Emotional neural network and its association with reduced physical activity in COPD

• Project/Area Number: 18K08186
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Showa University
• Principal Investigator: IZUMIZAKI Masahiko 昭和大学, 医学部, 教授 (20398697)
• Co-Investigator(Kenkyū-buntansha): 政岡 ゆり 昭和大学, 医学部, 准教授 (70398692) ; 吉川 輝 昭和大学, 保健医療学部, 講師 (90737355)
• Project Period (FY): 2018-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2020: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2019: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: COPD / 機能的磁気共鳴画像 / 接続性解析 / うつ病傾向 / 呼吸困難 / 海馬傍回 / 認知機能 / 海馬歯状回 / 情動 / 脳領域活動性 / 辺縁系 / 海馬 / 扁桃体 / 脳領域結合性 / 慢性閉塞性肺疾患 / fMRI / 神経ネットワーク

Outline of Final Research Achievements

We employed resting-state fMRI to analyze brain functional connectivity (FC) and MRI to measure regional brain volumes in COPD patients and healthy elderly individuals. Our resting-state fMRI results suggest that COPD patients experience alterations in brain networks, as evidenced by decreased FC between the left hippocampus and the right sensorimotor region, as well as between the left and right hippocampi. Path analysis to explore the relationships among respiratory function, regional brain volumes, and psychiatric tendencies revealed that in COPD patients, the model with the highest goodness of fit indicated that a decline in %FEV1 was associated with increased depressive tendencies. This association was mediated by decreases in the volume of the genu of the corpus callosum. These findings suggest that as COPD progresses, atrophy of the genu of the corpus callosum may lead to decreased interhemispheric communication, potentially contributing to a rise in depressive tendencies.

Academic Significance and Societal Importance of the Research Achievements

本研究は、COPDにおける中枢疾患の発症リスクに関する新たな知見を提供するものである。安静時fMRIを用いてCOPD患者の脳内ネットワークの変化を明らかにし、海馬と他の脳領域との機能的接続性の低下が生じていることを示した。さらに、気流閉塞の進展とうつ病傾向の悪化の関係には、脳梁膝部の萎縮が介在することを見出した。これらの知見は、COPDにおける中枢疾患の発症メカニズムの理解を深め、新たな治療アプローチの開発に貢献することが期待される。また、早期発見・早期介入による合併症予防と適切な疾患管理につながる可能性がある。

