Coronary Microvascular Dysfunction Underlying Non-Ischemic Heart Failure and Development of Potential Therapeutic Strategies

• Project/Area Number: 18K08110
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Kumamoto University
• Principal Investigator: Tsujita Kenichi 熊本大学, 大学院生命科学研究部(医), 教授 (60571263)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 心不全 / 冠微小循環障害 / 心筋症 / 心筋虚血 / 冠内圧 / 冠血流 / 心筋エネルギー代謝 / 微小循環障害

Outline of Final Research Achievements

Microvascular Dysfunction (MVD) has been thought to be one of the potential mechanisms underlying the heart failure in elderly. However, established diagnostic procedures themselves have been lacking.
In this research project, the investigators have established an diagnostic scheme of MVD invasively and non-invasively in non-ischemic heart failure patients in the clinical setting and proposed several potential therapeutic options and added considerable description in the updated guideline published by the Japanese Circulation Society.

Academic Significance and Societal Importance of the Research Achievements

本研究から得られるデータは、そのまま高齢者心不全の基盤病態解明に直結し、治療戦略提示に繋がるものである。
本研究から、MVD評価指標の確立・標準化への道筋がつけられ、今後本邦並びに海外においても一定の侵襲的診断手順IDPが標準的に行われ、MVD研究の共通言語となり得る。国内におけるMVD研究組織が構築され、更には国際共同研究が推進される事で、MVD研究のスピードアップが期待される。本研究からMVDへの治療戦略としていくつかのオプションの可能性が示唆され、これらの成果がガイドラインに記載されたことは社会的意義が大きい。

Research Products

• [Int'l Joint Research] University of Adelaide/The University of Sydney/Monash University(オーストラリア)
• [Int'l Joint Research] OLV-Aalst(ベルギー)
• [Int'l Joint Research] McGill University(カナダ)
• [Int'l Joint Research] Robert-Bosch-Krankenhaus/University of Copenhagen(デンマーク)
• [Int'l Joint Research] University Medical Centre in Mainz/University of Essen/Robert-Bosch-Krankenhaus(ドイツ)
• [Int'l Joint Research]
• [Int'l Joint Research] Vita Salute University/Fondazione Policlinico Universitario A/Consiglio Nazionale delle Ricerche(イタリア)
• [Int'l Joint Research] Universidad Complutense de Madrid(スペイン)
• [Int'l Joint Research] University of Glasgow/University of London(英国)
• [Int'l Joint Research] Emory University/Yale University/University of Florida,(米国)
• [Int'l Joint Research] University of Adelaide(オーストラリア)
• [Journal Article] CT Extracellular Volume Fraction versus Myocardium-to-Lumen Signal Ratio for Cardiac Amyloidosis (2023)
  • Author(s): Kidoh Masafumi、Oda Seitaro、Takashio Seiji、Hirakawa Kyoko、Kawano Yawara、Shiraishi Shinya、Hayashi Hidetaka、Nakaura Takeshi、Nagayama Yasunori、Funama Yoshinori、Ueda Mitsuharu、Tsujita Kenichi、Hirai Toshinori
  • Journal Title: Radiology Volume: 306 Issue: 3
  • DOI: 10.1148/radiol.220542
  • Peer Reviewed / Open Access
• [Journal Article] Discordance between fractional flow reserve and instantaneous wave-free ratio in patients with severe aortic stenosis: A retrospective cohort study (2023)
  • Author(s): Yamanaka F, Shishido K, Yokota S, Moriyama N, Ochiai T, Yamada T, Hayashi T, Miyashita H, Yokoyama H, Yamanaga K, Tabata N, Yamaguchi M, Yamagishi T, Matsumoto T, Tobita K, Mizuno S, Tanaka Y, Murakami M, Takahashi S, Saito S, Tsujita K.
  • Journal Title: Journal of Cardiology Volume: 81 Issue: 2 Pages: 138-143
  • DOI: 10.1016/j.jjcc.2022.08.005
  • Peer Reviewed / Open Access
• [Journal Article] Clinical impact of beta-blockers at discharge on long-term clinical outcomes in patients with non-reduced ejection fraction after acute myocardial infarction (2023)
  • Author(s): Sakagami A, Soeda T, Saito Y, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, Suwa S, Fujimoto K, Dai K, Morita T, Shimizu W, Hirohata A, Morita Y, Inoue T, Okamura A, Mano T, Wake M, Tanabe K, Shibata Y, Owa M, Tsujita K, et al.
  • Journal Title: Journal of Cardiology Volume: 81 Issue: 1 Pages: 83-90
  • DOI: 10.1016/j.jjcc.2022.08.002
  • Peer Reviewed / Open Access
• [Journal Article] A Randomized, Double-Blind Comparison Study of Royal Jelly to Augment Vascular Endothelial Function in Healthy Volunteers (2022)
  • Author(s): Fujisue Koichiro、Yamamoto Eiichiro、Sueta Daisuke、Arima Yuichiro、Hirakawa Kyoko、et al.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 9 Pages: 1285-1294
  • DOI: 10.5551/jat.63044
  • NAID: 130008093190
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Effect of the ALDH2 Variant on the Prevalence of Atrial Fibrillation in Habitual Drinkers (2022)
  • Author(s): Yamashita T, Arima Y, Hoshiyama T, Tabata N, Sueta D, Kawahara Y, Ito M, Kanazawa H, Ishii M, Yamanaga K, Hanatani S, Takashio S, Araki S, Suzuki S, Yamamoto E, Kaikita K, Oniki K, Saruwatari J, Matsushita K, Tsujita K.
