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Regulation of urinary microRNA expression in renal diseases and its utility as a biomarker

Research Project

Project/Area Number 18K08229
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53040:Nephrology-related
Research InstitutionYamagata University

Principal Investigator

Konta Tsuneo  山形大学, 医学部, 教授 (60333952)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
KeywordsmicroRNA / 腎臓病
Outline of Final Research Achievements

In this study, we analyzed microRNAs in blood and urine of 150 healthy subjects and patients with renal diseases and found that (1) various microRNAs are expressed in glomerular, tubular, and interstitial cells, (2) microRNA expression in renal tissues correlates with microRNA expression in urine, (3) urinary microRNA expression profiles differ depending on the type of renal lesion, and (4) specific urinary microRNAs are associated with decreased renal function.
These results suggest that various microRNAs are involved in the onset and progression of renal diseases and that urinary microRNAs reflect the expression of renal tissue microRNAs and the pathogenesis of renal disorders. Therefore, urinary microRNAs can be a prognostic biomarker for renal diseases.

Academic Significance and Societal Importance of the Research Achievements

本研究では、尿microRNAは腎臓病の予後を予測する指標となりうることが示唆された。腎臓病は心臓病や脳卒中との関連が強いことから、microRNAと各疾患との関連についての検討をさらに進めることで、microRNAを対象とした幅広い疾患の新しい治療法の開発につながる可能性がある。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (3 results)

All 2020 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Association among chronic kidney disease, airflow limitation, and mortality in a community-based population: The Yamagata (Takahata) study.2020

    • Author(s)
      Suzuki N, Matsuki E, Araumi A, Ashitomi S, Watanabe S, Kudo K, Ichikawa K, Inoue S, Watanabe M, Ueno Y, Ishizawa K, Kayama T, Konta T.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 5570-5570

    • DOI

      10.1038/s41598-020-62540-8

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The association between urinary sodium excretion and blood pressure in a community-based population: the Yamagata (Takahata) study2018

    • Author(s)
      Watanabe Sayumi、Konta Tsuneo、Ichikawa Kazunobu、Watanabe Masafumi、Ishizawa Kenichi、Ueno Yoshiyuki、Yamashita Hidetoshi、Kayama Takamasa、Kubota Isao
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 23 Issue: 3 Pages: 380-386

    • DOI

      10.1007/s10157-018-1654-3

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] The correlation between urinary microRNA-21 and renal parameters in patients with IgA nephropathy2020

    • Author(s)
      Akira Araumi, Tsukasa Osaki, Kazunobu Ichikawa, Masafumi Watanabe, Tsuneo Konta
    • Organizer
      Kidney Week 2020, Denver USA, Oct 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research

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Published: 2018-04-23   Modified: 2022-01-27  

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