| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Several drugs with frequently reported drug eruptions were expected to cause severe drug eruptions in individuals with HLA-B*13:01 due to their common structure with aromatics and a double bonded oxygen near the aromatics.
We found that baicalin inhibits cell death by blocking the binding of Annexin A1 and FRP1, which are involved in cell death in severe drug eruption SJS/TEN, and inhibiting the activation of RIP1 and RIP3, and thus may be a candidate for the treatment of SJS.
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