Overexpression of D-dopachrome tautomerase increases ultraviolet B irradiation-induced skin tumorigenesis in mice
Project/Area Number |
18K08293
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53050:Dermatology-related
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Research Institution | University of Toyama |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
牧野 輝彦 富山大学, 学術研究部医学系, 准教授 (90359711)
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Project Period (FY) |
2018-04-01 – 2021-03-31
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Project Status |
Completed (Fiscal Year 2020)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | D-dopachrome tautomerase / MIF / ultraviolet / p53 / skin cancer / carcinogenesis / apoptosis / DDT / 紫外線 / 温熱 / 光発癌 / D-DT / HSP / 皮膚癌 |
Outline of Final Research Achievements |
Ultraviolet irradiation (UV) exposure is the leading factor underlying the development of skin malignancies. D-dopachrome tautomerase (D-DT), a functional homolog of macrophage migration inhibitory factor (MIF), has functional similarities to MIF. We explored the role of D-DT in photocarcinogenesis by developing D-DT transgenic (D-DT Tg) mice and provided a research model for future studies targeting D-DT. Chronic UVB exposure accelerated tumor development in D-DT Tg mice compared with wild-type (WT) mice, with a higher incidence of tumors observed in D-DT Tg mice than in WT mice. In D-DT Tg irradiated mouse keratinocytes, the p53, PUMA, and Bax expression was lower than that in WT mice. These results indicate that D-DT Tg overexpression confers prevention against UVB-induced apoptosis in keratinocytes. Taken together, these findings support D-DT as a functionally important cytokine in photocarcinogenesis and potential therapeutic target for the prevention of photocarcinogenesis.
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Academic Significance and Societal Importance of the Research Achievements |
D-DTは光発癌における機能的に重要なサイトカインであり,光発癌予防のための治療標的になりうることが証明された.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Autoantibodies detected in patients with vitiligo vulgaris but not in those with rhododendrol-induced leukoderma2019
Author(s)
Arase N, Tanemura A, Jin H, Nishioka M, Aoyama Y, Oiso N, Matsunaga K, Suzuki T, Nishigori C, Kawamura T, Shimizu T, Ito A, Fukai K, Abe Y, Yang L, Tsuruta D, Takeoka K, Iwatani Y, Hidaka Y, Nishida M, Yamauchi-Takihara K, Arase H, Fujimoto M, Katayama I.
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Journal Title
J Dermatol Sci.
Volume: 95(2)
Pages: 80-83
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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