Scientific Research for the Development of Novel Therapeutics in Marfan Syndrome Targeting Endothelial Cells-derived Oxidative Stress

• Project/Area Number: 18K08097
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Akazawa Hiroshi 東京大学, 医学部附属病院, 講師 (20396683)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2019: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 分子血管学 / 大動脈瘤 / 酸化ストレス / 血管内皮 / メカニカルストレス

Outline of Final Research Achievements

We demonstrated that aberrant activation of mechanosensitive signaling in vascular endothelial cells triggered endothelial activation of xanthine oxidoreductase (XOR) and generation of reactive oxygen species (ROS), leading to progression of aneurysm formation in ascending aorta of Marfan syndrome.
There is currently no effective medical treatment, but our study highlights a drug repositioning approach using a uric acid lowering drug febuxostat as a potential therapy for Marfan syndrome.

Academic Significance and Societal Importance of the Research Achievements

マルファン症候群はFBN1の遺伝子異常により全身の結合組織の構造・機能破綻を来す常染色体優性の希少難治性疾患である。MFSの遺伝子変異による疾患発症の分子機序はいまだに不明な点が多く残されていたが、本研究により血管内皮におけるxanthine oxidoreductase由来の酸化ストレスがマルファン症候群における大動脈瘤の病態形成に重要な役割を果たすことが明らかとなった。Xanthine oxidoreductase阻害薬であるfebuxostatの新規治療法開発へと応用されることが期待される。

Research Products

• [Journal Article] Axitinib Induces and Aggravates Hypertension Regardless of Prior Treatment With Tyrosine Kinase Inhibitors (2021)
  • Author(s): Kadowaki Hiroshi、Ishida Junichi、Akazawa Hiroshi、Yagi Hiroki、Saga-Kamo Akiko、Umei Masahiko、Matsuoka Ryo、Liu Qing、Matsunaga Hiroshi、Maki Hisataka、Sato Yusuke、Kume Haruki、Komuro Issei
  • Journal Title: Circulation Reports Volume: 3 Issue: 4 Pages: 234-240
  • DOI: 10.1253/circrep.CR-21-0008
  • NAID: 130008023456
  • ISSN: 2434-0790
  • Year and Date: 2021-04-09
  • Peer Reviewed / Open Access
• [Journal Article] Factors associated with left ventricular reverse remodelling after percutaneous coronary intervention in patients with left ventricular systolic dysfunction (2021)
  • Author(s): Adachi Y、Kiyosue A、Ando J、Kawahara T、Kodera S、Minatsuki S、Kikuchi H、Inaba T、Kiriyama H、Hirose K、Shinohara H、Saito A、Fujiwara T、Hara H、Ueda K、Sakakura K、Hatano M、Harada M、Takimoto E、Akazawa H、Morita H、Momomura S、Fujita H、Komuro I
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 239-239
  • DOI: 10.1038/s41598-020-80491-y
  • Peer Reviewed / Open Access
• [Journal Article] A Fatal Case of Myocarditis Following Myositis Induced by Pembrolizumab Treatment for Metastatic Upper Urinary Tract Urothelial Carcinoma (2020)
  • Author(s): Matsui Hotaka、Kawai Taketo、Sato Yusuke、Ishida Junichi、Kadowaki Hiroshi、Akiyama Yoshiyuki、Yamada Yuta、Nakamura Masaki、Yamada Daisuke、Akazawa Hiroshi、Suzuki Motofumi、Komuro Issei、Kume Haruki
  • Journal Title: International Heart Journal Volume: 61 Issue: 5 Pages: 1070-1074
  • DOI: 10.1536/ihj.20-162
  • NAID: 130007911362
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2020-09-29
  • Peer Reviewed
• [Journal Article] Cancer Therapeutics-Related Cardiac Dysfunction ― Insights From Bench and Bedside of Onco-Cardiology ― (2020)
  • Author(s): Kadowaki Hiroshi、Akazawa Hiroshi、Ishida Junichi、Komuro Issei
  • Journal Title: Circulation Journal Volume: 84 Issue: 9 Pages: 1446-1453
  • DOI: 10.1253/circj.CJ-20-0467
  • NAID: 130007890790
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-08-25
  • Peer Reviewed / Open Access
• [Journal Article] Diagnosing Heart Failure from Chest X-Ray Images Using Deep Learning (2020)
  • Author(s): Matsumoto Takuya、Kodera Satoshi、Shinohara Hiroki、Ieki Hirotaka、Yamaguchi Toshihiro、Higashikuni Yasutomi、Kiyosue Arihiro、Ito Kaoru、Ando Jiro、Takimoto Eiki、Akazawa Hiroshi、Morita Hiroyuki、Komuro Issei
  • Journal Title: International Heart Journal Volume: 61 Issue: 4 Pages: 781-786
  • DOI: 10.1536/ihj.19-714
  • NAID: 130007882144
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2020-07-30
  • Peer Reviewed
• [Journal Article] Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease (2020)
  • Author(s): Matsunaga Hiroshi, ... Ogishima Soichi et al.
