Elucidation of pathomechanisms of deficiency of interleukin-36 receptor antagonist to develop innovative therapies for the disease

• Project/Area Number: 18K08281
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Fujita Health University
• Principal Investigator: SUGIURA Kazumitsu 藤田医科大学, 医学部, 教授 (70335032)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Project Status: Completed (Fiscal Year 2020)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: IL-36受容体拮抗因子欠損症 / IL36RN / 膿疱性乾癬 / 好中球細胞外トラップ / ノックアウトマウス / 接触皮膚炎 / 創傷治癒 / TLR4 / 尋常性乾癬 / 皮膚潰瘍 / IL-36受容体拮抗因子 / TLR-4 / 膿疱性乾癬モデルマウス

Outline of Final Research Achievements

The principal investigators found that the majority of the etiology of the designated intractable pustular psoriasis (generalized) (GPP) was IL-36 receptor antagonist (IL-36Ra) deficiency (DITRA). We investigate the pathophysiology of various skin disorders in DITRA. The purpose of this studies are follows; (1) to analyzed therapeutic effect of DITRA of neutrophil extracellular traps (NETs) inhibitors on GPP model (2) to elulcidate pathophysiology of exacerbation of contact dermatitis due to IL-36Ra deficiency (3) to elucidate pathphysiology of prolong the healing of skin ulcers due to IL-36Ra deficiency. As a result of the research, NETs have been shown to be new therapeutic targets in DITRA. It was revealed that IL-36Ra deficiency can be an exacerbating factor for contact dermatitis and wound healing. Furthermore, it was suggested that inhibition of TLR4 signal by TAK-242 may be a new therapeutic agent for contact dermatitis and wound healing.

Academic Significance and Societal Importance of the Research Achievements

IL-36Ra欠損症のGPP様の皮疹ではNETｓが亢進していることを証明し、GPPの新たな知見を提供した。さらに、NETsはDITRAにおいて新たな治療標的となることを提示した。さらに、IL-36Ra欠損が、好中球炎症を引き起こし、接触性皮膚炎と創傷治癒を増悪させることを示した。TAK-242によるTLR4シグナルの阻害が接触皮膚炎と創傷治癒の新たな治療薬となる可能性を示唆した。

Research Products

• [Journal Article] Efficacy and safety of treatments with anti-TNF-α drugs for severe impetigo herpetiformis. (2021)
  • Author(s): Fukushima H, Iwata Y, Arima M, Tanaka Y, Sugiura K.
  • Journal Title: J Dermatol Volume: 48 Issue: 2 Pages: 207-210
  • DOI: 10.1111/1346-8138.15635
  • Peer Reviewed
• [Journal Article] Erythro-papular type drug eruption caused by fosravuconazole L-lysine ethanolate. (2021)
  • Author(s): Kumano Y, Nagai A, Sugiura K.
  • Journal Title: Eur J Dermatol Volume: 31 Issue: 1 Pages: 90-91
  • DOI: 10.1684/ejd.2020.3950
  • Peer Reviewed
• [Journal Article] SASP-induced macrophage dysfunction may contribute to accelerated senescent fibroblast accumulation in the dermis. (2021)
  • Author(s): Ogata Y, Yamada T, Hasegawa S, Sanada A, Iwata Y, Arima M, Nakata S, Sugiura K, Akamatsu H.
  • Journal Title: Exp Dermatol Volume: 30 Issue: 1 Pages: 84-91
  • DOI: 10.1111/exd.14205
  • Peer Reviewed
• [Journal Article] Gremlin 2 increased in the skin with age as a SASP factor. (2020)
  • Author(s): Kawagishi-Hotta M, Hasegawa S, Hasebe Y, Sugiura K, Akamatsu H.
