Anti-angiogenic and lymphangiogenic therapy improves the tumor microenvironment and enhances the effectiveness of immunotherapy
| Project/Area Number |
18K08133
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | リンパ管 / がん免疫療法 / 血管 / 癌微小環境 / 腫瘍 / 壁側胸膜 / リンパ管新生阻害 / 血管新生阻害 / 免疫療法 / 抗腫瘍免疫療法 / 抗脈管療法 / 抗血管新生療法 / 抗リンパ管新生療法 |
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| Outline of Final Research Achievements |
In this study, we identified a previously unknown normal anatomy of lymphatics and blood vessels in the pleura covering the mouse chest wall and diaphragm. We immuno-stained the chest wall and diaphragm with markers for lymphatics and blood vessels. We observed and identified and their anatomy using a microscope.
Lymphatics include initial and collecting lymphatics. We identified their distribution in the pleura. We also confirmed the distribution of blood vessel networks of arteries, veins, and capillaries in the pleura. Next, we developed a disseminated metastatic mouse tumor model on the pleura of the chest wall and diaphragm. We immuno-stained this model with lymphatic and blood vessel markers. We were able to clearly observe the flowing out lymphatics and flowing in blood vessels of each tumor using a microscope. In this model, each tumor was small, and lymphangiogenesis and angiogenesis from the surrounding vasculatures to the tumor could be identified.
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| Academic Significance and Societal Importance of the Research Achievements |
癌や肺炎等の合併症に胸水貯留がある。胸水は肺を圧排し呼吸苦等を引き起こし患者さんの予後を悪化させる。胸水は胸膜の血管から産生されリンパ管から排出される。しかし、胸膜のリンパ管や血管の正常解剖、及び癌による病理学的変化はこれまで不明だった。本研究はこれらの不明な点を同定し、新規胸水対策の可能性を示した。また、本腫瘍モデルでは明瞭に脈管系を観察できるため、免疫細胞の腫瘍リンパ管や血管への分布を観察できる。癌免疫療法の効果を確認する際に、本モデルは腫瘍と脈管における免疫細胞の分布の確認を可能とした。
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Report
(5 results)
Research Products
(27 results)
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[Journal Article] Frequent Onsets of Cellulitis in Lower Limbs with Lymphedema Following COVID-19 mRNA Vaccination2022
Author(s)
51.Okazaki, T., Matashiro, M., Kodama, G., Tshubota, T., Furusawa, Y., and Izumi, S.
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Journal Title
Vaccines
Volume: 10
Issue: 4
Pages: 517-517
DOI
Related Report
Peer Reviewed
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[Journal Article] Beneficial effects of sunitinib on tumor microenvironment and immunotherapy targeting death receptor52018
Author(s)
Yoko Tsukita, Tatsuma Okazaki, Satoru Ebihara, Riyo Komatsu, Mayumi Nihei, Makoto Kobayashi, Taizou Hirano, Hisatoshi Sugiura, Tsutomu Tamada, Nobuyuki Tanaka, Yasufumi Sato, Hideo Yagita, Masakazu Ichinose
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Journal Title
OncoImmunology.
Volume: 8(2)
Issue: 2
Pages: 1543526-1543526
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Aspiration pneumonia induces muscle atrophy in the respiratory, skeletal, and swallowing systems.2018
Author(s)
Riyo Komatsu, Tatsuma Okazaki, Satoru Ebihara, Makoto Kobayashi, Yoko Tsukita, Mayumi Nihei, Hisatoshi Sugiura, Kaijun Niu, Takae Ebihara, Masakazu Ichinose.
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Journal Title
Journal of Cachexia, Sarcopenia and Muscle.
Volume: 9(4)
Issue: 4
Pages: 643653-643653
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Physical inactivity is associated with decreased growth differentiation factor 11 in chronic obstructive pulmonary disease2018
Author(s)
Rie Tanaka, Hisatoshi Sugiura, Mitsuhiro Yamada, Tomohiro Ichikawa, Akira Koarai, Naoya Fujino, Satoru Yanagisawa, Katsuhiro Onodera, Tadahisa Numakura, Kei Sato, Yorihiko Kyogoku, Hirohito Sano, Shun Yamanaka, Tatsuma Okazaki, Tsutomu Tamada, Motohiko Miura, Tsuneyuki Takahashi, Masakazu Ichinose
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Journal Title
Int J Chron Obstruct Pulmon Dis.
Volume: 13
Pages: 1333-1342
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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