| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The purpose of this study was to search for novel diagnostic markers by comprehensive analysis of shedding substances in urine for detecting of early-stage squamous cell lung cancer. We identified several fragments (shedding substances) that were abnormally cleaved by excessive enzyme activity derived from cancer cells, and analyzed their clinical significance as tumor markers. We identified 58 candidate markers that met the criteria of ROC-AUC > 0.6 in urine from patients with lung squamous cell carcinoma. Analysis of urinary shedding material from separately collected lung squamous cell carcinomas identified shedding material X, with a molecular weight of approximately 1800, as a protein fragment that is upregulated in both early and advanced stage lung squamous cell carcinomas.
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