  • Journal Title: J Dermatol Volume: 47 Issue: 12 Pages: 1457-1458
  • DOI: 10.1111/1346-8138.15578
  • Peer Reviewed
• [Journal Article] Neutrophil extracellular traps are induced in a psoriasis model of interleukin-36 receptor antagonist-deficient mice. (2020)
  • Author(s): Watanabe S, Iwata Y, Fukushima H, Saito K, Tanaka Y, Hasegawa Y, Akiyama M, Sugiura K.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 20149-20149
  • DOI: 10.1038/s41598-020-76864-y
  • Peer Reviewed / Open Access
• [Journal Article] Successful treatment with intravenous immunoglobulin and rituximab for bronchiolitis obliterans associated with paraneoplastic pemphigus (2020)
  • Author(s): Kaibuchi-Ando K, Sugiura K, Muro Y, Takahashi Y, Kojima S, Ishii N, Hashimoto T, Akiyama M
  • Journal Title: J Dermatol Volume: 47 Issue: 10
  • DOI: 10.1111/1346-8138.15496
  • Peer Reviewed
• [Journal Article] IL-36 receptor antagonist deficiency resulted in delayed wound healing due to excessive recruitment of immune cells. (2020)
  • Author(s): Saito K, Iwata Y, Fukushima H, Watanabe S, Akiyama M, Sugiura K.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 14772-14772
  • DOI: 10.1038/s41598-020-71256-8
  • Peer Reviewed / Open Access
• [Journal Article] Mild epidermolytic ichthyosis with palmoplantar keratoderma due to the KRT1 mutation p.lle479Thr. (2020)
  • Author(s): Murase Y, Tanahashi K, Takeichi T, Sugiura K, Aiyama A, Nishida K, Mitsuma T, Akiyama M.
  • Journal Title: J Dermatol Volume: 47 Issue: 9
  • DOI: 10.1111/1346-8138.15476
  • Peer Reviewed
• [Journal Article] An unexpected side effect of dupilumab: reversal of hair graying. (2020)
  • Author(s): Sumitomo C, Akita H, Sugiura K.
  • Journal Title: J Dermatol Volume: 47 Issue: 9
  • DOI: 10.1111/1346-8138.15472
  • Peer Reviewed
• [Journal Article] Autoinflammatory Keratinization Diseases (AiKDs). (2020)
  • Author(s): Akiyama M, de Vita V, Sugiura K.
  • Journal Title: Front Immunol Volume: 11 Pages: 1753-1753
  • DOI: 10.3389/fimmu.2020.01753
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correlation between immune-related adverse events and prognosis in patients with various cancers treated with anti PD-1 antibody. (2020)
  • Author(s): Matsuoka H, Hayashi T, Takigami K, Imaizumi K, Shiroki R, Ohmiya N, Sugiura K, Kawada K, Sawaki A, Maeda K, Ando Y, Uyama I.
  • Journal Title: BMC Cancer Volume: 20 Issue: 1 Pages: 656-656
  • DOI: 10.1186/s12885-020-07142-3
  • Peer Reviewed / Open Access
• [Journal Article] Zinc‐responsive necrolytic acral erythema in ovarian cancer (2020)
  • Author(s): Fukushima Hidehiko、Fujii Takuma、Sugiura Kazumitsu
  • Journal Title: The Journal of Dermatology Volume: 47 Issue: 7
  • DOI: 10.1111/1346-8138.15363
  • Peer Reviewed
• [Journal Article] Refractory skin ulcers associated with Klinefelter syndorome. (2020)
  • Author(s): Saito K, Iwata Y, Kobayashi T, Sugiura K.
  • Journal Title: J Dermatol Volume: 47 Issue: 5
  • DOI: 10.1111/1346-8138.15287
  • Peer Reviewed
• [Journal Article] Generalized pustular psoriasis-like drug eruption manifested by systemic glucocorticosteroid in a patient without IL36RN mutation and immunologic disorders. (2020)
  • Author(s): Sakai T, Matsuda-Hirose H, Shimada H, Sugiura K, Hatano Y.
  • Journal Title: Eur J Dermatol Volume: 30 Issue: 2 Pages: 183-184
  • DOI: 10.1684/ejd.2020.3719
  • Peer Reviewed
• [Journal Article] TAK-242 ameliorates contact dermatitis exacerbated by IL-36 receptor antagonist deficiency. (2020)
  • Author(s): Fukushima H, Iwata Y, Watanabe S, Saito K, Tanaka Y, Hasegawa Y, Akiyama M, Sugiura K.
  • Journal Title: Sci Rep Volume: 10 Issue: 1 Pages: 734-734
  • DOI: 10.1038/s41598-020-57550-5
  • Peer Reviewed / Open Access
• [Journal Article] Acute generalized exanthematous pustulosis induced by hydroxychloroquine successfully treated with etretinate. (2020)
  • Author(s): Matsuda-Hirose H, Sho Y, Yamate T, Nakamura Y, Saito K, Takeo N, Nishida H, Ishii K, Sugiura K, Hatano Y.
  • Journal Title: J Dermatol Volume: 47 Issue: 2
  • DOI: 10.1111/1346-8138.15185
  • Peer Reviewed
• [Journal Article] Real-world single-center experience with ten cases of generalized pustular psoriasis successfully treated with ixekizumab. (2020)
  • Author(s): Nagata M, Kamata M, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Sugiura K, Tada Y.
