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The identification and assessment of novel disease related gene for pulmonary hypertension

Research Project

Project/Area Number 18K08183
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Tamura Yuichi  国際医療福祉大学, 医学部, 教授 (00468498)

Project Period (FY) 2018-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肺高血圧症 / 疾患関連遺伝子 / 肺動脈性肺高血圧症
Outline of Final Research Achievements

The aim of this study was to identify novel causative genes involved in the pathogenesis of pulmonary arterial hypertension (PAH) and to link them to curative therapies. In this study, we comprehensively analyzed PDE1A-related genetic variants and their clinical impact.
To conduct a comprehensive analysis of the PDE1A gene, we established an analysis method using Nanopore technology, a new-generation sequencer that can customize long reads, and conducted the analysis. The results of this analysis suggest that patients with PDE1A mutations are more responsive to PDE-5 inhibitor therapy than those with PDE1A mutations.

Academic Significance and Societal Importance of the Research Achievements

本研究は、従来の遺伝子変異の知見では説明しきれない遺伝的背景を新規に同定する目的で着手した。本邦におけるGWAS解析の結果、PAHにおける新たな疾患関連遺伝子PDE1Aが同定された。PDEファミリーは特にPDE5が肺高血圧症の発症に深く関与されていることが知られており、PDE1AもヒトのPAHにおいて関与していることを明らかにした。本研究においてPDE1Aのプロモーター領域における変異を同定し、それが治療反応性に関与していることが明らかになったことから、治療介入の方法が遺伝子変異によって異なる可能性が期待され、いわゆるprecision medicineにつながることが期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (63 results)

All 2022 2021 2020 2019 2018

All Journal Article (21 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 21 results,  Open Access: 16 results) Presentation (40 results) (of which Int'l Joint Research: 6 results,  Invited: 31 results) Book (2 results)

  • [Journal Article] Long‐term safety of a structured transition protocol from parenteral prostanoids to selexipag in pulmonary arterial hypertension2022

    • Author(s)
      Tamura Yuichi、Furukawa Asuka、Tamura Yudai、Yamada Kenta、Taniguchi Hirohisa、Fukuda Keiichi、Kawamura Akio、Satoh Toru
    • Journal Title

      Pulmonary Circulation

      Volume: 12 Issue: 1

    • DOI

      10.1002/pul2.12058

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multi-Institutional Prospective Cohort Study of Patients With Pulmonary Hypertension Associated With Respiratory Diseases2021

    • Author(s)
      Tanabe N、Kumamaru H、Tamura Y、Taniguchi Hi、Emoto N、Yamada Y、Nishiyama O、Tsujino I、Kuraishi H、Nishimura Y、Kimura H、Inoue Y、Morio Y、Nakatsumi Y、Satoh T、Hanaoka M、Kusaka K、Sumitani M、Handa T、Sakao S、Kimura T、Kondoh Y、Nakayama K、Tanaka K、Ohira H、Nishimura M、Miyata H、Tatsumi K、for the JRPHS Group
    • Journal Title

      Circulation Journal

      Volume: 85 Issue: 4 Pages: 333-342

    • DOI

      10.1253/circj.CJ-20-0939

    • NAID

      130008003051

    • ISSN
      1346-9843, 1347-4820
    • Year and Date
      2021-03-25
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictors of hypoxemia in type-B acute aortic syndrome: a retrospective study2021

    • Author(s)
      Tamura Yudai、Tamura Yuichi、Kametani Motoko、Minami Yoshiaki、Nakayama Tomoko、Takagi Daisuke、Unoki Takashi、Yamamuro Megumi、Kawamura Akio、Sakamoto Tomohiro、Sawamura Tadashi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1

    • DOI

      10.1038/s41598-021-02886-9

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrocardiographic Manifestations of Immune Checkpoint Inhibitor Myocarditis2021

    • Author(s)
      Power John R.、Alexandre Joachim、Choudhary Arrush、Ozbay Benay、Hayek Salim、Asnani Aarti、Tamura Yuichi、Aras Mandar、Cautela Jennifer、Thuny Franck、Gilstrap Lauren、Arangalage Dimitri、Ewer Steven、Huang Shi、Deswal Anita、Palaskas Nicolas L.、Finke Daniel、Lehmann Lorenz、Ederhy Stephane、Moslehi Javid、
    • Journal Title

      Circulation

      Volume: 144 Issue: 18 Pages: 1521-1523

    • DOI

      10.1161/circulationaha.121.055816

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Liver fibrosis index as a novel prognostic factor in patients with pulmonary arterial hypertension2021