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 13 Issue: 3
  • DOI: 10.1161/circgen.119.002670
  • Peer Reviewed / Open Access
• [Journal Article] The dawning of the digital era in the management of hypertension (2020)
  • Author(s): Matsuoka Ryo、Akazawa Hiroshi、Kodera Satoshi、Komuro Issei
  • Journal Title: Hypertension Research Volume: 43 Issue: 11 Pages: 1135-1140
  • DOI: 10.1038/s41440-020-0506-1
  • Peer Reviewed
• [Journal Article] Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease (2020)
  • Author(s): 2.Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, Ieki H, Ozaki K, Onouchi Y, Takahashi A, Nomura S, Morita H, Akazawa H, Kim C, Seo JS, Higasa K, Iwasaki M, Yamaji T, et al.
  • Journal Title: Nature Genetics Volume: 52 Issue: 11 Pages: 1169-1177
  • DOI: 10.1038/s41588-020-0705-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Inhibition of transforming growth factor-β signaling in myeloid cells ameliorates aortic aneurysmal formation in Marfan syndrome (2020)
  • Author(s): Hara Hironori、Maemura Sonoko、Fujiwara Takayuki、Takeda Norifumi、Ishii Satoshi、Yagi Hiroki、Suzuki Takaaki、Harada Mutsuo、Toko Haruhiro、Kanaya Tsubasa、Ijichi Hideaki、Moses Harold L.、Takimoto Eiki、Morita Hiroyuki、Akazawa Hiroshi、Komuro Issei
  • Journal Title: PLOS ONE Volume: 15 Issue: 11 Pages: e0239908-e0239908
  • DOI: 10.1371/journal.pone.0239908
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardio-Oncology in Japan (2020)
  • Author(s): Oka Toru、Akazawa Hiroshi、Sase Kazuhiro、Hatake Kiyohiko、Komuro Issei
  • Journal Title: JACC: CardioOncology Volume: 2 Issue: 5 Pages: 815-818
  • DOI: 10.1016/j.jaccao.2020.10.014
  • Peer Reviewed / Open Access
• [Journal Article] Overview of the 83^rd Annual Scientific Meeting of the Japanese Circulation Society ― Renaissance of Cardiology for the Creation of Future Medicine ― (2019)
  • Author(s): Akazawa H, Toko H, Harada M, Ueda K, Kodera S, Kiyosue A, Fujiu K, Hatano M, Daimon M, Ando J, Takimoto E, Morita H, Komuro I
  • Journal Title: Circulation Journal Volume: 83 Issue: 9 Pages: 1829-1835
  • DOI: 10.1253/circj.CJ-19-0587
  • NAID: 130007695023
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-08-23
  • Peer Reviewed / Open Access
• [Journal Article] Pressure Overload Impairs Cardiac Function in Long-Chain Fatty Acid Transporter CD36-Knockout Mice (2019)
  • Author(s): Nakatani Kazuhiro、Masuda Daisaku、Kobayashi Takuya、Sairyo Masami、Zhu Yinghong、Okada Takeshi、Naito Atsuhiko T.、Ohama Tohru、Koseki Masahiro、Oka Toru、Akazawa Hiroshi、Nishida Makoto、Komuro Issei、Sakata Yasushi、Yamashita Shizuya
  • Journal Title: International Heart Journal Volume: 60 Issue: 1 Pages: 159-167
  • DOI: 10.1536/ihj.18-114
  • NAID: 130007557124
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2019-01-31
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Onco-cardiology in the field of hematology (2019)
  • Author(s): Akazawa H
  • Journal Title: Rinsho Ketsueki Volume: 60 Issue: 9 Pages: 1372-1377
  • DOI: 10.11406/rinketsu.60.1372
  • NAID: 130007724656
  • ISSN: 0485-1439, 1882-0824
  • Peer Reviewed
• [Journal Article] OCT-Based Management of Nilotinib-Associated CAD in a Patient With Chronic Myeloid Leukemia. (2019)