  • Journal Title: J Am Acad Dermatol Volume: 82 Issue: 3 Pages: 758-761
  • DOI: 10.1016/j.jaad.2019.09.040
  • Peer Reviewed
• [Journal Article] Increase of Gremlin 2 with age in human adipose-derived stromal/stem cells and its inhibitory effect on adipogenesis. (2019)
  • Author(s): Kawagishi-Hotta M, Hasegawa S, Igarashi T, Date Y, Ishii Y, Inoue Y, Hasebe Y, Yamada T, Arima M, Iwata Y, Kobayashi T, Nakata S, Sugiura K, Akamatsu H.
  • Journal Title: Regen Ther Volume: 11 Pages: 324-330
  • DOI: 10.1016/j.reth.2019.09.002
  • Peer Reviewed
• [Journal Article] LAT1‐specific inhibitor is effective against T cell‐mediated allergic skin inflammation (2019)
  • Author(s): Hayashi Keitaro、Kaminuma Osamu、Nishimura Tomoe、Saeki Mayumi、Matsuoka Kunie、Hiroi Takachika、Jutabha Promsuk、Iwata Yohei、Sugiura Kazumitsu、Owada Takayoshi、Kurasawa Kazuhiro、Okayasu Isao、Ouchi Motoshi、Fujita Tomoe、Kanai Yoshikatsu、Endou Hitoshi、Anzai Naohiko
  • Journal Title: Allergy Volume: 75 Issue: 2 Pages: 463-467
  • DOI: 10.1111/all.14019
  • NAID: 40022246112
  • Peer Reviewed
• [Journal Article] Oculodentodigital dysplasia diagnosed from severe hypotrichosis. (2019)
  • Author(s): Taki T, Takeichi T, Sugiura K, Akiyama M.
  • Journal Title: Acta Dermato-Venereol Volume: 99 Issue: 13 Pages: 1307-1308
  • DOI: 10.2340/00015555-3277
  • Peer Reviewed / Open Access
• [Journal Article] A patient with bullous pemphigoid with mucosal involvement serologically positive for anti‐BP230 autoantibodies only (2019)
  • Author(s): Taki T.、Takeichi T.、Kono M.、Sugiura K.、Sugimura Y.、Ishii N.、Hashimoto T.、Akiyama M.
  • Journal Title: British Journal of Dermatology Volume: 182 Pages: 221-223
  • DOI: 10.1111/bjd.18343
  • Peer Reviewed
• [Journal Article] A case of generalized pustular psoriasis with coexisting mutations in IL36RN and CARD14. (2019)
  • Author(s): Sawabe Y, Hayashi K, Kamata M, Nagata M, Fukaya S, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Tanaka M, Sugiura K, Tada Y.
  • Journal Title: J Dermatol Volume: 46 Issue: 10
  • DOI: 10.1111/1346-8138.14909
  • Peer Reviewed
• [Journal Article] Efficacy of long-term treatment with efinaconazole 10% solution in patients with onychomycosis; including severe cases: a multicenter, single-arm study. (2019)
  • Author(s): Iozumi K,.., Sugiura K, et al.
  • Journal Title: J Dermatol Volume: 46 Issue: 8 Pages: 641-651
  • DOI: 10.1111/1346-8138.14935
  • Peer Reviewed
• [Journal Article] UV irradiation-induced DNA hypomethylation around WNT1 gene: implications for solar lentigines. (2019)
  • Author(s): Yamada T, Hasegawa S, Iwata Y, Arima M, Kobayashi T, Numata S, Nakata S, Sugiura K, Akamatsu H.
  • Journal Title: Exp Dermatol Volume: 28 Issue: 6 Pages: 723-729
  • DOI: 10.1111/exd.13949
  • Peer Reviewed
• [Journal Article] Pediatric-onset annular pustular psoriasis in a patient with Down syndrome. (2019)
  • Author(s): Morita A, Kawakami Y, Kaji T, Hirai Y, Miyake T, Takahashi M, Yamasaki O, Sugiura K, Morizane S.
  • Journal Title: J Dermatol Volume: 46 Issue: 10
  • DOI: 10.1111/1346-8138.14896
  • Peer Reviewed
• [Journal Article] The lipoxygenase-hepoxilin pathway is activated in cutaneous plaque lesions of psoriasis. (2019)
  • Author(s): Takeichi T, Kinoshita F, Tanaka H, Fujita S, Kobayashi Y, Nakatochi M, Sugiura K, Akiyama M.
