| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The glomerular capillaries responsible for glomerular filtration are surrounded by two cells. One is a podocyte, which forms a specialized filter called a slit diaphragm to filtrate blood. The other is a mesangial cell, which regulates the diameter of capillary and control blood flow. We found that glomerular capillaries have two large domain structures and express different molecules depending on the type of surrounding cells. The study demonstrates that it is possible to clarify the fact that endothelial cells constituting one capillary are not uniform and change their properties in various way according to the surrounding environment and are involved in tissue-specific functions.
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