  • Author(s): 112. Kiriyama H, Ishida J, Kadowaki H, Iwasa T, Kiyosue A, Kodera S, Ando J, Akazawa H, Komuro I
  • Journal Title: JACC CardioOncology Volume: 1 Issue: 2 Pages: 318-321
  • DOI: 10.1016/j.jaccao.2019.09.006
  • Peer Reviewed
• [Journal Article] High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload (2019)
  • Author(s): Satoh M、Nomura S、Harada M、Yamaguchi T、Ko T、Sumida T、Toko H、Naito AT.、Takeda N、Tobita T、Fujita T、Ito M、Fujita K、Ishizuka M、Kariya T、Akazawa H、Kobayashi Y、Morita H、Takimoto E、Aburatani H、Komuro I
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 128 Pages: 77-89
  • DOI: 10.1016/j.yjmcc.2018.12.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Novel Bioabsorbable Sheet That Delivers NF-κB Decoy Oligonucleotide Restrains Abdominal Aortic Aneurysm Development in Rats (2018)
  • Author(s): Akimoto Shouta、Suzuki Jun-ichi、Aoyama Norio、Ikeuchi Ryota、Watanabe Hajime、Tsujimoto Hiroyuki、Wakayama Kouji、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei
  • Journal Title: International Heart Journal Volume: 59 Issue: 5 Pages: 1134-1141
  • DOI: 10.1536/ihj.17-632
  • NAID: 130007490504
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-09-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Periodontitis and Diabetes Mellitus (2018)
  • Author(s): Akazawa Hiroshi
  • Journal Title: International Heart Journal Volume: 59 Issue: 4 Pages: 680-682
  • DOI: 10.1536/ihj.18-410
  • NAID: 130007428119
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2018-07-31
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Japanese Cardiovascular Disease Patients with Diabetes Mellitus Suffer Increased Tooth Loss in Comparison to Those without Diabetes Mellitus -A Cross-sectional Study (2018)
  • Author(s): Aoyama Norio、Suzuki Jun-ichi、Kobayashi Naho、Hanatani Tomoya、Ashigaki Norihiko、Yoshida Asuka、Shiheido Yuka、Sato Hiroki、Kumagai Hidetoshi、Ikeda Yuichi、Akazawa Hiroshi、Komuro Issei、Minabe Masato、Izumi Yuichi、Isobe Mitsuaki
  • Journal Title: Internal Medicine Volume: 57 Issue: 6 Pages: 777-782
  • DOI: 10.2169/internalmedicine.9578-17
  • NAID: 130006507416
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Distinct variants affecting differential splicing of TGFBR1 exon 5 cause either Loeys?Dietz syndrome or multiple self-healing squamous epithelioma (2018)
  • Author(s): Fujiwara Takayuki、Takeda Norifumi、Hara Hironori、Morita Hiroyuki、Kishihara Jun、Inuzuka Ryo、Yagi Hiroki、Maemura Sonoko、Toko Haruhiro、Harada Mutsuo、Ikeda Yuichi、Kumagai Hidetoshi、Nomura Seitaro、Takimoto Eiki、Akazawa Hiroshi、Ako Junya、Komuro Issei
  • Journal Title: European Journal of Human Genetics Volume: 26 Issue: 8 Pages: 1151-1158
  • DOI: 10.1038/s41431-018-0127-1
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Discovery of a Small Molecule to Increase Cardiomyocytes and Protect the Heart After Ischemic Injury (2018)
  • Author(s): Hara H, Takeda N, Kondo M, Kubota M, Saito T, Maruyama J, Fujiwara T, Maemura S, Ito M, Naito AT, Harada M, Toko H, Nomura S, Kumagai H, Ikeda Y, Ueno H, Takimoto E, Akazawa H, Morita H, Aburatani H, Hata Y, Uchiyama M, Komuro I.