  • Journal Title: JACC: Asia Volume: 2 Issue: 1 Pages: 62-70
  • DOI: 10.1016/j.jacasi.2021.10.009
  • Peer Reviewed / Open Access
• [Journal Article] Assessing the treatment effect of daratumumab by serial measurements of cardiac biomarkers and imaging parameters in light-chain cardiac amyloidosis (2022)
  • Author(s): Tokai Tatsuya、Takashio Seiji、Kawano Yawara、Kidoh Masafumi、Oda Seitaro、Matsuoka Masao、Tsujita Kenichi
  • Journal Title: Journal of Cardiology Cases Volume: 26 Issue: 4 Pages: 301-304
  • DOI: 10.1016/j.jccase.2022.06.008
  • Peer Reviewed / Open Access
• [Journal Article] Recovery from AA amyloidosis-cardiomyopathy complexed with unicentric Castleman disease (2022)
  • Author(s): Imamura Kanako、Kojima Sunao、Imamura Takahisa、Tsujita Kenichi
  • Journal Title: BMJ Case Reports Volume: 15 Issue: 8 Pages: e250338-e250338
  • DOI: 10.1136/bcr-2022-250338
  • Peer Reviewed / Open Access
• [Journal Article] Evolocumab for prevention of microvascular dysfunction in patients undergoing percutaneous coronary intervention: the randomised, open-label EVOCATION trial (2022)
  • Author(s): Ishihara Masaharu、Asakura Masanori、Hibi Kiyoshi、Okada Kozo、Shimizu Wataru、Takano Hitoshi、Suwa Satoru、Fujii Kenshi、Okumura Yasuo、Mano Toshiaki、Tsujita Kenichi、Igeta Masataka、Okamoto Rika、Suna Shinichiro
  • Journal Title: EuroIntervention Volume: 18 Issue: 8 Pages: e647-e655
  • DOI: 10.4244/eij-d-22-00269
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between cardiac images, biomarkers, and amyloid load in wild-type transthyretin amyloid cardiomyopathy (2022)
  • Author(s): Morioka M, Takashio S, et al.
  • Journal Title: JAHA Volume: 11 Issue: 12
  • DOI: 10.1161/jaha.121.024717
  • Peer Reviewed / Open Access
• [Journal Article] Increased soluble programed cell death-ligand 1 is associated with acute coronary syndrome (2022)
  • Author(s): Fujisue Koichiro、Yamamoto Eiichiro、Sueta Daisuke、Takae Masafumi、Nishihara Taiki、Komorita Takashi、Usuku Hiroki、Yamanaga Kenshi、Ito Miwa、Hoshiyama Tadashi、Kanazawa Hisanori、Takashio Seiji、Arima Yuichiro、Araki Satoshi、Soejima Hirofumi、Kaikita Koichi、Matsushita Kenichi、Tsujita Kenichi
  • Journal Title: International Journal of Cardiology Volume: 349 Pages: 1-6
  • DOI: 10.1016/j.ijcard.2021.11.060
  • Peer Reviewed / Open Access
• [Journal Article] Sex-related differences in the clinical characteristics of wild-type transthyretin amyloidosis cardiomyopathy (2022)
  • Author(s): Takashio Seiji、Yamada Toshihiro、Nishi Masato、Morioka Mami、Fujiyama Akira、Nakashima Naoya、Hirakawa Kyoko、Hanatani Shinsuke、Usuku Hiroki、Yamamoto Eiichiro、Ueda Mitsuharu、Matsushita Kenichi、Tsujita Kenichi
  • Journal Title: Journal of Cardiology Volume: 79 Issue: 1 Pages: 50-57
  • DOI: 10.1016/j.jjcc.2021.10.007
  • Peer Reviewed / Open Access
• [Journal Article] East Asian variant aldehyde dehydrogenase type 2 genotype exacerbates ischemia/reperfusion injury with ST-elevation myocardial infarction in men: possible sex differences (2022)
  • Author(s): Ishida T, Arima Y, Mizuno Y, Harada E, Yamashita T, Sueta D, Sakamoto K, Suzuki S, Kaikita K, Yamada Y, Shimomura H, Oniki K, Saruwatari J, Hokimoto S, Yasue H, Tsujita K.
