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Analysis of signal pathways from primary cilia that control cystic kidney disease

Research Project

Project/Area Number 18K08215
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53040:Nephrology-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Nakajima Yoshiro  京都府立医科大学, 医学(系)研究科(研究院), 助教 (30455430)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywordsネフロン癆 / 一次繊毛 / NPHP / ANKS6(NPHP16) / BICC1 / ANKS3 / ルートレット / BICC-ANKS3-ANKS6複合体 / ルートレティン / 翻訳抑制 / ANKS6 / RNA結合タンパク質 / 超解像顕微鏡 / シグナル伝達 / 細胞質顆粒
Outline of Final Research Achievements

The nephronophthisis protein (NPHP) is mainly localized to the primary cilia, which are intracellular organelles. Signals transmitted by primary cilia are thought to regulate cell proliferation, cell polarity, cell differentiation, and so on. In this study, we analyzed a molecular complex thought to be involved in signal transduction from cilia. As a result, it was revealed that ANKS6, which is NPHP16, is accumulated in the ciliary rootlet in addition to the primary cilia INV compartment. Furthermore, BICC1 and ANKS3, which are cystic kidney-related proteins, were also confirmed to be localized in the rootlet, suggesting that they form a large complex with ANKS6 and are involved in the maintenance of renal morphology.

Academic Significance and Societal Importance of the Research Achievements

嚢胞腎関連遺伝子であるANKS6, BICC1, ANKS3の局在、結合能などを詳細に解析した結果、BICC1-ANKS3-ANKS6は一次繊毛ルートレットに局在し、巨大な複合体を形成していることを明らかにした。その結果、これまで数多く報告されてきたが未解明な点が多かった嚢胞腎関連遺伝子間の相互作用の理解に貢献できたと考える。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (4 results)

All 2021 2020 Other

All Presentation (3 results) Remarks (1 results)

  • [Presentation] BICC1-ANKS3-ANKS6複合体の繊毛局在の同定2021

    • Author(s)
      中島由郎
    • Organizer
      第126回日本解剖学会総会・全国学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多発性嚢胞腎関連タンパク質BICC1の機能解析2020

    • Author(s)
      中島由郎、松尾和彦、八代健太
    • Organizer
      第125回日本解剖学会総会・全国学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 多発性嚢胞腎タンパク質BICC1の機能解析2020

    • Author(s)
      1.中島由郎, 松尾一彦, 八代健太
    • Organizer
      日本解剖学会総会
    • Related Report
      2019 Research-status Report
  • [Remarks] 京都府立医科大学 医学研究科 生体機能形態科学部門ホームページ

    • URL

      http://www.f.kpu-m.ac.jp/k/devheart/

    • Related Report
      2020 Annual Research Report

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Published: 2018-04-23   Modified: 2022-01-27  

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