Study of sugar chains binding to BNP precursors; 1. Structure analysis, 2. Molecular mechanism, 3. relationship with heart failure condition
| Project/Area Number |
18K08103
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中川 靖章 京都大学, 医学研究科, 助教 (70452357)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 心不全 / BNP / proBNP / 糖鎖修飾 / 分子型 / 精製 / ゲル濾過 / 質量分析装置 / 糖鎖構造 / 糖鎖 / プロセシング |
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| Outline of Final Research Achievements |
The current assay for BNP system cross-reacts precursor proBNP, indicating that BNP means proBNP + BNP (= total BNP). The applicant created a new assay system for the proBNP and total BNP, which enabled the measurement of the proBNP / total BNP ratio and showed that this ratio was higher in severe chronic heart failure patients. When we examined the proBNP / total BNP ratio in acute heart failure, we found the proBNP / total BNP ratio was lower in mild heart failure, which make cGMP / BNP ratio increasing to compensate for heart failure. Deteriorating renal function during treatment for acute heart failure is well known sign for poor prognosis. Therefore, early detection is important. In this study, we found that the NT-proBNP / mature BNP ratio increased preceding to the deterioration of renal function in acute heart failure patients.
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| Academic Significance and Societal Importance of the Research Achievements |
急性心不全の代償機構としてproBNP/total BNP比率を下げて代償することは新規の機序であり、今後の心不全の治療や診断に応用ができる可能性がある。proBNP/total BNP比率を決めているのはproBNPへの糖鎖修飾であり、糖鎖修飾の機序を解明することで心不全の患者の予後改善に結びつく可能性がある。急性心不全の治療中の腎機能悪化の早期発見の指標は、これまでたくさんの研究がなされてきたが、決定的なものはなかった。腎機能悪化を早期に予知するほど予防、治療のための介入も早くなり、心不全患者の予後の改善に結びつく可能性が高い。今回の研究で入院3日目に有意な変化が見出され期待できる。
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Report
(4 results)
Research Products
(27 results)
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[Presentation] NRSF-GNAO1-CaMK2 axis exacerbates cardiac remodeling and progresses heart failure by impairing Ca2+homeostasis2020
Author(s)
Inazumi H, Kuwahara K, Kuwabara Y, Nakagawa Y, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Oya M, Yarnada M, Kashihara T, Kurebayashi N, Sugihara M, Nakao K, Kimura T.
Organizer
ESC Congress 2020
Related Report
Int'l Joint Research
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[Presentation] Increased Gao expression underlies cardiac dysfunction and lethal arrhythmias accompanied with abnormal Ca2+ handling2019
Author(s)
Inazumi H, Kuwahara K, Kuwabara Y, Nakagawa Y, Kinoshita H, Moriuchi K, Yanagisawa H, Nishikimi T, Oya M, Yamada M, Kashihara T, Kurebayashi N, Sugihara M, Nakao K, Kimura T.
Organizer
European Society of Cardiology2019
Related Report
Int'l Joint Research
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[Presentation] Increased expression of Gαo plays a pivotal role in the progression of heart failure by impairing Ca2+ homeostasis2019
Author(s)
H Inazumi, K Kuwahara, Y Kuwabara, Y Nakagawa, H Kinoshita, K Moriuchi, H Yanagisawa , T Nishikimi , M Oya, M Yamada, T Kashihara, N Kurebayashi, M Sugihara, K Nakao, T Kimura
Organizer
第36回国際心臓研究学会日本部会
Related Report
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