Residual risk control in familial hypercholesterolemia: Identification of lipids responsible for HDL malignant transformation
| Project/Area Number |
18K08125
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
Ogura Masatsune 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (30532486)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | HDL機能 / 家族性高コレステロール血症 / 動脈硬化予防 / コレステロール搬出能 / リン脂質 / ホスフォリパーゼ / ASCVD / 脂肪酸側鎖 / 冠動脈疾患 / 高密度リポ蛋白 / 残余リスク |
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| Outline of Final Research Achievements |
In this research project, we searched for the lipids that are responsible for making HDL bad in patients with familial hypercholesterolemia (FH). We have previously reported that cholesterol efflux capacity is a more useful residual risk marker than HDL-C levels in patients with FH. However, we faced the challenge of not being able to standardize the method for measuring the efflux capacity. We decided to overcome the problem by identifying the true bad lipids, which are common to both impaired efflux capacity and coronary artery disease, among the HDL components. Therefore, we performed lipidomic analysis of patient HDL fractions and identified several lipid species that were negatively associated with efflux capacity and positively associated with atherosclerosis severity.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究の達成は引き抜き能に代わる動脈硬化予測バイオマーカーの確立や創薬（得られた脂質分子の阻害薬）の基盤を築く。家族性高コレステロール血症（FH）患者のHDL代謝は非FHと大きな差異はないため、全ハイリスク患者におけるLDL-C低下治療後の残余リスク制圧につながる。
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Statement for Appropriate Clinical Use of PCSK9 Inhibitors2018
Author(s)
Nohara Atsushi、Ohmura Hirotoshi、Okazaki Hiroaki、Ogura Masatsune、Kitagawa Kazuo、Koseki Masahiro、Sato Kayoko、Tsukamoto Kazuhisa、Yamashita Shizuya、On behalf of the Japan Atherosclerosis Society Working Group on Statement for Appropriate Use of PCSK9 Inhibitors
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 25
Issue: 8
Pages: 747-750
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2018-08-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] Guidelines for Diagnosis and Treatment of Familial Hypercholesterolemia 20172018
Author(s)
Harada-Shiba Mariko、Arai Hidenori、Ishigaki Yasushi、Ishibashi Shun、Okamura Tomonori、Ogura Masatsune、Dobashi Kazushige、Nohara Atsushi、Bujo Hideaki、Miyauchi Katsumi、Yamashita Shizuya、Yokote Koutaro、Working Group by Japan Atherosclerosis Society for Making Guidance of Familial Hypercholesterolemia
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 25
Issue: 8
Pages: 751-770
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2018-08-01
Related Report
Peer Reviewed / Open Access
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[Journal Article] Guidance for Pediatric Familial Hypercholesterolemia 20172018
Author(s)
Harada-Shiba Mariko、Ohta Takao、Ohtake Akira、Ogura Masatsune、Dobashi Kazushige、Nohara Atsushi、Yamashita Shizuya、Yokote Koutaro、Joint Working Group by Japan Pediatric Society and Japan Atherosclerosis Society for Making Guidance of Pediatric Familial Hypercholesterolemia
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 25
Issue: 6
Pages: 539-553
DOI
NAID
ISSN
1340-3478, 1880-3873
Year and Date
2018-06-01
Related Report
Peer Reviewed / Open Access
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