| Project/Area Number |
18K08252
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | IgA腎症 / 粘膜免疫 / 免疫複合体 / ホーミング / Toll様受容体 / APRIL / TLR / 糖鎖異常IgA1 |
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| Outline of Final Research Achievements |
Dysregulation of mucosal immune response is involved in the pathogenesis of IgA nephropathy. However, the whereabouts of the responsible cells involved in the production of glycan abnormality IgA1 have not been identified. In present study, it was clarified that aberrantly glycosylated IgA-producing cells, which are key molecular in the pathophysiology of IgA nephropathy, are mainly desensitized and differentiated in nasopharynx-associated lymphoid tissue (NALT) using a natural onset model of IgA nephropathy. Analysis of homing receptors suggested that aberrantly glycosylated IgA-producing cells sensitized in NALT are homing into the bone marrow and differentiate to long-lived plasma cells.
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| Academic Significance and Societal Importance of the Research Achievements |
IgA腎症は世界で最も頻度の高い原発性糸球体腎炎であり、腎糸球体に糖鎖修飾異常を伴ったIgA（糖鎖異常IgA）の沈着を特徴とする。予後不良な疾患であり、指定難病に認定されている。現在、科学的根拠がないまま扁桃摘出あるいは腸管選択的作用型ステロイドを用いた治験などが進行している。本研究成果により、科学的根拠をもった適切な治療ガイドを示すことが可能である。IgA腎症の予後を改善することで透析導入を抑制し、医療費の削減を図ることが可能であると考える。
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