| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Polymorphism of cadherin-related family member (CDHR) 3 is associated with severe exacerbation of pediatric asthma, and CDHR3 is reported to be the receptor of rhinovirus (RV)-C which causes severe disease among RV. In addition, mutations in the CDHR3 gene lead to increased cell surface expression and increased the capacity of RV-C replication. Therefore, children with CDHR3 polymorphisms may be more susceptible to RV-C infection and severe asthma exacerbations.
This study revealed that CDHR3 directly activates eosinophils and neutrophils. Activation of eosinophils and neutrophils by CDHR3 may therefore be involved in the exacerbation of airway inflammation in asthma exacerbations.
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