The study on Immunosenescence in Chronic Obstructive Pulmonary Disease
| Project/Area Number |
18K08188
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 53030:Respiratory medicine-related
|
|---|
| Research Institution | Akita University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
荒屋 潤 東京慈恵会医科大学, 医学部, 教授 (90468679)
|
|---|
| Project Period (FY) |
2018-04-01 – 2023-03-31
|
| Project Status |
Completed (Fiscal Year 2022)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Keywords | COPD / 細胞老化 / 酸化ストレス / 肺胞マクロファージ / 体表肺エコー検査 / statin / HO-1 / i-ULCs / 線維化 / 間質性肺炎 / 肺機能 / PARK2 / LaminB1 / NCOA4 / 慢性閉塞性肺疾患 / 免疫老化 / 易感染性 / 易炎症性 |
|---|
| Outline of Final Research Achievements |
To validate cellular senescence and chronic inflammation in COPD, we examined the expression of senescence-related factors (PARK2, LaminB1, NCOA4) in peripheral blood and the expression of innate immune system agonist molecules (ADMATS20, SPHK2, TNFSF14) by CSE stimuli to alveolar MF, but no significant trends were obtained. On the other hand, a significant association between the number of i-ULCs by body surface lung ultrasonography and lung function decline was demonstrated for interstitial pneumonia, which is related to smoking and cellular senescence, and statin stimulation of HBECs induced the expression of the antioxidant stressor HO-1. From the latter, an investigation of anti-aging effects of statin on airway epithelium is planned. Due to the COVID-19 disaster in the study period, difficulties were encountered in specimen collection. We obtained basic data that are expected to be validated and developed.
|
| Academic Significance and Societal Importance of the Research Achievements |
COPDでの細胞内老化関連因子を末血ELISAで簡易に評価することは難しいことが示された。また、肺胞MFへの喫煙刺激による自然免疫系作動分子発現は一様ではなく基礎疾患により変動することが示された。免疫系も含めた細胞老化の評価の簡易化はまだ難しく、個々の症例で細胞種の違いも勘案して検討することが必要である。
|
Report
(6 results)
Research Products
(77 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Impaired TRIM16-Mediated Lysophagy in Chronic Obstructive Pulmonary Disease Pathogenesis2021
Author(s)
J Araya, N Saito, Y Hosaka, A Ichikawa, T Kadota, Y Fujita, S Minagawa, H Hara, S Fujimoto, H Kawamoto, N Watanabe, A Ito, K Okuda, H Miyagawa, J Watanabe, D Takekoshi、H Utsumi, M Yoshida, M Hashimoto, H Wakui, S Ito, T Numata, S Mori, H Matsudaira, J Hirano, T Ohtsuka, K Nakayama, K Kuwano
-
Journal Title
The Journal of Immunology
Volume: 207
Issue: 1
Pages: 65-76
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Efficacy of mepolizumab for patients with severe asthma and eosinophilic chronic rhinosinusitis.2019
Author(s)
Numata T, Nakayama K, Utsumi H, Kobayashi K, Yanagisawa H, Hashimoto M, Minagawa S, Ishikawa T, Hara H, Araya J, Kuwano K.
-
Journal Title
BMC Pulm Med.
Volume: 19
Issue: 1
Pages: 176-176
DOI
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Involvement of cigarette smoke-induced epithelial cell ferroptosis in COPD pathogenesis.2019
Author(s)
Yoshida M, Minagawa S, Araya J, Sakamoto T, Hara H, Tsubouchi K, Hosaka Y, Ichikawa A, Saito N, Kadota T, Sato N, Kurita Y, Kobayashi K, Ito S, Utsumi H, Wakui H, Numata T, Kaneko Y, Mori S, Asano H, Yamashita M, Odaka M, Morikawa T, Nakayama K, Iwamoto T, Imai H, Kuwano K.
-
Journal Title
Nat Commun.
Volume: 10
Issue: 1
Pages: 3145-3145
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Risk factors of postoperative pulmonary complications in patients with asthma and COPD.2018
Author(s)
Numata T, Nakayama K, Fujii S, Yumino Y, Saito N, Yoshida M, Kurita Y, Kobayashi K, Ito S, Utsumi H, Yanagisawa H, Hashimoto M, Wakui H, Minagawa S, Ishikawa T, Hara H, Araya J, Kaneko Y, Kuwano K.
-
Journal Title
BMC Pulm Med.
Volume: 18
Issue: 1
Pages: 1-8
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
[Presentation] Association between proton-pump inhibitors and the ABCG2 C421A polymorphism and plasma concentration of gefitinib2021
Author(s)
Sakamoto,S.,Sato,K.,Goshima,S.,Asahi,R.,Takita,Y.,Omoto,E.,Izumiya,Y., Kumagai,N.,Hasegawa,Y.,Yokota,H.,Okuda,Y.,Asano,M.,Akamine,Y.,Takeda,M.,Miura,M. and Nakayama,K.
Organizer
The 25th Congress of the Asian Pacific Society of Respirology, November, Hybrid (Kyoto)
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Role of chaperone-mediated autophagy in COPD pathogenesis.2018
Author(s)
Yusuke Hosaka, Jun Araya, Kazuya Tsubouchi, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Masahiro Yoshida, Takeo Ichikawa, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
Organizer
European Respiratory Society International Congress 2018
Related Report
Int'l Joint Research
-
[Presentation] Involvement of NCOA4-mediated ferritinophagy in cigarette smoke-induced ferroptosis in COPD pathogenesis2018
Author(s)
Masahiro Yoshida, Shunsuke Minagawa, Jun Araya, Hiromichi Hara, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Kazuya Tsubouchi, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano.
Organizer
European Respiratory Society International Congress 2018
Related Report
Int'l Joint Research
-
[Presentation] Involvement of GPx4-regulated lipid peroxidation in IPF pathogenesis.2018
Author(s)
Kazuya Tsubouchi, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Yusuke Hosaka, Akihiro Ichikawa, Nayuta Saito, Masahiro Yoshida, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Katsutoshi Nakayama, Kazuyoshi Kuwano
Organizer
European Respiratory Society International Congress 2018
Related Report
Int'l Joint Research
-
-
-
-
-
-
-