    • Author(s)
      Furukawa Asuka、Tamura Yuichi、Yamada Kenta、Taniguchi Hirohisa、Ohashi Narutaka、Okabe Teruo、Kawamura Akio
    • Journal Title

      Heart and Vessels

      Volume: 37 Issue: 4 Pages: 601-608

    • DOI

      10.1007/s00380-021-01951-7

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of left ventricular pacing performance among pre-shaped guidewires designed for transfemoral-approach transcatheter aortic valve implantation2021

    • Author(s)
      Tamura Yudai、Tamura Yuichi、Konami Yutaka、Suzuyama Hiroto、Horio Eiji、Yamada Masahiro、Sassa Toshiharu、Taguchi Eiji、Horibata Yoko、Ideta Ichiro、Kawamura Akio、Sakamoto Tomohiro
    • Journal Title

      Heart and Vessels

      Volume: 37 Issue: 3 Pages: 460-466

    • DOI

      10.1007/s00380-021-01938-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Explainable Artificial Intelligence Model for Diagnosis of Atrial Fibrillation Using Holter Electrocardiogram Waveforms2021

    • Author(s)
      Taniguchi Hirohisa、Takata Tomohiro、Takechi Mineki、Furukawa Asuka、Iwasawa Jin、Kawamura Akio、Taniguchi Tadahiro、Tamura Yuichi
    • Journal Title

      International Heart Journal

      Volume: 62 Issue: 3 Pages: 534-539

    • DOI

      10.1536/ihj.21-094

    • NAID

      130008045618

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case Report: BMPR2-Targeted MinION Sequencing as a Tool for Genetic Analysis in Patients With Pulmonary Arterial Hypertension2021

    • Author(s)
      Takashima Tomoya、Brisset Sophie、Furukawa Asuka、Taniguchi Hirohisa、Takeyasu Rika、Kawamura Akio、Tamura Yuichi
    • Journal Title

      Frontiers in Cardiovascular Medicine

      Volume: 8

    • DOI

      10.3389/fcvm.2021.711694

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pulmonary hypertension associated with neurofibromatosis type 22021

    • Author(s)
      Taniguchi Hirohisa、Takashima Tomoya、Tu Ly、Thuillet Rapha?l、Furukawa Asuka、Furukawa Yoshiko、Kawamura Akio、Humbert Marc、Guignabert Christophe、Tamura Yuichi
    • Journal Title

      Pulmonary Circulation

      Volume: 11 Issue: 3 Pages: 1-4

    • DOI

      10.1177/20458940211029550

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improvements in French risk stratification score were correlated with reductions in mean pulmonary artery pressure in pulmonary arterial hypertension: a subanalysis of the Japan Pulmonary Hypertension Registry (JAPHR)2021

    • Author(s)
      Tamura Yuichi、the Japan Pulmonary Hypertension Registry (JAPHR) Network、Kumamaru Hiraku、Abe Kohtaro、Satoh Toru、Miyata Hiroaki、Ogawa Aiko、Tanabe Nobuhiro、Hatano Masaru、Yao Atsushi、Tsujino Ichizo、Fukuda Keiichi、Kimura Hiroshi、Kuwana Masataka、Matsubara Hiromi、Tatsumi Koichiro
    • Journal Title

      BMC Pulmonary Medicine

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12890-021-01398-6

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum and Pulmonary Uric Acid in Pulmonary Arterial Hypertension2021

    • Author(s)
      Savale L、Akagi S、Tu L、Cumont A、Thuillet R、Phan C、Le Vely B、Berrebeh N、Huertas A、Jais X、Cottin V、Chaouat A、Tromeur C、Boucly A、Jutant Etienne M、Mercier O、Fadel E、Montani D、Sitbon O、Humbert M、Tamura Y、Guignabert C
    • Journal Title

      European Respiratory Journal

      Volume: 57 Issue: 2 Pages: 2000332-2000332

    • DOI

      10.1183/13993003.00332-2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] How COVID-19 Affected the Introduction of Telemedicine and Patient Reported Outcomes Among Patients With Pulmonary Hypertension ― A Report From a Referral Center in Japan ―2020

    • Author(s)
      Tamura Yuichi、Takeyasu Rika、Furukawa Asuka、Takada Hiromi、Takechi Mineki、Taniguchi Hirohisa、Kawamura Akio
    • Journal Title

      Circulation Reports

      Volume: 2 Issue: 9 Pages: 526-530

    • DOI

      10.1253/circrep.CR-20-0088

    • NAID

      130007899901

    • ISSN
      2434-0790
    • Year and Date
      2020-09-10
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Psychometric Validation of a Japanese Version of the emPHasis-10 Questionnaire, a Patient-Reported Outcome Measure for Pulmonary Hypertension ― Multicenter Study in Japan ―2020