  • Journal Title: JACC: Basic to Translational Science Volume: 3 Issue: 5 Pages: 639-653
  • DOI: 10.1016/j.jacbts.2018.07.005
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure. (2018)
  • Author(s): Nomura S, Satoh M, Fujita T, Higo T, Sumida T, Ko T, Yamaguchi T, Tobita T, Naito AT, Ito M, Fujita K, Harada M, Toko H, Kobayashi Y, Ito K, Takimoto E, Akazawa H, Morita H, Aburatani H, Komuro I.
  • Journal Title: Nat Commun. Volume: 9 Issue: 1 Pages: 4435-4435
  • DOI: 10.1038/s41467-018-06639-7
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Activated β-catenin in Foxp3+ regulatory T cells links inflammatory environments to autoimmunity (2018)
  • Author(s): Sumida Tomokazu、Lincoln Matthew R.、Ukeje Chinonso M.、Rodriguez Donald M.、Akazawa Hiroshi、Noda Tetsuo、Naito Atsuhiko T.、Komuro Issei、Dominguez-Villar Margarita、Hafler David A.
  • Journal Title: Nature Immunology Volume: 19 Issue: 12 Pages: 1391-1402
  • DOI: 10.1038/s41590-018-0236-6
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of Pathogenic FBN1 Variant Types on the Progression of Aortic Disease in Patients With Marfan Syndrome (2018)
  • Author(s): Takeda N, Inuzuka R, Maemura S, Morita H, Nawata K, Fujita D, Taniguchi Y, Yamauchi H, Yagi H, Kato M, Nishimura H, Hirata Y, Ikeda Y, Kumagai H, Amiya E, Hara H, Fujiwara T, Akazawa H, Suzuki JI, Imai Y, Nagai R, Takamoto S, Hirata Y, Ono M, Komuro I.
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 11 Issue: 6
  • DOI: 10.1161/circgen.117.002058
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MicroRNAs as biomarkers for cardiac sarcoidosis: No matter how small (2018)
  • Author(s): Umei Masahiko、Akazawa Hiroshi
  • Journal Title: Journal of Cardiology Volume: 72 Issue: 6 Pages: 449-451
  • DOI: 10.1016/j.jjcc.2018.08.001
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Late-onset hypertension was associated with progression-free survival in cancer patients with an angiogenesis inhibitor sunitinib. (2021)
  • Author(s): Hiroshi Kadowaki, Hiroshi Akazawa, Junichi Ishida, Issei Komuro
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Deep Learning-based Approach for Screening Atrial Septal Defect on Chest Radiographs. (2021)
  • Author(s): Ryo Matsuoka, Hiroshi Akazawa, Satoshi Kodera, Katsura Soma, Hiroki Yagi, Masahiko Umei, Hiroshi Kadowaki, Junichi Ishida, Hiroki Shinohara, Susumu Katsushika, Hirotaka Ieki, Toshihiro Yamaguchi, Yasutomi Higashikuni, Katshito Fujiu, Kaoru Ito, Atsushi Yao, Issei Komuro
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Protective action of the microbial metabolite butyrate against cardiomyocyte hypertrophy. (2020)
  • Author(s): Masahiko Umei, Hiroshi Akazawa, Akiko Saga-Kamo, Hiroki Yagi, Qing Liu, Hiroshi Kadowaki, Ryo Matsuoka, Hiroshi Matsunaga, Issei Komuro
  • Organizer: ESC Congress 2020 The Digital Experience
  • Int'l Joint Research
