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Evaluation of atrial remodeling and its impact on the recurrence after ablation for atrial fibrillation

Research Project

Project/Area Number 18K08113
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53020:Cardiology-related
Research InstitutionKitasato University

Principal Investigator

Fukaya Hidehira  北里大学, 医学部, 講師 (80365105)

Project Period (FY) 2018-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords心房細動 / カテーテルアブレーション / 再発予測 / リモデリング
Outline of Final Research Achievements

This study examined the usefulness of preoperative non-invasive tests for predicting recurrence after catheter ablation for atrial fibrillation.
1) Focusing on the P wave during sinus rhythm before the procedure, we investigated the relationship between the P-wave signal-averaged ECG (P-SAECG) and recurrence after atrial fibrillation ablation. By calculating RMS20 and fPd detected by P-SAECG, we reported that cases showing a decrease in RMS20 or an extension of fPd had significantly higher recurrence rates after catheter ablation.
2) Focusing on the electrocardiogram recorded with preoperative atrial fibrillation, we investigated the relationship between the atrial fibrillation cycle length (FCL) and recurrence after atrial fibrillation ablation. We calculated the cutoff value of FCL that could predict recurrence and reported that cases with longer FCL than this cutoff value had a higher recurrence rate after atrial fibrillation ablation.

Academic Significance and Societal Importance of the Research Achievements

心房細動は加齢に伴い有病率が増える疾患である。心房細動による心不全、脳卒中などの心血管イベント増加が報告されている。カテーテルアブレーションはそれらの発症頻度を低下させる有効な治療法である。

本研究において、心房細動アブレーション後の再発予測が期待される。再発高リスク症例を層別化できることで、アブレーション自体の適応や、再発高リスク症例に対する追加治療の検討などが期待できる。逆の観点から、再発低リスク例を検出することで、不要な治療を避け、医療資源の削減にもつながる可能性が期待できる。

Report

(7 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (6 results)

All 2023 2022 2021 2020 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Atrial late potentials are associated with atrial fibrillation recurrence after catheter ablation2022

    • Author(s)
      Saito, D. Fukaya, H. Oikawa, J. Sato, T. Matsuura, G. Arakawa, Y. Kobayashi, S. Shirakawa, Y. Ishizue, N. Kishihara, J. Niwano, S. Ako, J.
    • Journal Title

      Journal of Arrhythmia

      Volume: 38 Issue: 6 Pages: 991-996

    • DOI

      10.1002/joa3.12786

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reduced atrial conduction velocity is associated with the recurrence of atrial fibrillation after catheter ablation.2022

    • Author(s)
      Sato T, Fukaya H, Oikawa J, Saito D, Matsuura G, Arakawa Y, Kobayashi S, Shirakawa Y, Nishinarita R, Horiguchi A, Ishizue N, Kishihara J, Niwano S, Ako J
    • Journal Title

      Heart and Vessels

      Volume: 37 Issue: 4 Pages: 628-637

    • DOI

      10.1007/s00380-021-01952-6

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] P-wave Duration of Atrial Late Potentials is Associated with the Inducibility of Atrial Tachycardia after Pulmonary Vein Isolation in Patients with Atrial Fibrillation2023

    • Author(s)
      Saito D, Fukaya H, et al
    • Organizer
      The 69th Annual Meeting of The Japanese Heart Rhythm Society
    • Related Report
      2023 Annual Research Report
  • [Presentation] Atrial Late Potentials are Associated with Recurrence of Atrial Fibrillation after Catheter Ablation2021

    • Author(s)
      斎藤大樹、深谷英平、他
    • Organizer
      第85回日本循環器学会学術集会
    • Related Report
      2021 Research-status Report 2020 Research-status Report
  • [Presentation] Reduced atrial conduction velocity is associated with the recurrence of atrial fibrillation after catheter ablation: Insight from an electro-anatomical mapping study2020

    • Author(s)
      佐藤哲郎、深谷英平、他
    • Organizer
      第84回日本循環器学会学術集会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] Fibrillation Cycle Length Predicts Recurrence after Catheter Ablation in Patients with Persistent Atrial Fibrillation2018

    • Author(s)
      深谷英平
    • Organizer
      European Society of Cardiology 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2025-01-30  

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