    • Author(s)
      Takeyasu Rika、Tamura Yuichi、Abe Kohtaro、Goda Ayumi、Satoh Toru、Suda Rika、Tanabe Nobuhiro、Tsujino Ichizo、Yamazaki Tsutomu、Tatsumi Koichiro
    • Journal Title

      Circulation Reports

      Volume: 2 Issue: 4 Pages: 255-259

    • DOI

      10.1253/circrep.CR-20-0014

    • NAID

      130007830862

    • ISSN
      2434-0790
    • Year and Date
      2020-04-10
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pulmonary Artery Pressure as a Treatment Target to Improve the Prognosis of Idiopathic Pulmonary Arterial Hypertension ― Insight From a Cohort From Two Japanese Pulmonary Hypertension Centers ―2020

    • Author(s)
      Ishiguro Midori、Takeuchi Kaori、Kikuchi Hanako、Goda Ayumi、Inami Takumi、Tamura Yuichi、Kataoka Masaharu、Fukuda Keiichi、Satoh Toru
    • Journal Title

      Circulation Reports

      Volume: 2 Issue: 4 Pages: 249-254

    • DOI

      10.1253/circrep.CR-20-0006

    • NAID

      130007832337

    • ISSN
      2434-0790
    • Year and Date
      2020-04-10
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An anti-RNA polymerase III antibody-positive systemic sclerosis patient with thymic carcinoma whose digital ulcers healed during treatment with macitentan and sildenafil for pulmonary arterial hypertension2020

    • Author(s)
      Takaoka Mariko、Takekoshi Tomonori、Nakajima Rina、Furukawa Asuka、Tamura Yuichi、Shirai Yuichiro、Furuya Yoshiaki、Nagase Seisuke、Hayashi Aeru
    • Journal Title

      European Journal of Dermatology

      Volume: 30 Issue: 2 Pages: 207-209

    • DOI

      10.1684/ejd.2020.3747

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A high BNP level predicts an improvement in exercise tolerance after a successful catheter ablation of persistent atrial fibrillation.2019

    • Author(s)
      Katsumata Y, Tamura Y, Kimura T, Kohsaka S, Sadahiro T, Nishiyama T, Aizawa Y, Azuma K, Fukuda K, Takatsuki S.
    • Journal Title

      J Cardiovasc Electrophysiol.

      Volume: 30 Issue: 11 Pages: 2283-2290

    • DOI

      10.1111/jce.14149

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adverse events in patients with ulcerative colitis treated with indigo naturalis: a Japanese nationwide survey2019

    • Author(s)
      Naganuma M, Sugioto S, Suzuki H, Matsuno Y, Araki T, Shimizu H, Hayashi R, Fukuda T, Nakamoto N, Iijima H, Nakamura S, Kataoka M, Tamura Y, Tatsumi K, Hibi T, Suzuki Y, Kani T, INDIGO survey Group
    • Journal Title

      J Gastroenterol

      Volume: 54(10) Issue: 10 Pages: 891-896

    • DOI

      10.1007/s00535-019-01591-9

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fos-related antigen-1 transgenic mouse as a model for systemic sclerosis: A potential role of M2 polarization2019

    • Author(s)
      Yasuoka H, Yuen Yu Angela Tam, Okazaki Y, Tamura Y, Matsuo K, Carol Feghali-Bostwick, Takeuchi T, Kuwana M
    • Journal Title

      J Scleroderma Relat Disord

      Volume: 4(2) Issue: 2 Pages: 137-148

    • DOI

      10.1177/2397198319838140

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Risk stratification and medical therapy of pulmonary arterial hypertension2019

    • Author(s)
      Galie N, Channick RN, Frantz RP, Grunig E, Jing ZC, Moiseeva O, Preston IR, Pulido T, Safdar Z, Tamura Y, McLaughlin VV
    • Journal Title

      Eur Respir J

      Volume: 53(1) Issue: 1 Pages: 1801889-1801889

    • DOI

      10.1183/13993003.01889-2018

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Balloon pulmonary angioplasty for chronic thromboembolic pulmonary hypertension: A systematic review2018

    • Author(s)
      Tanabe Nobuhiro、Kawakami Takashi、Satoh Toru、Matsubara Hiromi、Nakanishi Norifumi、Ogino Hitoshi、Tamura Yuichi、Tsujino Ichizo、Ogawa Aiko、Sakao Seiichiro、Nishizaki Mari、Ishida Keiichi、Ichimura Yasunori、Yoshida Masahiro、Tatsumi Koichiro
    • Journal Title