Research Products

• [Journal Article] Role of the amygdala‐medial orbitofrontal relationship in odor recognition in the elderly (2023)
  • Author(s): Sakikawa Kei、Masaoka Yuri、Honma Motoyasu、Yoshikawa Akira、Yoshida Masaki、Kamimura Sawa、Ida Masahiro、Kobayashi Hitome、Izumizaki Masahiko
  • Journal Title: Brain and Behavior Volume: 13 Issue: 4
  • DOI: 10.1002/brb3.2956
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative state anxiety predicts postoperative health-related quality of life: A prospective observational study on patients undergoing lung cancer surgery (2023)
  • Author(s): Takamiya Shinnosuke、Honma Motoyasu、Masaoka Yuri、Okada Momoka、Ohashi Shinichi、Tanaka Yoko、Suzuki Kosuke、Uematsu Shugo、Kitami Akihiko、Izumizaki Masahiko
  • Journal Title: Frontiers in Psychology Volume: 14
  • DOI: 10.3389/fpsyg.2023.1161333
  • Peer Reviewed / Open Access
• [Journal Article] New granule cells in the olfactory bulb are associated with high respiratory input in an enriched odor environment (2022)
  • Author(s): Kamimura Sawa、Masaoka Yuri、Yoshikawa Akira、Kamijo Shotaro、Ohtaki Hirokazu、Koiwa Nobuyoshi、Honma Motoyasu、Sakikawa Kei、Kobayashi Hitome、Izumizaki Masahiko
  • Journal Title: Neuroscience Research Volume: 182 Pages: 52-59
  • DOI: 10.1016/j.neures.2022.05.007
  • Peer Reviewed / Open Access
• [Journal Article] Reading on a smartphone affects sigh generation, brain activity, and comprehension (2022)
  • Author(s): Honma Motoyasu、Masaoka Yuri、Iizuka Natsuko、Wada Sayaka、Kamimura Sawa、Yoshikawa Akira、Moriya Rika、Kamijo Shotaro、Izumizaki Masahiko
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 1589-1589
  • DOI: 10.1038/s41598-022-05605-0
  • Peer Reviewed / Open Access
• [Journal Article] Entorhinal cortex and parahippocampus volume reductions impact olfactory decline in aged subjects (2021)
  • Author(s): izuka N, Masaoka Y, Kubota S, Sugiyama H, Yoshida M, Yoshikawa A, Koiwa N, Honma M, Watanabe K, Kamijo S, Kamimura S, Ida M, Ono K, Izumizaki M.
  • Journal Title: Brain and Behavior Volume: 11 Issue: 5
  • DOI: 10.1002/brb3.2115
  • Peer Reviewed / Open Access
• [Journal Article] Volume of the right supramarginal gyrus is associated with a maintenance of emotion recognition ability (2021)
  • Author(s): Wada Sayaka、Honma Motoyasu、Masaoka Yuri、Yoshida Masaki、Koiwa Nobuyoshi、Sugiyama Haruko、Iizuka Natsuko、Kubota Satomi、Kokudai Yumika、Yoshikawa Akira、Kamijo Shotaro、Kamimura Sawa、Ida Masahiro、Ono Kenjiro、Onda Hidetoshi、Izumizaki Masahiko
  • Journal Title: PLOS ONE Volume: 16 Issue: 7 Pages: e0254623-e0254623
  • DOI: 10.1371/journal.pone.0254623
  • Peer Reviewed / Open Access
• [Journal Article] Cascade process mediated by left hippocampus and left superior frontal gyrus affects relationship between aging and cognitive dysfunction (2021)
  • Author(s): Kokudai Yumika、Honma Motoyasu、Masaoka Yuri、Yoshida Masaki、Sugiyama Haruko、Yoshikawa Akira、Koiwa Nobuyoshi、Kubota Satomi、Iizuka Natsuko、Wada Sayaka、Kamijo Shotaro、Uchida Yuki、Yano Satoshi、Ida Masahiro、Ono Kenjiro、Izumizaki Masahiko
  • Journal Title: BMC Neuroscience Volume: 22 Issue: 1 Pages: 75-75
  • DOI: 10.1186/s12868-021-00680-x
  • Peer Reviewed / Open Access
• [Journal Article] Heart Rate and Respiration Affect the Functional Connectivity of Default Mode Network in Resting-State Functional Magnetic Resonance Imaging (2020)
  • Author(s): Yoshikawa Akira、Masaoka Yuri、Yoshida Masaki、Koiwa Nobuyoshi、Honma Motoyasu、Watanabe Keiko、Kubota Satomi、Natsuko Iizuka、Ida Masahiro、Izumizaki Masahiko