• [Presentation] Xanthine oxidoreductase in adventitial macrophages amplifies reactive oxygen generation and exacerbates aortic aneurysm development in a mouse model of Marfan syndrome. (2020)
  • Author(s): Hiroki Yagi, Hiroshi Akazawa, Qing Liu, Norifumi Takeda, Issei Komuro
  • Organizer: GenTAC Aortic Summit 2020
  • Int'l Joint Research
• [Presentation] The evaluation for molecular mechanisms of short-chain fatty acid on protective effect for heart failure. (2020)
  • Author(s): Masahiro Umei, Hiroshi Akazawa, Akiko Saga-Kamo, Hiroki Yagi, Qing Liu, Hiroshi Kadowaki, Ryo Matsuoka, Hiroshi Matsunaga, Issei Komuro
  • Organizer: 第24回腸内細菌学会学術集会
• [Presentation] がん関連血栓塞栓症を識る、診る、治す (2020)
  • Author(s): 赤澤 宏
  • Organizer: 第21回日本検査血液学会学術集会
  • Invited
• [Presentation] がん治療関連心機能障害の診療とリハビリテーション (2020)
  • Author(s): 赤澤 宏
  • Organizer: 第26回日本心臓リハビリテーション学会学術集会
  • Invited
• [Presentation] Xanthine oxidoreductase in adventitial macrophages exacerbates aortic aneurysm progression by amplifying ROS generation in a mouse model of Marfan syndrome. (2020)
  • Author(s): Hiroki Yagi, Hiroshi Akazawa, Qing Liu, Akiko Saga-Kamo, Chizuru Yabumoto, Masahiko Umei, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Norifumi Takeda, Issei Komuro
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] Oral administration of Euglena gracilis Z alleviates cardiac dysfunction and constipation in a mouse model of isoproterenol-induced heart failure. (2020)
  • Author(s): Masahiko Umei, Hiroshi Akazawa, Ayaka Nakashima, Kosuke Yasuda, Akiko Saga-Kamo, Hiroki Yagi, Qing Liu, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Issei Komuro
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] Genome-wide association study for atrial fibrillation identifies 26 novel loci and reveals the genetic correlation with comorbid disorders. (2020)
  • Author(s): Hiroshi Matsunaga, Kaoru Ito, Satoshi Koyama, Seitaro Nomura, Hirotaka Ieki, Kouichi Ozaki, Yoshihiro Onouchi, Hiroshi Akazawa, Issei Komuro
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] 免疫チェックポイント阻害剤による心血管合併症とその対策 (2020)
  • Author(s): 赤澤 宏
  • Organizer: 第3回日本腫瘍循環器学会学術集会
  • Invited
• [Presentation] 腫瘍循環器の視点で考える免疫チェックポイント阻害薬と抗VEGF阻害薬の併用療法 (2020)
  • Author(s): 赤澤 宏
  • Organizer: 第3回日本腫瘍循環器学会学術集会
  • Invited
• [Presentation] チロシンキナーゼ阻害薬スニチニブによる心機能障害の診断の現状 (2020)
  • Author(s): 佐藤 恒、門脇 裕、石田純一、赤澤 宏、牧 尚孝、小室一成
  • Organizer: 第3回日本腫瘍循環器学会学術集会
• [Presentation] 機械的循環補助により救命できたがん治療関連心機能障害による重症心不全の２症例 (2020)
  • Author(s): 進藤彰人、石田純一、安藤政彦、嶋田正吾、木下 修、山内治雄、小野 稔、網谷英介、波多野 将、門脇 裕、辻 正樹、赤澤 宏、小室一成
  • Organizer: 第3回日本腫瘍循環器学会学術集会
• [Presentation] Protective action of the gut microbial metabolite butyrate against cardiac hypertrophy. (2020)
  • Author(s): Masahiko Umei, Hiroshi Akazawa, Akiko Saga-Kamo, Hiroki Yagi, Qing Liu, Hiroshi Kadowaki, Ryo Matsuoka, Hiroshi Matsunaga, Seitaro Nomura, Issei Komuro
  • Organizer: The 4th JCS Council Forum on Basic CardioVascular Research
• [Presentation] がん治療関連心筋障害の病態と診断 (2020)
  • Author(s): 赤澤 宏
