Elucidation of mechanism and development of novel biomarkers on a perception of dyspnea with effort breathing based on multidimensional analyses

• Project/Area Number: 18K08195
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Kurume University
• Principal Investigator: KAWAYAMA TOMOTAKA 久留米大学, 医学部, 教授 (80289389)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 努力性呼吸 / 機能的MRI / 呼吸困難 / 脳内ネットワーク / 呼吸筋仕事量

Outline of Final Research Achievements

We performed resting functional MRI in 20 healthy young adults, with and without using the upper airflow loading devices. When breathing is difficult using the devices; the connectivity between the posterior-frontal orbitofrontal cortex, and 1) primary sensory area-anterior cingulate gyrus-secondary visual cortex-anterior insular cortex, 2) primary motor area-supplementary motor area, 3) middle temporal gyrus was increased. These results suggest 1) the activity of sensory and emotion-related areas, 2) the activity of motor-related areas, and 3) the activity of emotion control areas in difficulty in breathing.

Academic Significance and Societal Importance of the Research Achievements

他覚的に評価しにくい呼吸困難を機能的MRIで可視化することに成功した。このことは呼吸困難の発生機序の解明および治療に貢献すると思われる。