| Project/Area Number |
18K08253
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53040:Nephrology-related
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| Research Institution | Showa University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
緒方 浩顕 昭和大学, 医学部, 教授 (30296959)
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 血管石灰化 / カルシトリオール / VDR / 内皮細胞 / ビタミンD / 炎症 / CKD-MBD |
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| Outline of Final Research Achievements |
Rat aortic rings and HUVECs were incubated in the normal or the high Ca/high P media. Aortic Ca content, and mRNA levels of endothelial cell markers (CD31, VE-cadherin, and ZO-1) and permeability were studied, respectively. Also, the effect of calcitriol on vascular calcification was studied by using vascular smooth muscle cell-specific VDR conditional knockout mice. Calcitriol inhibited exacerbation of vascular calcification by the suppression of HUVEC hyperpermeability. Moreover, calcitriol-VDR axis could not be involved in the progression of vascular calcification induced by high doses of calcitriol.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、活性型ビタミンDのカルシトリオールは、CaやPのミネラル負荷による血管内皮細胞障害の抑制作用を有し、また、VDRを介した血管石灰化促進作用はみられなかったことから、ミネラル代謝異常を引き起こさないように適切に使用することにより、血管保護作用が期待されることから、動脈硬化対策の選択肢のひとつとなり得る。
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