  • Journal Title: Frontiers in Neuroscience Volume: 14 Pages: 631-631
  • DOI: 10.3389/fnins.2020.00631
  • Peer Reviewed / Open Access
• [Journal Article] Hippocampus and Parahippocampus Volume Reduction Associated With Impaired Olfactory Abilities in Subjects Without Evidence of Cognitive Decline (2020)
  • Author(s): Kubota Satomi、Masaoka Yuri、Sugiyama Haruko、Yoshida Masaki、Yoshikawa Akira、Koiwa Nobuyoshi、Honma Motoyasu、Kinno Ryuta、Watanabe Keiko、Iizuka Natsuko、Ida Masahiro、Ono Kenjiro、Izumizaki Masahiko
  • Journal Title: Frontiers in Human Neuroscience Volume: 14 Pages: 556519-556519
  • DOI: 10.3389/fnhum.2020.556519
  • Peer Reviewed / Open Access
• [Presentation] Odor associated with memory-recalling could be a preventive method for cognitive impairment: investigating in human and animal studies. (2023)
  • Author(s): Masaoka, Y., Yoshikawa, A., Kamimura, S., Ohtaki, H., Honma, M., Sakikawa, K., Kamijo, S., Yoshida, M., Izumizaki, M.
  • Organizer: 第100回日本生理学会大会
• [Presentation] Resting-state fMRI connectivity analysis on psychiatric symptoms for COPD patients. (2023)
  • Author(s): Yoshikawa, A., Masaoka, Y., Yoshida, M., Koiwa, N., Ryo, M., Kubota, S., iizuka, N., Honma, M., Kamijo, S., Ida, M., Izumizaki, M.
  • Organizer: 第100回日本生理学会大会
• [Presentation] 嗅覚刺激を用いた脳機能トレーニング法の創出 (2022)
  • Author(s): 政岡ゆり、本間元康、泉﨑雅彦
  • Organizer: 第11回日本情動学・第１回看護ケアサイエンス学会合同大会
• [Presentation] New granule cells in the olfactory bulb are associated with high respiratory input in an enriched odor environment. (2022)
  • Author(s): Masaoka, Y., Kamimura, S., Yoshikawa, A., Kamijo, S., Ohtaki, H., Koiwa, N., Honma, M., Sakikawa, K., Kobayashi, H., Izumizaki, M.
  • Organizer: 第45回日本神経科学大会
• [Presentation] 豊かな嗅覚環境と嗅球と海馬の神経再生 (2022)
  • Author(s): 政岡ゆり、上村佐和、吉川輝、上條翔太郎、大滝博和、小岩信義、本間元康、﨑川慶、小林一女、泉﨑雅彦
  • Organizer: 第25回アロマテラピー学会
• [Presentation] 嗅覚における辺縁系と前頭葉の機能的相互作用の検討 (2022)
  • Author(s): 﨑川慶、政岡ゆり、本間元康、吉田正樹、吉川輝、上條翔太郎、上村佐和、小林一女、泉﨑雅彦
  • Organizer: 第25回アロマテラピー学会
• [Presentation] Functional interaction between the limbic system and the frontal regions could play a significant role in olfactory recognition. (2022)
  • Author(s): Sakikawa, K., Masaoka, Y., Honma, M., Yoshida, M., Yoshikawa, A., Kamijo, S., Kamimura, S., Kobayashi, H., Izumizaki, M.
  • Organizer: 第99回日本生理学会大会
• [Presentation] The activation of the fusiform gyrus associated with odor-induced autographical memory: reminding some familiar faces? (2021)
  • Author(s): Masaoka, Y., Sugiyama, H., Watanabe, K., Kubota, S., Yoshida, M., Yoshikawa, A., Koiwa, N., Honma, M., Iiduka, N., Honma, M., Ida, M., Ono, K., Izumizaki, M.
  • Organizer: 第44回日本神経科学会
• [Presentation] Resting-State fMRI Connectivity Analysis between Hippocampus and Motor area in COPD patients. (2020)
  • Author(s): Yoshikawa, A., Masaoka, Y., Yoshida, M., Koiwa, N., Iizuka, N., Kubota, S., Manabe, R., Ida, M., Izumizaki, M.
  • Organizer: 第97回日本生理学会大会
• [Presentation] Parahippocampus volume changes provide an early indication of declining of olfactory ability and cognitive function in elderly subjects. (2020)
  • Author(s): Masaoka, Y., Kubota, S., Sugiyama, H., Yoshida, M., Yoshikawa, A., Koiwa, N., Honma, M., Kinnno, R., Iiduka, N., Ida, M., Ono, K., Izumizaki, M.
  • Organizer: 第97回日本生理学会大会
• [Presentation] Declining of olfactory ability and volumes of hippocampus subfields in elderly subjects. (2020)
  • Author(s): Iizuka, N., Masaoka, Y., Ida, M., Yoshida, M., Yoshikawa, A., Koiwa, N., Kubota, S., Honma, M., Kokudai, Y., Wada, S., Ono, K., Izumizaki, M.
  • Organizer: 第97回日本生理学会大会