      Respiratory Investigation

      Volume: 56 Issue: 4 Pages: 332-341

    • DOI

      10.1016/j.resinv.2018.03.004

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension2018

    • Author(s)
      Tamura Yuichi, Phan Carole, Tu Ly, Le Hiress Morane, Thuillet Raphael, Jutant Etienne-Marie, Fadel Elie, Savale Laurent, Huertas Alice, Humbert Marc, Guignabert Christophe
    • Journal Title

      Journal of Clinical Investigation

      Volume: 128(5) Issue: 5 Pages: 1956-1970

    • DOI

      10.1172/jci96462

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Yes, pulmonary hypertension should be extensively treated before ASD occlusion.2020

    • Author(s)
      田村雄一
    • Organizer
      第84回日本循環器学会会学術集会・Asian Pacific Society of Cardiology Congress 2020 (APSC2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Recent advances in PAH therapy from Japanese PH registry2020

    • Author(s)
      田村雄一
    • Organizer
      第84回日本循環器学会学術集会・Asian Pacific Society of Cardiology Congress 2020 (APSC2020)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 難病:肺高血圧のIT管理 (IT-based care for rare disease patients (Pulmonary hypertension)2020

    • Author(s)
      田村雄一
    • Organizer
      日本遠隔医療学会スプリングカンファレンス2020
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] CIN事業を活用して加速化する肺高血圧症患者レジストリ:JAPHR (CIN accelerate JAPHR: Japanese national Registry for pulmonary hypertension)2019

    • Author(s)
      田村雄一
    • Organizer
      第1回国際レジストリフォーラム
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Recent perspective of risk stratification and PH registry-message from JAPAN.2019

    • Author(s)
      田村雄一
    • Organizer
      2019 JPCPHS-TPHS Joint PH Forum
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 肺高血圧症の診断治療を基礎からもう一度考える2019

    • Author(s)
      田村雄一
    • Organizer
      第60回日本脈管学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 肺高血圧のIT管理(IT Solutions for Pulmonary Hypertension Patient Care)2019

    • Author(s)
      田村雄一
    • Organizer
      第23回日本心不全学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 循環器医師から見た糖尿病管理と腫瘍循環器外来 ~DPP-4阻害薬/SGLT2阻害薬の展望~2019

    • Author(s)
      田村雄一
    • Organizer
      第2回 日本腫瘍循環器学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 運動時VTを起こした一例2019

    • Author(s)
      田村雄一
    • Organizer
      第67回日本心臓病学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Japan PH Registry におけるFrench Risk Stratification Score の解析2019

    • Author(s)
      田村雄一
    • Organizer
      第67回日本心臓病学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] ニースシンポジウム2018及びレジストリ―をふまえた肺高血圧症の最新の知見2019

    • Author(s)
      田村雄一
    • Organizer
      第67回日本心臓病学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 遠隔診療を用いた難病肺高血圧症診療「どこでも専門医:NAPTEC」の試み2019

    • Author(s)
      田村雄一
    • Organizer
      第67回日本心臓病学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] PH道場2019 道場入門心得2019

    • Author(s)
      田村雄一
    • Organizer
      第4回日本肺高血圧・肺循環学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 会長特別企画:肺高血圧症治療の未来を拓く2019

    • Author(s)
      田村雄一
    • Organizer
      第4回日本肺高血圧・肺循環学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 本邦における肺高血圧症患者レジストリの構築と、それを活用したトランスレーショナルリサーチの展開2019

    • Author(s)
      田村雄一
    • Organizer
      第4回日本肺高血圧・肺循環学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 未来志向のAll Japan PH 患者レジストリ:Japan PH Registry2019

    • Author(s)
      田村雄一
    • Organizer
      第4回日本肺高血圧・肺循環学会学術集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] AIを用いたホルター心電図自動解析システムの構築. 第39回日本ホルター・ノンインベイシブ心電学研究会 第34回心電情報処理ワークショップ2019

    • Author(s)
      田村雄一
    • Organizer
      第29回体表心臓微小電位研究会 第16回心電図伝送システム研究会 合同集会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 左室駆出率の保たれた心不全2019

    • Author(s)
      田村雄一
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] 肺高血圧の診断治療を基礎からもう一度考える2019

    • Author(s)
      田村雄一
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] The contribution of inflammation in pathobiology of PAH2019

    • Author(s)
      田村雄一
    • Organizer
      第59回日本呼吸器学会学術講演会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] The Insights from Japan PH Registry: Risk Assessments and Perspectives.2019

