| Project/Area Number |
18K08219
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Keio University |
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Principal Investigator |
HIRAYAMA Akiyoshi 慶應義塾大学, 政策・メディア研究科(藤沢), 特任講師 (00572405)
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| Co-Investigator(Kenkyū-buntansha) |
丸山 彰一 名古屋大学, 医学系研究科, 教授 (10362253)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2019: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ネフローゼ / メタボローム解析 / 尿 / バイオマーカー / メタボロミクス |
|---|
| Outline of Final Research Achievements |
In this study, a comprehensive analysis of urinary metabolites from nephrotic disease patients was conducted by capillary electrophoresis-mass spectrometry (CE-MS) in order to discover biomarkers specific to the type of disease.
As a result, it is possible to identify a novel biomarker for discriminating lupus nephritis and to create a model for discriminating a specific disease from 7 types of nephrotic diseases by combining 2 to 5 kinds of metabolites.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究で得られた新規バイオマーカーは、ループス腎炎の早期診断に使用できるのみならず、治療薬開発や治療効果の判定に役立つ可能性がある。尿は非侵襲に採取できるため、メタボローム解析と組み合わせることによって、より広範な疾患のスクリーニングに使える可能性を秘めている。
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