| Project/Area Number |
18K08180
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Kagoshima University |
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Principal Investigator |
WATANABE Masaki 鹿児島大学, 医歯学総合研究科, 客員研究員 (90398298)
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| Co-Investigator(Kenkyū-buntansha) |
井上 博雅 鹿児島大学, 医歯学域医学系, 教授 (30264039)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 急性肺傷害 / 肺線維症 / ホスホリパーゼA2 / ロイコトリエンB4第二受容体 / 気管支喘息 / 間質性肺炎 / リゾリン脂質 |
|---|
| Outline of Final Research Achievements |
Secreted phospholipases A2 (Pla2) are enzymes that cleaves phospholipids into fatty acids and lysophospholipids. Focusing on Pla2 group ⅡD (Pla2g2d) and Leukotriene B4 receptor 2 (BLT2), we studied the potential role in pathogenesis of acute lung injury (ALI) and pulmonary fibrosis (PF). We conclude that BL2 suppresses ALI. Interestingly, Pla2g2d enhances PF in early phase, but plays a protective role against PF in late phase.
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| Academic Significance and Societal Importance of the Research Achievements |
難治性呼吸器疾患である急性肺傷害および肺線維症は、詳細な病態機序は不明であり、有効な治療法が確立されていないため、予後は極めて不良である。本研究により、両者の病態におけるⅡD型ホスホリパーゼA2とロイコトリエンB4第二受容体の役割が明らかになった。これまでにない新しい観点に基づく病態理解および新規治療法の開発につながる。
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