biological mechanisms remain unresolved. In this study, we aimed to elucidate the response mechanism after vascular injury in terms of "vascular browning. We elucidated the significance of beiging using adipoq-Cre PRDM16 flox mice and identified an anti-inflammatory secreted factor, neureglin4, derived from beiging PVAT by single-cell analysis. These results indicate that beiging of PVAT following vascular injury leads to the resolution of vascular inflammation and suppresses pathological vascular remodeling.
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| Academic Significance and Societal Importance of the Research Achievements |
傷害血管で褐色脂肪に特徴的な遺伝子発現が増加する「血管の褐色化」はこれまでにほとんど報告のない新しい概念である。本研究により、血管褐色化の制御が動脈硬化性疾患の新たな治療ターゲットとして見出される可能性がある。
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Report
(5 results)
Research Products
(15 results)
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[Journal Article] Overview of the 83<sup>rd</sup> Annual Scientific Meeting of the Japanese Circulation Society ― Renaissance of Cardiology for the Creation of Future Medicine ―2019
Author(s)
Akazawa H, Toko H, Harada M, Ueda K, Kodera S, Kiyosue A, Fujiu K, Hatano M, Daimon M, Ando J, Takimoto E, Morita H, Komuro I
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Journal Title
Circulation Journal
Volume: 83
Issue: 9
Pages: 1829-1835
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2019-08-23
Related Report
Peer Reviewed / Open Access
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