  • Journal Title: Heart and Vessels Volume: 37 Issue: 2 Pages: 184-193
  • DOI: 10.1007/s00380-021-01907-x
  • Peer Reviewed / Open Access
• [Journal Article] Realistic detection of natural history of early coronary atherosclerosis: Best part of computed tomography-derived fractional flow reserve? (2021)
  • Author(s): Tsujita Kenichi
  • Journal Title: International Journal of Cardiology Volume: 344 Pages: 34-35
  • DOI: 10.1016/j.ijcard.2021.10.016
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of left atrial strain in patients with wild‐type transthyretin amyloid cardiomyopathy (2021)
  • Author(s): Oike Fumi、Usuku Hiroki、Yamamoto Eiichiro、Yamada Toshihiro、Egashira Koichi、Morioka Mami、Nishi Masato、et al.
  • Journal Title: ESC Heart Failure Volume: 8 Issue: 6 Pages: 5316-5326
  • DOI: 10.1002/ehf2.13621
  • Peer Reviewed / Open Access
• [Journal Article] Improvement of Vascular Endothelial Function Reflects Nonrecurrence After Catheter Ablation for Atrial Fibrillation (2021)
  • Author(s): Kanazawa Hisanori、Kaikita Koichi、Ito Miwa、Kawahara Yusei、Hoshiyama Tadashi、Kanemaru Yusuke、Kiyama Takuya、Iwashita Satomi、Tabata Noriaki、Yamanaga Kenshi、Fujisue Koichiro、Sueta Daisuke、Takashio Seiji、Arima Yuichiro、Araki Satoshi、Usuku Hiroki、Nakamura Taishi、et al.
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 17
  • DOI: 10.1161/jaha.121.021551
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of liver stiffness assessed by fibrosis‐4 index in patients with heart failure (2021)
  • Author(s): Takae Masafumi、Fujisue Koichiro、Yamamoto Eiichiro、Egashira Koichi、Komorita Takashi、Oike Fumi、Nishihara Taiki、Yamamoto Masahiro、Hirakawa Kyoko、Tabata Noriaki、Tokitsu Takanori、Yamanaga Kenshi、Sueta Daisuke、Hanatani Shinsuke、Nakamura Taishi、Usuku Hiroki、Araki Satoshi、Arima Yuichiro、et al.
  • Journal Title: ESC Heart Failure Volume: 8 Issue: 5 Pages: 3809-3821
  • DOI: 10.1002/ehf2.13351
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics and prognosis of patients with microvascular angina: an international and prospective cohort study by the Coronary Vasomotor Disorders International Study (COVADIS) Group (2021)
  • Author(s): Shimokawa Hiroaki、Suda Akira、Takahashi Jun、Berry Colin、Camici Paolo G、Crea Filippo、Escaned Javier、Ford Tom、Yii Eric、Kaski Juan Carlos、Kiyooka Takahiko、Mehta Puja K、Ong Peter、Ozaki Yukio、Pepine Carl、Rimoldi Ornella、Safdar Basmah、Sechtem Udo、Tsujita Kenichi、et al.
  • Journal Title: European Heart Journal Volume: 42 Issue: 44 Pages: 4592-4600
  • DOI: 10.1093/eurheartj/ehab282
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of Reactive Oxidative Metabolites Among New Categories of Nonischemic Heart Failure (2021)
  • Author(s): Nishihara Taiki、Yamamoto Eiichiro、Sueta Daisuke、Fujisue Koichiro、Usuku Hiroki、Oike Fumi、Takae Masafumi、Tabata Noriaki、Ito Miwa、Yamanaga Kenshi、Kanazawa Hisanori、Arima Yuichiro、Araki Satoshi、Takashio Seiji、Nakamura Taishi、Suzuki Satoru、Sakamoto Kenji、Izumiya Yasuhiro、Kaikita Koichi、Tsujita Kenichi
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 7
  • DOI: 10.1161/jaha.120.016765
  • Peer Reviewed / Open Access
• [Journal Article] Murine neonatal ketogenesis preserves mitochondrial energetics by preventing protein hyperacetylation (2021)
  • Author(s): Arima Yuichiro、Nakagawa Yoshiko、Takeo Toru、Ishida Toshifumi、Yamada Toshihiro、et al.
  • Journal Title: Nature Metabolism Volume: 3 Issue: 2 Pages: 196-210
  • DOI: 10.1038/s42255-021-00342-6
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Two-Year Outcomes of Asymptomatic vs. Symptomatic Patients After Deferral of Revascularization Based on Fractional Flow Reserve ― Insights From the J-CONFIRM Registry ― (2020)
  • Author(s): Horie Kazunori、Kuramitsu Shoichi、Matsuo Hitoshi、Shinozaki Tomohiro、Takashima Hiroaki、Shiono Yasutsugu、Terai Hidenobu、Kikuta Yuetsu、Ishihara Takayuki、Saigusa Tatsuya、Sakamoto Tomohiro、Asano Taku、Tsujita Kenichi、et al.
  • Journal Title: Circulation Reports Volume: 2 Issue: 12 Pages: 744-752
  • DOI: 10.1253/circrep.CR-20-0110
  • NAID: 130007953506
  • ISSN: 2434-0790
  • Year and Date: 2020-12-10
  • Peer Reviewed / Open Access
• [Journal Article] Temporal Change in Longitudinal Strain After Domino Liver Transplantation With Liver Grafts Explanted From Patients With Hereditary Amyloidogenic Transthyretin Amyloidosis (2020)
  • Author(s): Usuku Hiroki、Yamamoto Eiichiro、Nishi Masato、Komorita Takashi、et al.