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] がん治療関連心筋障害 (2020)
  • Author(s): 赤澤 宏
  • Organizer: 第24回日本心不全学会学術集会
  • Invited
• [Presentation] 一時的な機械的循環補助により救命できた薬剤性心筋症による重症心不全の一例 (2020)
  • Author(s): 久米里実、石田純一、進藤彰人、網谷英介、波多野 将、門脇 裕、赤澤 宏、嶋田正吾、小野 稔、小室一成
  • Organizer: 第258回日本循環器学会関東甲信越地方会
• [Presentation] Before ARNI, After ARNI、心不全治療を変えるARNIに実力とは？ (2020)
  • Author(s): 赤澤 宏
  • Organizer: 第85回日本循環器学会学術集会
  • Invited
• [Presentation] マルファン症候群に対する分子標的治療への挑戦 (2020)
  • Author(s): 赤澤 宏
  • Organizer: 第49回日本心脈管作動物質学会
  • Invited
• [Presentation] Xanthine oxidoreductase in adventitial macrophages amplifies reactive oxygen generation and aggravates aortic aneurysm progression in a mouse model of Marfan syndrome (2019)
  • Author(s): Yagi H, Akazawa H, Liu Q, Saga-Kamo A, Yabumoto C, Umei M, Matsunaga H, Kadowaki H, Matsuoka R, Takeda N, Komuro I
  • Organizer: ・ American Heart Association Scientific Sessions 2019
  • Int'l Joint Research
• [Presentation] Onco-Cardiologyの基礎研究と臨床応用 (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第108回日本病理学会総会
  • Invited
• [Presentation] がん治療による心血管合併症の診断とマネジメント (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第92回日本超音波医学会学術集会
  • Invited
• [Presentation] がん関連血栓症の治療にもたらしたパラダイムシフト (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第4回国際心血管薬物療法学会日本部会年次学術集会
  • Invited
• [Presentation] 乳がん症例におけるがん治療関連心血管合併症に対する循環器内科との連携診療体制の検討 (2019)
  • Author(s): 小西孝明孝明、石田純一、田辺真彦、林香菜子、大矢真理子、尾辻和尊、佐藤綾花、丹羽隆善、西岡琴江、赤澤 宏、小室一成、瀬戸泰之
  • Organizer: 第27回日本乳癌学会学術総会
• [Presentation] 急性・慢性心不全ガイドライン改定のポイント (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第29回日本心臓核医学会総会・学術集会
  • Invited
• [Presentation] がん関連血栓症における抗凝固療法のパラダイムシフト (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第2回日本腫瘍循環器学会学術集会
  • Invited
• [Presentation] 免疫チェックポイント阻害薬関連心筋炎の自験例からの学びと次なる診療への応用 (2019)
  • Author(s): 門脇 裕、石田純一、赤澤 宏、牧 尚孝。成田晃一、清末有宏、小室一成
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 進行肝細胞癌症例におけるレンバチニブ関連高血圧症の臨床的特徴の検討 (2019)
  • Author(s): 石田純一、赤澤 宏、門脇 裕、牧 尚孝、小室一成
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] 乳がん薬物治療関連心機能障害/心不全の管理のための診療アルゴリズムの有用性の検討 (2019)
  • Author(s): 石田純一、赤澤 宏、門脇 裕、牧 尚孝、小室一成
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] ベバシズマブによる肺血管内皮障害が原因と考えられた肺動脈性肺高血圧症の１例 (2019)
  • Author(s): 牧 尚孝、石田純一、門脇 裕、赤澤 宏、志賀太郎、小室一成
  • Organizer: 第2回日本腫瘍循環器学会学術集会
• [Presentation] がん治療関連心機能障害～病態と診断・治療の最新知見 (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第23回日本心不全学会学術集会
  • Invited
• [Presentation] 診療科連携と多職種連携による腫瘍循環器チーム医療 (2019)
  • Author(s): 石田純一、赤澤 宏、門脇 裕、牧 尚孝、小室一成
  • Organizer: 第23回日本心不全学会学術集会
  • Invited
• [Presentation] 抗がん剤による脈管障害とその対応 (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第60回日本脈管学会総会
  • Invited
• [Presentation] 造血器領域のOnco-Cardiology (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第81回日本血液学会学術集会
  • Invited
• [Presentation] みらい医療の実現へ向けて (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第1回Digital Hypertension Conference
