| Project/Area Number |
18K08235
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Niigata University |
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Principal Investigator |
Sato Hiroe 新潟大学, 保健管理・環境安全本部, 講師 (80705963)
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| Co-Investigator(Kenkyū-buntansha) |
金子 佳賢 新潟大学, 医歯学系, 講師 (80444157)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | ループス腎炎 / 抗リボソームP抗体 |
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| Outline of Final Research Achievements |
In vivo administration of anti-P antibody induced infiltration of monocytes/macrophages in glomeruli and deterioration of kidney function. On the other hand, a lupus patient with anti-P without anti-DNA antibody showed class Ⅴ histology and maintained good renal function, which were different results from in vivo experiments. The reason of this discrepancy might be that the binding affinity to antigen was different between human anti-P and monoclonal anti-P. Five patients with both anti-P and anti-DNA antibodies showed proliferative nephritis and were frequently associated with prolonged hypocomplementemia. Thus, anti-P itself could independently affect lupus nephritis, and further research is required.
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| Academic Significance and Societal Importance of the Research Achievements |
これまで抗P抗体のループス腎炎における意義については報告により異なっていた。本研究では初めて抗Pモノクローナル抗体をマウスに投与することで抗P抗体単独での作用について解析することが可能であり、抗P抗体自体が糸球体障害を起こす可能性が示唆された。またループス腎炎症例の解析では抗DNA抗体の併存の有無により重症度に差があることが示され、治療方針の決定にも有用な知見が得られた。
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