  • Journal Title: J Cutan Immunol Allergy Volume: -
  • Peer Reviewed
• [Journal Article] Generalized Pustular Psoriasis from heterozygous IL36RN mutation developed after liver surgery. (2019)
  • Author(s): Fukushima H, Iwata Y, Numata, Saito K, Watanabe S, Kobayashi T, Sugiura K.
  • Journal Title: J Deramtol Volume: - Issue: 8
  • DOI: 10.1111/1346-8138.14828
  • Peer Reviewed / Open Access
• [Journal Article] An effective and promising treatment with adalimumab for impetigo herpetiformis with postpartum flare-up. (2019)
  • Author(s): Yamashita T, Hamada T, Maruta Y, Kajita A, Hirai Y, Morizane S, Watanabe S, Sugiura K, Iwatsuki K.
  • Journal Title: Int J Dermatol Volume: 58 Issue: 3 Pages: 350-353
  • DOI: 10.1111/ijd.14141
  • Peer Reviewed
• [Journal Article] CXCL12 regulates differentiation of human immature melanocyte precursors as well as their migration. (2019)
  • Author(s): Yamada T, Hasegawa S, Hasebe Y, Kawagishi-Hotta M, Arima M, Iwata Y, Kobayashi T, Numata S, Yamamoto N, Nakata S, Sugiura K, Akamatsu H.
  • Journal Title: Arch Dermatol Res Volume: 311 Issue: 1 Pages: 55-62
  • DOI: 10.1007/s00403-018-1880-2
  • Peer Reviewed
• [Journal Article] Gastrointestinal bleeding with severe mucosal involvement in a patient with generalized pustular psoriasis without IL36RN mutation. (2019)
  • Author(s): Komatsuda S, Kamata M, Chijiwa C, Namiki K, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Abe K, Yamamoto T, Aozasa N, Sugiura K, Tada Y.
  • Journal Title: J Dermatol. Volume: 46 Issue: 1 Pages: 73-75
  • DOI: 10.1111/1346-8138.14711
  • Peer Reviewed
• [Journal Article] Extracellular proteoglycan decorin maintains human hair follicle stem cells. (2018)
  • Author(s): Miyachi K., Yamada T., Kawagishi-Hotta M., Hasebe Y., Date Y., Hasegawa S., Arima M., Iwata Y., Kobayashi T., Numata S., Yamamoto N., Nakata S., Sugiura K, Akamatsu H.
  • Journal Title: J Dermatol. Volume: 45 Issue: 12 Pages: 1403-1410
  • DOI: 10.1111/1346-8138.14678
  • Peer Reviewed
• [Journal Article] Autosomal dominant progressive hyperpigmentation and lentigines in a Japanese pedigree due to a missense mutation near the C-terminus of KIT. (2018)
  • Author(s): Takeichi T, Sugiura K, Tanahashi K, Noda K, Kono M, Akiyama M.
  • Journal Title: Br J Dermatol Volume: 179 Issue: 5 Pages: 1210-1211
  • DOI: 10.1111/bjd.16895
  • Peer Reviewed
• [Journal Article] Hearing impairment; a secondary symptom in a congenital ichthyosiform erythroderma patient with ABCA12 mutations. (2018)
  • Author(s): Murase C, Takeichi T, Sugiura K, Kobayashi M, Shiomi K, Ikebuchi K, Akiyama M.
  • Journal Title: J Dermatol Volume: 45 Issue: 11
  • DOI: 10.1111/1346-8138.14350
  • Peer Reviewed
• [Journal Article] Deficiency of the interleukin-36 receptor antagonist dramatically improved by secukinumab. (2018)
  • Author(s): Kinoshita M, Okamoto T, Sano S, Mitsui H, Takeichi T, Sugiura K, Akiyama M, Shimada S, Kawamura T.
  • Journal Title: J Dermatol Volume: 45 Issue: 10
  • DOI: 10.1111/1346-8138.14330
  • Peer Reviewed
• [Journal Article] Herpes vegetans accompanied by Good’s syndrome. (2018)
  • Author(s): Hagiwara H, Iwata Y, Saito K, Watanabe S, Arima M, Ono Y, Mizoguchi Y, Kuroda M, Imaizumi K, Sugiura K.