  • Invited
• [Presentation] 切除不能肝細胞癌症例におけるレンバチニブ投与に伴う高血圧症の臨床的特徴の検討 (2019)
  • Author(s): 石田純一、赤澤 宏、門脇 裕、牧 尚孝、小室一成
  • Organizer: 第42回日本高血圧学会総会
• [Presentation] 腫瘍循環器学の進歩と心不全 (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第40回日本臨床薬理学会学術総会
  • Invited
• [Presentation] 腫瘍循環器学が拓く新しい医学と医療 (2019)
  • Author(s): 赤澤 宏
  • Organizer: 第41回心筋生検研究会学術集会
  • Invited
• [Presentation] がん関連血栓症の新たな治療戦略 (2019)
  • Author(s): 赤澤宏
  • Organizer: 第251回日本循環器学会関東甲信越地方会
• [Presentation] 腫瘍循環器学が目指すこれからの医学と医療 (2019)
  • Author(s): 赤澤宏
  • Organizer: 第10回日本安全性薬理研究会年会
  • Invited
• [Presentation] 腫瘍循環器学～がん診療のアンメットニーズに応えるために (2019)
  • Author(s): 赤澤宏
  • Organizer: 第38回日本画像医学会
  • Invited
• [Presentation] The RENAISSANCE of Basic CardioVascular Research (2019)
  • Author(s): 赤澤宏
  • Organizer: 第83回日本循環器学会学術集会
  • Invited
• [Presentation] がん化学療法による心血管合併症 (2019)
  • Author(s): 赤澤宏
  • Organizer: 第83回日本循環器学会学術集会
  • Invited
• [Presentation] Endothelial ROS Generation Underlies the Pathogenesis of Thoracic Aortic Aneurysm in Marfan Syndrome (2019)
  • Author(s): Hiroshi Akazawa
  • Organizer: 第83回日本循環器学会学術集会
  • Invited
• [Presentation] Abnormal mechanosensing and activation of xanthine oxidoreductase in vascular endothelial cells mediate aortic aneurysm progression in Marfan syndrome (2019)
  • Author(s): Hiroki Yagi, Hiroshi Akazawa, Qing Liu, Atsumasa Kurozumi, Akiko Saga-Kamo, Masahiko Umei, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Norifumi Takeda, Issei Komuro
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Impaired barrier function of gut epithelium in a mouse model of heart failure (2019)
  • Author(s): Akiko Saga-Kamo, Hiroshi Akazawa, Masahiko Umei, Hiroki Yagi, Qing Liu, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Issei Komuro
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Androgen, but not estrogen, contributes to sex difference in aortic aneurysm formation in Marfan syndrome (2019)
  • Author(s): Qing Liu, Hiroshi Akazawa, Hiroki Yagi, Yusuke Adachi, Akiko Saga-Kamo, Masahiko Umei, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Kazutaka Ueda, Norifumi Takeda, Issei Komuro
  • Organizer: 第83回日本循環器学会学術集会
• [Presentation] Activation of xanthine oxidoreductase in vascular endothelial cells mediates aortic aneurysm formation in Marfan syndrome (2018)
  • Author(s): Hiroki Yagi, Hiroshi Akazawa, Qing Liu, Atsumasa Kurosumi, Norifumi Takeda, Issei Komuro
  • Organizer: 10th International Research Symposium on Marfan Syndrome and Related Disorders
  • Int'l Joint Research
• [Presentation] Cardio-Oncology: Japanese Experiences (2018)
  • Author(s): Hiroshi Akazawa, Junichi Ishida, Issei Komuro
  • Organizer: Asian Pacific Society of Cardiology Congress 2018
  • Int'l Joint Research
• [Presentation] How Can We Use Genetics to Predict Cardiac Toxicity? (2018)
  • Author(s): Hiroshi Akazawa, Junichi Ishida, Issei Komuro
  • Organizer: Asian Pacific Society of Cardiology Congress 2018
