Development of companion diagnostics for cancer immunotherapy

• Project/Area Number: 18K08143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Osaka University
• Principal Investigator: Iwahori Kota 大阪大学, 医学系研究科, 特任講師(常勤) (80566448)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: BiTE / T細胞 / コンパニオン診断薬 / がん免疫療法 / PD-1 / 肺癌 / リキッドバイオプシー / 肺がん

Outline of Final Research Achievements

In the present study, we evaluated detailed immunological aspects in clinical specimens from non-small cell lung cancer (NSCLC) patients. By using bispecific T-cell engager technology to assess the cytotoxicity of T cells, we found that the cytotoxicity of tumor-infiltrated T cells closely correlated with that of peripheral T cells. These results imply further applications to blood-based immune monitoring systems and predictive biomarkers for cancer immunotherapy.

Academic Significance and Societal Importance of the Research Achievements

本研究において末梢血T細胞活性測定法が腫瘍組織のT細胞機能の予測につながることが示唆されたことから、今後この測定法が免疫チェックポイント阻害薬の効果予測診断法として有用であることが示されれば、免疫チェックポイント阻害薬の効果がある患者さんを事前に予測して適切な治療を提供することにつながることが期待される。

Research Products

• [Journal Article] Immunotherapeutic potential of CD4 and CD8 single-positive T cells in thymic epithelial tumors (2020)
  • Author(s): Yoko Yamamoto, Kota Iwahori, Soichiro Funaki, Mitsunobu Matsumoto, Michinari Hirata, Tetsuya Yoshida, Ryu Kanzaki, Takashi Kanou, Naoko Ose, Masato Minami, Eiichi Sato, Atsushi Kumanogoh, Yasushi Shintani, Meinoshin Okumura, Hisashi Wada
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 4064-4064
  • DOI: 10.1038/s41598-020-61053-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cytotoxic CD8+ Lymphocytes in the Tumor Microenvironment (2020)
  • Author(s): Iwahori Kota
  • Journal Title: Advances in Experimental Medicine and Biology Volume: 1224 Pages: 53-62
  • DOI: 10.1007/978-3-030-35723-8_4
  • ISBN: 9783030357221, 9783030357238
  • Peer Reviewed
• [Journal Article] Peripheral T cell cytotoxicity predicts T cell function in the tumor microenvironment (2019)
  • Author(s): Iwahori Kota、Shintani Yasushi、Funaki Soichiro、Yamamoto Yoko、Matsumoto Mitsunobu、Yoshida Tetsuya、Morimoto-Okazawa Akiko、Kawashima Atsunari、Sato Eiichi、Gottschalk Stephen、Okumura Meinoshin、Kumanogoh Atsushi、Wada Hisashi
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 2636-2636
  • DOI: 10.1038/s41598-019-39345-5
  • Peer Reviewed / Open Access
• [Presentation] 末梢血T細胞活性測定による腫瘍免疫効果予測 (2018)
  • Author(s): 岩堀幸太、新谷康、舟木壮一郎、山本陽子、奥村明之進、熊ノ郷淳
  • Organizer: 第59回日本肺癌学会学術集会
• [Remarks] 抗PD-1抗体によるがん治療効果の予測につながる技術を開発
  • URL: http://resou.osaka-u.ac.jp/ja/research/2019/20190222_1