  • Journal Title: J Dermatol Volume: 45 Issue: 10
  • DOI: 10.1111/1346-8138.14323
  • Peer Reviewed
• [Journal Article] Roles of aberrant hemichannel activities due to mutant connexin26 in the pathogenesis of KID syndrome. (2018)
  • Author(s): Taki T, Takeichi T, Sugiura K, Akiyama M.
  • Journal Title: Sci Rep Volume: 8 Issue: 1 Pages: 12824-12824
  • DOI: 10.1038/s41598-018-30757-3
  • Peer Reviewed / Open Access
• [Journal Article] Recurrent Cutaneous Rosai-Dorfman Disease: A case Report. (2018)
  • Author(s): Yoshimoto N, Iwata Y, Numata S, Saito K, Iwata T, Arima M, Shima H, Tahara S, Kuroda M, Sugiura K.
  • Journal Title: Eur J Dermatol Volume: 28 Issue: 4 Pages: 562-563
  • DOI: 10.1684/ejd.2018.3348
  • Peer Reviewed
• [Journal Article] Filaggrin gene mutations may influence the persistence of food allergies in Japanese primary school children (2018)
  • Author(s): Kono M.、Akiyama M.、Inoue Y.、Nomura T.、Hata A.、Okamoto Y.、Takeichi T.、Muro Y.、McLean W.H.I.、Shimizu H.、Sugiura K.、Suzuki Y.、Shimojo N.
  • Journal Title: British Journal of Dermatology Volume: - Issue: 1 Pages: 190-191
  • DOI: 10.1111/bjd.16375
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Metastatic Crohn’s disease in childhood: A case report. (2018)
  • Author(s): Saito K, Iwata Y, Nakajima Y, Numata S, Sugiura K.
  • Journal Title: J Dermatol Volume: 45 Issue: 7
  • DOI: 10.1111/1346-8138.14215
  • Peer Reviewed
• [Journal Article] Case of lichenoid-lichen scrofulosorum: A rare variety of lichen scrofulosorum mimicking lichen planus in an elderly patient. (2018)
  • Author(s): Kondo M, Iwata Y, Numata S, Saito K, Watanabe S, Kobayashi T, Nagai A, Iwata T, Arima M, Sugiura K.
  • Journal Title: J Dermatol Volume: 45 Issue: 6
  • DOI: 10.1111/1346-8138.14184
  • Peer Reviewed
• [Journal Article] Autoinflammatory keratinization diseases: an emerging concept encompassing various inflammatory keratinization disorders of the skin. (2018)
  • Author(s): Akiyama M, Takeichi T, McGrath JA, Sugiura K.
  • Journal Title: J Dermatol Sci Volume: 90 Issue: 2 Pages: 105-111
  • DOI: 10.1016/j.jdermsci.2018.01.012
  • NAID: 120006517661
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nasal dermoid sinus cyst in a young girl: A case report. (2018)
  • Author(s): Iwata Y, Kodera M, Okumoto T, Numata S, Watanabe S, Saito K, Inasaka Y, Ito Y, Tanaka Y, Sugiura K.
  • Journal Title: J Dermatol Volume: 45 Issue: 5
  • DOI: 10.1111/1346-8138.14141
  • Peer Reviewed
• [Journal Article] Laminin-332 regulates differentiation of human interfollicular epidermal stem cells. (2018)
  • Author(s): Yamada T., Hasegawa S., Miyachi K., Date Y., Inoue Y., Yagami A., Arima M., Iwata Y., Yamamoto N., Nakata S., Matsunaga K., Sugiura K., Akamatsu H.