  • Journal Title: Circulation Reports Volume: 2 Issue: 12 Pages: 730-738
  • DOI: 10.1253/circrep.CR-20-0106
  • NAID: 130007953499
  • ISSN: 2434-0790
  • Year and Date: 2020-12-10
  • Peer Reviewed / Open Access
• [Journal Article] Transthyretin Amyloid Cardiomyopathy Diagnosed on Incidental Myocardial Uptake During Bone Scintigraphy (2020)
  • Author(s): Ikebe So、Takashio Seiji、Nishi Masato、Morioka Mami、Tsujita Kenichi
  • Journal Title: Circulation Journal Volume: 84 Issue: 4 Pages: 679
  • DOI: 10.1253/circj.CJ-19-1155
  • NAID: 130007815674
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-03-25
  • Peer Reviewed / Open Access
• [Journal Article] Utility of Kumamoto Criteria in Diagnosing Transthyretin Cardiac Amyloidosis in Real-World Practice ― Reply ― (2020)
  • Author(s): Takashio Seiji、Marume Kyohei、Nishi Masato、Kaikita Koichi、Tsujita Kenichi
  • Journal Title: Circulation Journal Volume: 84 Issue: 4 Pages: 681-682
  • DOI: 10.1253/circj.CJ-20-0059
  • NAID: 130007815678
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-03-25
  • Peer Reviewed / Open Access
• [Journal Article] Role of acetylcholine spasm provocation test as a pathophysiological assessment in nonobstructive coronary artery disease (2020)
  • Author(s): Suzuki Satoru、Kaikita Koichi、Yamamoto Eiichiro、Jinnouchi Hideaki、Tsujita Kenichi
  • Journal Title: Cardiovascular Intervention and Therapeutics Volume: 36 Issue: 1 Pages: 39-51
  • DOI: 10.1007/s12928-020-00720-z
  • NAID: 40022470132
  • Peer Reviewed / Open Access
• [Journal Article] International prospective cohort study of microvascular angina ? Rationale and design (2020)
  • Author(s): Suda Akira、Takahashi Jun、Beltrame John F.、Berry Colin、Camici Paolo G.、Crea Filippo、Escaned Javier、Ford Tom、Carlos Kaski Juan、Kiyooka Takahiko、Metha Puja K.、Ong Peter、Ozaki Yukio、Pepine Carl、Rimoldi Ornella、Safdar Basmah、Sechtem Udo、Tsujita Kenichi、Yii Eric、Noel Bairey Merz C.、Shimokawa Hiroaki
  • Journal Title: IJC Heart & Vasculature Volume: 31 Pages: 100630-100630
  • DOI: 10.1016/j.ijcha.2020.100630
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of cancer history on clinical outcome in patients undergoing transcatheter edge-to-edge mitral repair (2020)
  • Author(s): Tabata Noriaki、Weber Marcel、Sugiura Atsushi、Ozturk Can、Tsujita Kenichi、Nickenig Georg、Sinning Jan-Malte
  • Journal Title: Clinical Research in Cardiology Volume: 110 Issue: 3 Pages: 440-450
  • DOI: 10.1007/s00392-020-01770-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Placebo-Controlled, Double-Blind Study of Empagliflozin (EMPA) and Implantable Cardioverter-Defibrillator (EMPA-ICD) in Patients with Type 2 Diabetes (T2DM): Rationale and Design (2020)
  • Author(s): Fujiki Shinya、Iijima Kenichi、Okabe Masaaki、Niwano Shinichi、Tsujita Kenichi、et al.
  • Journal Title: Diabetes Therapy Volume: 11 Issue: 11 Pages: 2739-2755
  • DOI: 10.1007/s13300-020-00924-9
  • Peer Reviewed / Open Access
• [Journal Article] JCS 2020 Guideline on Diagnosis and Treatment of Cardiac Amyloidosis (2020)
  • Author(s): Kitaoka H, Izumi C, Izumiya Y, Inomata T, Ueda M, Kubo T, Koyama J, Sano M, Sekijima Y, Tahara N, Tsukada N, Tsujita K, Tsutsui H, Tomita T, Amano M, Endo J, Okada A, Oda S, Takashio S, Baba Y, Misumi Y, Yazaki M, Anzai T, Ando Y, Isobe M, Kimura T, Fukuda K; Japanese Circulation Society Joint Working Group.
  • Journal Title: Cir J Volume: 84 Issue: 9 Pages: 1610-1671
  • DOI: 10.1253/circj.cj-20-0110
  • NAID: 130007890677
  • Peer Reviewed / Open Access
• [Journal Article] Impact of hydrostatic pressure on fractional flow reserve: in vivo experimental study of anatomical height difference of coronary arteries (2020)
  • Author(s): Nagamatsu Suguru、Sakamoto Kenji、Yamashita Takayoshi、Sato Ryota、Tabata Noriaki、Motozato Kota、Yamanaga Kenshi、et al.