  • Int'l Joint Research
• [Presentation] Onco-Cardiology国内外の現状と課題 (2018)
  • Author(s): 赤澤宏
  • Organizer: The 23rd Annual Scientific Meeting of the International Society of Cardiovascular Pharmacotherapy
  • Int'l Joint Research
• [Presentation] Cardio-Oncologyの基礎研究 -分子細胞レベルからみたCTCRDの病態生理 (2018)
  • Author(s): 赤澤宏
  • Organizer: 第66回日本心臓病学会学術集会
  • Invited
• [Presentation] Cardio-Oncologyにおける抗がん剤心毒性への対応 (2018)
  • Author(s): 赤澤宏
  • Organizer: 第8回レギュラトリーサイエンス学会学術大会
  • Invited
• [Presentation] RA系とがんとのあらたな接点 (2018)
  • Author(s): 赤澤宏
  • Organizer: 第41回日本高血圧学会総会
  • Invited
• [Presentation] 血管新生阻害薬による高血圧症の発症機序とその予防・管理 (2018)
  • Author(s): 石田純一、赤澤宏、門脇裕、小室一成,
  • Organizer: 第41回日本高血圧学会総会
• [Presentation] Onco-Cardiology: Exploring a New Frontier with Basic CardioVascular Research (2018)
  • Author(s): Hiroshi Akazawa
  • Organizer: 第2回日本循環器学会基礎研究フォーラム
• [Presentation] Molecular basis for the sex difference in aortic aneurysm formation in Marfan syndrome (2018)
  • Author(s): Qing Liu, Hiroshi Akazawa, Hiroki Yagi, Yusuke Adachi, Akiko Saga-Kamo, Masahiko Umei, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Kasutaka Ueda, Norifumi Takeda, Issei Komuro
  • Organizer: 第2回日本循環器学会基礎研究フォーラム
• [Presentation] The alterations of gut epithelial barrier function in a mouse model of heart (2018)
  • Author(s): Akiko Saga-Kamo, Hiroshi Akazawa, Masahiko Umei, Hiroki Yagi, Qing Liu, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Issei Komuro
  • Organizer: 第2回日本循環器学会基礎研究フォーラム
• [Presentation] 腫瘍循環器学の新たな展開～がん患者を心合併症から守るために (2018)
  • Author(s): 赤澤宏
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] Compromised function of gut epithelial barrier in a mouse model of heart (2018)
  • Author(s): Akiko Saga-Kamo, Hiroshi Akazawa, Masahiko Umei, Hiroki Yagi, Qing Liu, Hiroshi Matsunaga, Hiroshi Kadowaki, Ryo Matsuoka, Issei Komuro
  • Organizer: 第22回日本心不全学会学術集会
• [Presentation] 遺伝性大動脈瘤に対する分子標的治療への挑戦 (2018)
  • Author(s): 赤澤宏
  • Organizer: 第59回日本脈管学会脈管学会総会
  • Invited
• [Presentation] Integrated Approach to Early Detection of Oncology Drug-Induced Cardiotoxicity, (2018)
  • Author(s): Hiroshi Akazawa
  • Organizer: 7th DIA Cardiac Safety Workshop in Japan
  • Invited
• [Presentation] 進行腎細胞癌におけるアキシチニブによる高血圧発症と降圧治療への影響 (2018)
  • Author(s): 門脇裕、石田純一、赤澤宏、牧尚孝、佐藤悠佑、久米春樹、小室一成,
  • Organizer: 第1回日本腫瘍循環器学会学術集会
• [Presentation] 血管新生阻害薬使用症例に対する多職種・多診療科による診療体制 (2018)
  • Author(s): 石田純一、門脇裕、赤澤宏、牧尚孝、吉田俊太郎、小池和彦、小室一成
  • Organizer: 第1回日本腫瘍循環器学会学術集会
• [Presentation] チロシンキナーゼ阻害薬による重篤合併症である冠動脈内血栓症をOCTで診断しえた66歳男性 (2018)
  • Author(s): 桐山皓行、岩佐健史、篠原宏樹、齋藤暁人、皆月隼、菊池宏信、石田純一、清末有宏、小寺聡、安東治郎、赤澤宏、小室一成
  • Organizer: 第1回日本腫瘍循環器学会学術集会
• [Presentation] 乳がん症例におけるがん治療関連心血管合併症に対する循環器内科との連携診療体制について (2018)
  • Author(s): 内山美沙、石田純一、赤澤宏、門脇裕、牧尚孝、大矢真里子、小西孝明、尾辻和尊、西岡琴江、田辺真彦、小室一成
  • Organizer: 第1回日本腫瘍循環器学会学術集会
• [Presentation] 腫瘍循環器学（Onco-Cardiology）～がんと心血管代謝との新たな接点 (2018)
  • Author(s): 赤澤宏
  • Organizer: CVMW2018心血管代謝週間