  • Journal Title: Mech Ageing Dev. Volume: 171 Pages: 37-46
  • DOI: 10.1016/j.mad.2018.03.007
  • Peer Reviewed
• [Presentation] 掌蹠膿疱症における 私のbio製剤の使い方 (2021)
  • Author(s): 杉浦一充
  • Organizer: 日本皮膚科学会青森地方会第393回例会
  • Invited
• [Presentation] 膿疱性乾癬と掌蹠膿疱症におけるトレムフィアの役割 (2021)
  • Author(s): 杉浦一充
  • Organizer: 日本皮膚科学会第396回福岡地方会
  • Invited
• [Presentation] 膿疱性乾癬と掌蹠膿疱症における トレムフィアの役割 (2020)
  • Author(s): 杉浦一充
  • Organizer: 第107回日本皮膚科学会大分地方会
  • Invited
• [Presentation] 乾癬における 好中球細胞外トラップの役割 (2020)
  • Author(s): 杉浦一充
  • Organizer: 第71回日本皮膚科学会中部支部学術大会
  • Invited
• [Presentation] Pathophysiology of generalized pustular psoriasis and possibility of personalized medicine for the future (2020)
  • Author(s): Kazumitsu Sugiura
  • Organizer: JSPR-IPC Joint Symposium
  • Int'l Joint Research / Invited
• [Presentation] 膿疱性乾癬と掌蹠膿疱症 ～類似点と相違点 (2020)
  • Author(s): 杉浦一充
  • Organizer: 第119回日本皮膚科学会総会・学術大会
  • Invited
• [Presentation] 膠原病の皮膚病変 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第6回総合アレルギー講習会
  • Invited
• [Presentation] 専門医試験にでる遺伝性角化症 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第83回日本皮膚科学会東京・東部支部 合同学術大会
  • Invited
• [Presentation] The role of interleukin-36 in psoriasis. (2019)
  • Author(s): Kazumitsu Sugiura
  • Organizer: 日本研究皮膚科学会年次学術大会・総会44回
  • Invited
• [Presentation] Autoinflammatory keratinization diseases. (2019)
  • Author(s): Kazumitsu Sugiura
  • Organizer: International Psoriasis Symposium
  • Invited
• [Presentation] 膿疱性乾癬と掌蹠膿疱症におけるトレムフィアの役割 (2019)
  • Author(s): 杉浦一充
  • Organizer: 日本皮膚科学会第227回熊本地方会
  • Invited
• [Presentation] 自己炎症性角化症 (2019)
  • Author(s): 杉浦 一充
  • Organizer: 2019年度日本皮膚科学会研修講習会ー必須（夏）－
  • Invited
• [Presentation] 自己炎症性角化症 (2019)
  • Author(s): 杉浦 一充
  • Organizer: 第118回日本皮膚科学会総会
  • Invited
• [Presentation] 乾癬における自然免疫と獲得免疫 ～当院における乾癬治療含め～ (2019)
  • Author(s): 杉浦一充
  • Organizer: 秋田県皮膚科談話会
  • Invited
• [Presentation] 自己炎症性角化症と掌蹠膿疱症における IL-23/IL-17の役割 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第189回鹿児島県皮膚科医部会例会 第24回日臨皮鹿児島県支部会
  • Invited
• [Presentation] 自己炎症性角化症としての乾癬 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第393回日本皮膚科学会新潟地方会
  • Invited
• [Presentation] 意外な遺伝性皮膚 (2019)
  • Author(s): 杉浦一充
  • Organizer: 第393回日本皮膚科学会新潟地方会疾患
  • Invited
• [Presentation] The Genetics of Pustular Psoriasis (2018)
  • Author(s): Kazumitsu Sugiura
  • Organizer: International Investigative Dermatology 2018
  • Int'l Joint Research / Invited
• [Presentation] 自己炎症性疾患としての乾癬 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第14回中国研究皮膚科セミナー
  • Invited
• [Presentation] 膿疱性乾癬の病態と治療 (2018)
  • Author(s): 杉浦一充
  • Organizer: 多摩皮膚科医会,
  • Invited
• [Presentation] 新たな疾患群、自己炎症性角化症 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第33回角化症研究会
  • Invited
• [Presentation] バイオマーカーとしての皮膚内在性幹細胞 (2018)
  • Author(s): 岩田洋平, 赤松浩彦, 長谷部祐一, 長谷川靖司, 杉浦一充
  • Organizer: 第48回日本創傷治癒学会
  • Invited
• [Presentation] 膿疱性乾癬と急性汎発性発疹性膿疱症の接点 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第48回日本皮膚免疫アレルギー学会総会学術大会
  • Invited
• [Presentation] 自己炎症性角化症としての乾癬 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第337回日本皮膚科学会長崎地方会
  • Invited
• [Presentation] 膿疱性乾癬の最新の病態と治療について (2018)
  • Author(s): 杉浦一充
  • Organizer: 第117回日本皮膚科学会総会
  • Invited
• [Presentation] 乾癬の現状 (2018)
  • Author(s): 杉浦一充
  • Organizer: 第29回緑病診連携研究会
  • Invited
• [Book] 乾癬・掌蹠膿疱症 (2020)
  • Author(s): 山本俊幸
  • Total Pages: 400
  • Publisher: 中山書店
• [Book] 皮膚疾患最新の治療 (2019)
  • Author(s): 古川福実・佐伯秀久
  • Publisher: 南江堂
• [Book] 皮膚症状110症例でみる内科疾患 (2018)
  • Author(s): 出光俊郎
  • Publisher: 日本医事新報社