| Project/Area Number |
18K08130
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
木下 一郎 北海道大学, 大学病院, 教授 (40343008)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 肺腺癌 / 肺扁平上皮癌 / 非小細胞肺癌 / 肺癌 / 組織系 / Numb / Numbの機能 |
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| Outline of Final Research Achievements |
To investigate the role of Numb in tumorigenesis of lung adenocarcinoma and squamous cell carcinoma, we firstly performed loss-of-function and gain-of-function assays. Moreover, Numb expression was investigated in surgically resected lung adenocarcinoma and squamous cell carcinoma tissues by immunohistochemistry and correlations with prognosis were analyzed. Numb suppressed the proliferation, migration, and invasion of adenocarcinoma cells. In contrast, Numb promoted the proliferation, migration, and invasion of squamous cell carcinoma cells. High Numb expression was associated with favorable prognosis in patients with lung adenocarcinoma, but not in those with squamous cell carcinoma. Collectively, our data demonstrate that Numb plays distinct roles in lung adenocarcinoma and squamous cell carcinoma. In lung adenocarcinoma, Numb impairs tumor growth, whereas in lung squamous cell carcinoma it may promote proliferation.
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| Academic Significance and Societal Importance of the Research Achievements |
肺癌においてNumbの機能は腺癌と扁平上皮癌において違うことが示されたことからサブタイプ別に今後の治療を検討していく必要性が示された。腺癌においては腫瘍抑制的に機能しNumb高発現は予後良好であったことから腺癌においてNumbは予後予測因子となる可能性が示された。また扁平上皮癌においてはNumbは腫瘍増殖に機能しておりNumbを標的とした治療開発は今後の肺癌治療において学術的にも社会的にも意義があると考えられた。
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