  • Journal Title: Journal of Cardiology Volume: - Issue: 1 Pages: 73-79
  • DOI: 10.1016/j.jjcc.2020.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Association of short-term exposure to air pollution with myocardial infarction with and without obstructive coronary artery disease (2020)
  • Author(s): Ishii Masanobu、Seki Tomotsugu、Kaikita Koichi、Sakamoto Kenji、et al.
  • Journal Title: European Journal of Preventive Cardiology Volume: - Issue: 13 Pages: 1435-1444
  • DOI: 10.1177/2047487320904641
  • Peer Reviewed / Open Access
• [Journal Article] H 2 FPEF score for predicting future heart failure in stable outpatients with cardiovascular risk factors (2020)
  • Author(s): Suzuki Satoru、Kaikita Koichi、Yamamoto Eiichiro、Sueta Daisuke、et al.
  • Journal Title: ESC Heart Failure Volume: 7 Issue: 1 Pages: 66-75
  • DOI: 10.1002/ehf2.12570
  • Peer Reviewed / Open Access
• [Journal Article] Two-Year Outcomes After Deferral of Revascularization Based on Fractional Flow Reserve (2020)
  • Author(s): Kuramitsu Shoichi、Matsuo Hitoshi、Shinozaki Tomohiro、et al.
  • Journal Title: Circulation: Cardiovascular Interventions Volume: 13 Issue: 1
  • DOI: 10.1161/circinterventions.119.008355
  • Peer Reviewed / Open Access
• [Journal Article] Clinical usefulness of quantification of myocardial blood flow and flow reserve using CZT-SPECT for detecting coronary artery disease in patients with normal stress perfusion imaging (2020)
  • Author(s): Shiraishi Shinya、Tsuda Noriko、Sakamoto Fumi、Ogasawara Kouji、Tomiguchi Seiji、Tsujita Kenichi、Yamashita Yasuyuki
  • Journal Title: Journal of Cardiology Volume: 75 Issue: 4 Pages: 400-409
  • DOI: 10.1016/j.jjcc.2019.09.006
  • Peer Reviewed / Open Access
• [Journal Article] Characteristics and in-hospital mortality of patients with myocardial infarction in the absence of obstructive coronary artery disease in super-aging society (2020)
  • Author(s): Ishii Masanobu、Kaikita Koichi、Sakamoto Kenji、Seki Tomotsugu、Kawakami Koji、Nakai Michikazu、Sumita Yoko、Nishimura Kunihiro、Miyamoto Yoshihiro、Noguchi Teruo、Yasuda Satoshi、Tsutsui Hiroyuki、Komuro Issei、Saito Yoshihiko、Ogawa Hisao、Tsujita Kenichi
  • Journal Title: International Journal of Cardiology Volume: 301 Pages: 108-113
  • DOI: 10.1016/j.ijcard.2019.09.037
  • Peer Reviewed / Open Access
• [Journal Article] Cardiomyocyte Sirt (Sirtuin) 7 Ameliorates Stress-Induced Cardiac Hypertrophy by Interacting With and Deacetylating GATA4 (2020)
  • Author(s): Yamamura Satoru、Izumiya Yasuhiro、Araki Satoshi、Nakamura Taishi、et al.
  • Journal Title: Hypertension Volume: 75 Issue: 1 Pages: 98-108
  • DOI: 10.1161/hypertensionaha.119.13357
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] A Statement on the Appropriate Administration of Tafamidis in Patients With Transthyretin Cardiac Amyloidosis (2019)
  • Author(s): Endo Jin、Sano Motoaki、Izumiya Yasuhiro、Tsujita Kenichi、Nakamura Kazufumi、Tahara Nobuhiro、Kuwahara Koichiro、Inomata Takayuki、Ueda Mitsuharu、Sekijima Yoshiki、Ando Yukio、Tsutsui Hiroyuki、Isobe Mitsuaki、Fukuda Keiichi
  • Journal Title: Circulation Journal Volume: 84 Issue: 1 Pages: 15-17
  • DOI: 10.1253/circj.CJ-19-0811
  • NAID: 130007772713
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-12-25
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Takotsubo Cardiomyopathy Mimicking Acute Coronary Syndrome ― Extracellular Volume Quantification Using Cardiac Computed Tomography ― (2019)
  • Author(s): Sueta Daisuke、Oda Seitaro、Yamamoto Eiichiro、Nishi Masato、Kaikita Koichi、Kidoh Masafumi、Utsunomiya Daisuke、Nakaura Takeshi、Yamashita Yasuyuki、Tsujita Kenichi
  • Journal Title: Circulation Journal Volume: 83 Issue: 7 Pages: 1613
  • DOI: 10.1253/circj.CJ-18-1062
  • NAID: 130007666936
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-06-25
  • Peer Reviewed
• [Journal Article] Clinical significance of serum magnesium levels in patients with heart failure with preserved ejection fraction (2019)
  • Author(s): Nishihara Taiki、Yamamoto Eiichiro、Sueta Daisuke、Fujisue Koichiro、Usuku Hiroki、Oike Fumi、Takae Masafumi、Arima Yuichiro、Araki Satoshi、Takashio Seiji、Nakamura Taishi、Suzuki Satoru、Sakamoto Kenji、Soejima Hirofumi、Kawano Hiroaki、Kaikita Koichi、Tsujita Kenichi