    • Author(s)
      Tamura Y
    • Organizer
      第83回日本循環器学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 診療科連携病病連携から肺高血圧の診断治療を基礎からもう一度考える2018

    • Author(s)
      田村雄一
    • Organizer
      第28回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ハートシンポジウムにおける「心不全・肺高血圧症の遠隔モニタリング」2018

    • Author(s)
      田村雄一
    • Organizer
      第22回日本心不全学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Uric acid contributes to the progression of pulmonary hypertension in rodents and humans2018

    • Author(s)
      Laurent Savale, Satoshi Akagi, Ly Tu, Raphael Thuillet, Jennifer Bordenave, Thimote Quatremare, Amelie Cumont, Carole Phan, Alice Hueretas, Marc Humbert, Yuichi Tamura, Christope Guignabert.
    • Organizer
      ERS International Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] PGI2系薬剤:注射製剤のタイトレーションのコツ2018

    • Author(s)
      田村雄一
    • Organizer
      第66回日本心臓病学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 左室駆出率が低下していない心不全症例2018

    • Author(s)
      田村雄一
    • Organizer
      第66回日本心臓病学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] PAH Treatment in Japan.2018

    • Author(s)
      Tamura Y
    • Organizer
      8th International Critical Care Congress
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 2015 ESC/ERS Guidelinesからみた最新の肺高血圧症診療2018

    • Author(s)
      田村雄一
    • Organizer
      第54回日本小児循環器学会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 遠隔医療と他領域連携で挑む循環器診療の最前線2018

    • Author(s)
      田村雄一
    • Organizer
      第54回日本小児循環器学会総会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 膠原病(CTD)に伴う軽症肺動脈性肺高血圧症に対する介入試験2018

    • Author(s)
      安岡秀剛、白井悠一郎、田村雄一、川口鎮司、天野宏一、岡田正人、桑名正隆
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 周術期に非経口PGI2製剤製剤を導入しAVRを施行し得たHPAHの一例2018

    • Author(s)
      古川明日香、田村雄一、山田健太、谷口浩久、岩堀浩也、大橋成孝、岡部輝雄、河村朗夫
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 早期非経口PGI2介入による血行動態改善の重要性を示すIPAHの一例2018

    • Author(s)
      古川明日香、田村雄一、山田健太、谷口浩久、岩堀浩也、大橋成孝、岡部輝雄、河村朗夫
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] ポスト・Nice2018におけるPDE5阻害薬の位置づけ2018

    • Author(s)
      田村雄一
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Overview ~0からキャッチアップするPH基礎研究~2018

    • Author(s)
      田村雄一
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 青黛投与に伴う肺動脈性肺高血圧症の特徴2018

    • Author(s)
      田村雄一
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] PAHにおける心肝連関と新規予後因子となる肝線維化マーカーLFIの検討2018

    • Author(s)
      古川明日香、田村雄一、山田健太、谷口浩久、岩堀浩也、大橋成孝、岡部輝雄、河村朗夫
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] 新しいリスク分類に基づいた治療アルゴリズムの変更について~Say Good-bye to WHO-FC~2018

    • Author(s)
      田村雄一
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] 神経線維腫症2型(NF2)に合併した肺高血圧症の一例2018

    • Author(s)
      谷口浩久、田村雄一、古川明日香、山田健太、岩堀浩也、大橋成孝、古川佳子、岡部輝雄、河村朗夫
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] The perspective of the PH registry in Japan.2018

    • Author(s)
      Japan-Korea Joint Symposium, Tamura Y
    • Organizer
      第3回日本肺高血圧症・肺循環学会学術集会
    • Related Report
      2018 Research-status Report
    • Invited
  • [Presentation] Current Perspective treatment of CTD associated PH in Japan.2018

    • Author(s)
      Tamura Y
    • Organizer
      Asian Pacific Society of Cardiology Congress 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 奇脈、深部静脈血栓の原因、肺高血圧症の原因. 今日の問診票/診断辞典 デジタル電子版(Current Decision Support/CDS)2020

    • Author(s)
      田村雄一
    • Publisher
      株式会社プレシジョン
    • Related Report
      2019 Research-status Report
  • [Book] ベッドサイドで使える腫瘍循環器入門 ~循環器医と腫瘍専門医が知っておくべき20の基本知識~2019

    • Author(s)
      田村雄一
    • Total Pages
      168
    • Publisher
      中外医学社
    • ISBN
      9784498134386
    • Related Report
      2019 Research-status Report

URL: 

Published: 2018-04-23   Modified: 2023-01-30  

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