• [Presentation] Hippocampus abnormalities evaluated by density imaging in COPD patients. (2019)
  • Author(s): Iizuka, N., Masaoka, Y., Manabe, R., Yoshida, M.,Kamagata, K., Takenaka, Y., Okuda, K., ., Yoshikawa, A., Kubota, S., Ida, M., Ono, K., Izumizaki, M.
  • Organizer: The 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research
• [Presentation] Relation between resting-state functional connectivity and cognitive function. (2019)
  • Author(s): Yoshikawa, A., Masaoka, Y., Yoshida, M., Koiwa, N., Kubota, S., Manabe, R., Iizuka, N., Ida, M., Izumizaki, M.
  • Organizer: The 96th Annual Meeting of the Physiological Society of Japan
  • Int'l Joint Research
• [Presentation] Measurements of hippocampus subfield volumes in chronic obstructive pulmonary disease patients. (2019)
  • Author(s): Iizuka, N., Masaoka, Y., Ida, M., Manabe, R., Yoshida, M.,, Yoshikawa, Ak, Koiwa, N., Kubota, S., Honma, M., Ono, K., Izumizaki, M.
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] Hippocampus abnormalities evaluated by microstructure imaging in patients with chronic obstructive respiratory disease. (2019)
  • Author(s): Iizuka, N., Masaoka, Y., Yoshida, M.,, Manabe, R., Kamagata, K., Okuda, K., Yoshikawa, A., Ida, M., Izumizaki, M.
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] Network analysis of functional brain connectivity between hippocampus and motor area in COPD patient. (2019)
  • Author(s): Yoshikawa, A., Ida, M., Masaoka, Y., Yoshida, M., Koiwa, N., Kubota, S., Manabe, R., Honma, M., Iizuka, N., Izumizaki, M.
  • Organizer: 第47回日本磁気共鳴医学会大会
• [Presentation] Relation between resting-state functional connectivity and cognitive function. (2019)
  • Author(s): Yoshikawa, A., Masaoka, Y., Yoshida, M., Koiwa, N., Kubota, S., Manabe, R., Iizuka, N., Ida, M., Izumizaki, M.
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] Hippocampus abnormalities evaluated by density imaging in COPD patients. (2019)
  • Author(s): Iizuka, N., Masaoka, Y., Manabe, R., Yoshida, M.,Kamagata, K., Takenaka, Y., Okuda, K., Yoshikawa, A., Kubota, S., Ida, M., Ono, K., Izumizaki, M.
  • Organizer: The 9th Federation of the Asian and Oceanian Physiological Societies Congress
  • Int'l Joint Research
• [Presentation] Cognitive Function and Hippocampus Volume in Chronic Obstructive Pulmonary Disease. (2018)
  • Author(s): R. Manabe, Y. Masaoka, K. Okuda, M. Yoshida, A. Yoshikawa, S. Kubota, H. Sato, H. Yamagami, K. Hirai, S. Ohta, T. Homma, T. Kawahara, H. Mikuni, N. Kuwahara, T. Kimura, M. Jinno, Y. Miyata, M. Yamaguchi, H. Inoue, F. Yamaguchi, M. Yamamoto, S. Kusumoto, S. Suzuki, A. Tanaka, T. Ohnishi, M. Ida, H. Sagara, M. Izumizaki.
  • Organizer: American Thoracic Society 2018 International Conference
  • Int'l Joint Research
• [Presentation] Cognitive function and morphological brain changes in chronic obstructive pulmonary disease. (2018)
  • Author(s): Manabe, R., Masaoka, Y., Okuda, K., Yoshida, M., Yoshikawa, A., Kubota, S., Satoh, H., Yamaue, H., Ida, M., Segara,H., Izumizaki, M.
  • Organizer: 第46回日本磁気共鳴医学会大会
• [Presentation] Default mode network and cognitive function: investigating into resting-state funcional connectivity between hemisphere. (2018)
  • Author(s): Yoshikawa, A., Ida, M., Masaoka, Y., Yoshida, M., Koiwa, N., Kubota, S., Manabe, R., Iizuka, N., Izumizaki, M.
  • Organizer: 第46回日本磁気共鳴医学会大会
• [Presentation] COPD患者における脳の構造性変化について (2018)
  • Author(s): 眞鍋亮, 政岡ゆり, 奥田健太郎, 吉田正樹, 吉川輝, 久保田怜美, 井田瞳, 井田正博, 相良博典, 泉崎雅彦
  • Organizer: 第28回日本呼吸ケア・リハビリテーション学会学術集会