  • Journal Title: Medicine Volume: 98 Issue: 38 Pages: e17069-e17069
  • DOI: 10.1097/md.0000000000017069
  • Peer Reviewed / Open Access
• [Journal Article] H2FPEF Score as a Prognostic Value in HFpEF Patients (2019)
  • Author(s): Sueta Daisuke、Yamamoto Eiichiro、Nishihara Taiki、Tokitsu Takanori、Fujisue Koichiro、Oike Fumi、Takae Masafumi、Usuku Hiroki、Takashio Seiji、Arima Yuichiro、Suzuki Satoru、Nakamura Taishi、Ito Miwa、Kanazawa Hisanori、Sakamoto Kenji、Kaikita Koichi、Tsujita Kenichi
  • Journal Title: American Journal of Hypertension Volume: 32 Issue: 11 Pages: 1082-1090
  • DOI: 10.1093/ajh/hpz108
  • Peer Reviewed / Open Access
• [Journal Article] Coronary arterial microfistulae with meandering dilated coronary arteries and noncompaction-like myocardium (2019)
  • Author(s): Yuki Hideaki、Arima Yuichiro、Utsunomiya Daisuke、Fujisue Koichiro、Kidoh Masafumi、Oda Seitaro、Nakaura Takeshi、Yamashita Yasuyuki、Tsujita Kenichi
  • Journal Title: Cardiology Journal Volume: 26 Issue: 1 Pages: 95-96
  • DOI: 10.5603/cj.2019.0013
  • Peer Reviewed
• [Journal Article] Current status and future perspective of structural heart disease intervention (2019)
  • Author(s): Tabata Noriaki、Sinning Jan-Malte、Kaikita Koichi、Tsujita Kenichi、Nickenig Georg、Werner Nikos
  • Journal Title: Journal of Cardiology Volume: in press Issue: 1 Pages: 1-12
  • DOI: 10.1016/j.jjcc.2019.02.022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Basal septal perforator vein mimicking the “late iodine enhancement” in delayed phase cardiac CT for myocardial scar assessment (2019)
  • Author(s): Kidoh Masafumi、Oda Seitaro、Utsunomiya Daisuke、Emoto Takafumi、Nakaura Takeshi、Nagayama Yasunori、Yamamoto Masahiro、Sakamoto Kenji、Yamamoto Eiichiro、Kaikita Koichi、Tsujita Kenichi、Yamashita Yasuyuki
  • Journal Title: Radiology Case Reports Volume: 14 Issue: 5 Pages: 588-590
  • DOI: 10.1016/j.radcr.2019.02.016
  • Peer Reviewed
• [Journal Article] Myocardial Ischemia Suppresses Ketone Body Utilization (2019)
  • Author(s): Arima Yuichiro、Izumiya Yasuhiro、Ishida Toshifumi、Takashio Seiji、Ishii Masanobu、Sueta Daisuke、Fujisue Koichiro、Sakamoto Kenji、Kaikita Koichi、Tsujita Kenichi
  • Journal Title: Journal of the American College of Cardiology Volume: 73 Issue: 2 Pages: 246-247
  • DOI: 10.1016/j.jacc.2018.10.040
  • Peer Reviewed
• [Journal Article] Coronary blood flow volume change is negatively associated with platelet aggregability in patients with non-obstructive ischemic heart disease who have no anti-platelet agents (2019)
  • Author(s): Takae Masafumi、Yamamoto Eiichiro、Fujisue Koichiro、et al
  • Journal Title: International Journal of Cardiology Volume: 277 Pages: 3-7
  • DOI: 10.1016/j.ijcard.2018.08.068
  • Peer Reviewed
• [Journal Article] Akt1-Mediated Muscle Growth Promotes Blood Flow Recovery After Hindlimb Ischemia by Enhancing Heme Oxygenase-1 in Neighboring Cells (2018)
  • Author(s): Onoue Yoshiro、Izumiya Yasuhiro、Hanatani Shinsuke、Ishida Toshifumi、Arima Yuichiro、Yamamura Satoru、Kimura Yuichi、Araki Satoshi、Ishii Masanobu、Nakamura Taishi、Oimatsu Yu、Sakamoto Kenji、Yamamoto Eiichiro、Kojima Sunao、Kaikita Koichi、Tsujita Kenichi
  • Journal Title: Circulation Journal Volume: 82 Issue: 11 Pages: 2905-2912
  • DOI: 10.1253/circj.CJ-18-0135
  • NAID: 40021697306
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2018-10-25
  • Peer Reviewed / Open Access
• [Journal Article] Coronary Artery Plaque Regression by a PCSK9 Antibody and Rosuvastatin in Double-heterozygous Familial Hypercholesterolemia with an <i>LDL Receptor</i> Mutation and a <i>PCSK9</i> V4I Mutation (2018)
  • Author(s): Shirahama Ryo、Ono Takamichi、Nagamatsu Suguru、Sueta Daisuke、Takashio Seiji、Chitose Tadasuke、Fujisue Koichiro、Sakamoto Kenji、Yamamoto Eiichiro、Izumiya Yasuhiro、Kaikita Koichi、Hokimoto Seiji、Hori Mika、Harada-Shiba Mariko、Kajiwara Ichiro、Ogawa Hisao、Tsujita Kenichi
  • Journal Title: Internal Medicine Volume: 57 Issue: 24 Pages: 3551-3557
  • DOI: 10.2169/internalmedicine.1060-18
  • NAID: 130007531213
  • Peer Reviewed
• [Journal Article] Non-Val30Met mutation, septal hypertrophy, and cardiac denervation in patients with mutant transthyretin amyloidosis (2018)
  • Author(s): Hirakawa Kyoko、Takashio Seiji、Marume Kyohei、Yamamoto Masahiro、Hanatani Shinsuke、Yamamoto Eiichiro、Sakamoto Kenji、Izumiya Yasuhiro、Kaikita Koichi、Oda Seitaro、Utsunomiya Daisuke、Shiraishi Shinya、Ueda Mitsuharu、Yamashita Taro、Yamashita Yasuyuki、Ando Yukio、Tsujita Kenichi
  • Journal Title: ESC Heart Failure Volume: 6 Issue: 1 Pages: 122-130
  • DOI: 10.1002/ehf2.12361
  • Peer Reviewed / Open Access
• [Presentation] Clinical characteristics, patient selection and clinical outcomes of tafamidis treatment in transthyretin amyloidosis cardiomyopathy. (2022)
  • Author(s): Takashio S, Morioka M, Fujiyama A, Oike F, Hanatani S, Usuku H, Yamamoto E, Matsushita K, Tsujita K
  • Organizer: European Society of Cardiology-ESC Congress 2022
  • Int'l Joint Research
• [Presentation] Change in echocardiography in patients with transthyretin amyloid cardiomyopathy with tafamidis treatment (2022)
  • Author(s): Morioka M, Nakashima M, Hirakawa K, Hanatani S, Usuku H, Takashio S, Yamamoto E, Matsushita K, Tsujita K
  • Organizer: European Society of Cardiology-ESC Congress 2022
  • Int'l Joint Research
• [Presentation] Usefulness of Automatic Assessment for Longitudinal Strain to Diagnose Wild-Type Transthyretin Amyloid Cardiomyopathy (2022)
  • Author(s): Usuku K, Yamamoto E, Fujisaki T, Egashira K, Oike F, Fujisue K, Sueta D, Takashio S, Tsujita K
  • Organizer: American Heart Association Scientific Sessions 2022
  • Int'l Joint Research
• [Presentation] Comparison of Transthyretin Amyloid Cardiomyopathy Patients Taking Tafamidis and Those Not Taking Tafamidis Using Two-Dimensional Speckle Tracking Echocardiography (2022)
  • Author(s): Oike F, Usuku H, Egashira K, Komorita T, Fujisue K, Sueta D, Takashio S, Yamamoto E, Tujita K
  • Organizer: American Heart Association Scientific Sessions 2022
  • Int'l Joint Research
• [Presentation] What effect do cardiovascular medications & diet have on vascular aging? (2022)
  • Author(s): Tsujita K
  • Organizer: The 11th International COngress on Lipid & Atherosclerosis
  • Int'l Joint Research / Invited
• [Presentation] 心不全に潜む冠微小循環障害定量評価への挑戦 (2022)
  • Author(s): 辻田賢一
  • Organizer: 第26回日本心不全学会学術集会
  • Invited
• [Presentation] Gender Differences in Clinical Characteristics in Wild-Type Transthyretin Amyloidosis Cardiomyopathy (2021)
  • Author(s): Takashio S, Morioka M, Nishi M, Nakashima N, Yamada T, Hirakawa K, Hanatani S, Usuku H, Yamamoto E, Matsushita K, Tsujita K
  • Organizer: European Society of Cardiology-ESC Congress 2021
  • Int'l Joint Research
• [Presentation] Correlations between Pathological Deposition and Non-Invasive Diagnostic Modalities Like 99 mTc-PYP Scintigraphy, Cardiac Magnetic Resonance, GLS in Patients with Transthyretin Cardiac Amyloidosis (2021)
  • Author(s): Morioka M, Takashio S, Nakashima N, Nishi M, Hirakawa K, Hanatani S, Usuku H, YamamotoE, Matsushita K, Kaikita K, Tsujita K
  • Organizer: European Society of Cardiology-ESC Congress 2021
  • Int'l Joint Research
• [Presentation] Prognostic Significance of Soluble Programed Cell Death Ligand-1 on Cardiovascular Outcomes in Patients with Atherosclerotic Cardiovascular Dsease (2021)
  • Author(s): Miyazaki S, Fujisue K, Yamanaga K, Yamamoto E, Egashira K, Komorita T, Sueta D, Usuku H, Araki S, Takasiho S, Matsushita K, Tsujita K
  • Organizer: American Heart Association Scientific Sessions 2021
  • Int'l Joint Research
• [Presentation] Comprehensive lipid management in Coronary Artery Disease with highly purified EPA. (2021)
  • Author(s): Tsujita K
  • Organizer: The 19th International Symposium on Atherosclerosis (ISA 2021)
  • Int'l Joint Research / Invited
• [Presentation] The Current Status of Myocardial Infarction with Nonobstructive Coronary Arteries in Japan: Report from a Nationwide Claims Database, JROAD-DPC database. (2021)
  • Author(s): Ishii M, Otsuka Y, Tsujita K.
  • Organizer: 第86回日本循環器学会総会・学術集会
  • Int'l Joint Research / Invited
• [Presentation] A Randomized, Double-blind Comparison Study of Royal Jelly to Improve Endothelial Function in Healthy Volunteers (2020)
  • Author(s): Fujisue K, Tsujita K
  • Organizer: American Heart Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] Appropriate Timing of Pacemaker Implantation in Patients With Wild-Type and Variant Amyloidogenic Transthyretin Cardiac Amyloidosis (2020)
  • Author(s): Kawahara Y, Ito M, Hoshiyama T, Kanazawa H, Tsujita K
  • Organizer: American Heart Association Scientific Sessions
  • Int'l Joint Research
• [Presentation] 二次予防における脂質低下療法の意義 (2020)
  • Author(s): 辻田賢一
  • Organizer: 第52回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] 非アルコール性脂肪肝/脂肪肝炎と心血管病をつなぐ分子メカニズム (2020)
  • Author(s): 有馬勇一郎，辻田賢一
  • Organizer: 第52回日本動脈硬化学会総会・学術集会
  • Invited
• [Presentation] 熊本県における循環器救急の現状と課題 (2019)
  • Author(s): 辻田賢一
  • Organizer: 第23回日本心不全学会学術集会
  • Invited
• [Presentation] In Vivo Optical Coherence Tomography Visualization of Intraplague Neovasculization at the Site of Coronary Vasospasm (2019)
  • Author(s): Tsujita K
  • Organizer: ASIAN PACIFIC SCIETY of CARDIOLOGY CONGRESS
  • Int'l Joint Research / Invited
• [Presentation] Insufficient Neonatal Ketogenesis Triggers the Susceptible Trait for Hepatic Steatosis (2018)
  • Author(s): Yuichiro Arima
  • Organizer: American Heart Association Scientific Sessions 2018
  • Int'l Joint Research
• [Book] CATHLAB JIN (2022)
  • Author(s): 辻田賢一
  • Total Pages: 2
  • Publisher: メディカルアイ
  • ISBN: 9784862912572
• [Book] Medical Practice, MINOCA冠動脈閉塞を伴わない心筋梗塞 (2022)
  • Author(s): 石井正将，辻田賢一
  • Total Pages: 3
  • Publisher: 文光堂
• [Book] 冠疾患誌 3：23-26, 2021 大規模データから見たMINOCAの実態 (2021)
  • Author(s): 山永健之，辻田賢一
  • Publisher: 日本冠疾患学会誌
• [Book] 【治療抵抗性高血圧への対処-腎デナベーションを含めて】治療抵抗性高血圧への代替療法としての腎デナベーション (2021)
  • Author(s): 山本 英一郎、辻田 賢一
  • Publisher: (株)ライフメディコム
  • ISBN: 9784898133231
• [Book] 消化器ナーシング2020年5月号 (2020)
  • Author(s): 末田 大輔, 辻田 賢一
  • Publisher: メディカ出版
  • ISBN: 9784840470469
• [Book] 心アミロイドーシスの臨床・画像・病理 トランスサイレチン型心アミロイドーシスの診断のポイント (2020)
  • Author(s): 高潮征爾, 辻田賢一
  • Publisher: The Japanese Society of Medical Imaging
• [Book] MINOCA 循環器内科 (2019)
  • Author(s): 海北幸一、辻田賢一
  • Publisher: 科学評論社
• [Book] 2018 ESC／EACTS:心筋血行再建ガイドラインの概観 特集 虚血性心疾患治療の現在と未来 循環器内科 (2019)
  • Author(s): 辻田賢一，坂本憲治，山本英一郎，海北幸一
  • Publisher: 科学評論社
• [Book] 心筋疾患 褐色細胞腫に伴う心筋症 (2019)
  • Author(s): 坂本憲治、辻田賢一
  • Publisher: 日本臨床 別冊 循環器症候群1
• [Book] 腎神経デナベーションのトランスレーショナルリサーチ 循環制御 (2019)
  • Author(s): 山本英一郎、中村太志、辻田賢一
  • Publisher: 日本循環制御医学会
• [Book] 虚血性心疾患における慢性炎症と急性代謝変容 別冊Bio Clinica (2019)
  • Author(s): 辻田賢一
  • Publisher: 北隆館
• [Remarks] COVADIS
  • URL: https://covadis.online/
• [Remarks] COVADIS
  • URL: https://covadis.online/publications/