A new barrier-related gene encoding epithelial stress-induced peptide
Project/Area Number |
18K08295
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53050:Dermatology-related
|
Research Institution | Kagawa University (2020) Kyoto University (2018) |
Principal Investigator |
|
Project Period (FY) |
2018-04-01 – 2021-03-31
|
Project Status |
Completed (Fiscal Year 2020)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 表皮 / 炎症 / バリア / アトピー性皮膚炎 / 乾癬 |
Outline of Final Research Achievements |
The epidermis is involved in barrier, innate and adaptive immunity of the skin. We found that up-regulation of an orphan gene was shared in the skin with different, many types of inflammation. We named this molecule epithelial stress-induced peptide (ESIP). The human orthologue gene product was highly expressed in the epidermis of atopic dermatitis or psoriasis. ESIP gene transfection into normal human epidermal keratinocytes induced expression of inflammatory mediators, and gene ontology analyses showed its association to barrier formation.
|
Academic Significance and Societal Importance of the Research Achievements |
ESIPが上皮ストレス応答のマスターレギュレーターであり、多様な臨床像を示すアトピー性皮膚炎の慢性炎症を決定づける表皮由来因子である可能性を考えた。これまでアトピー性皮膚炎などの慢性の炎症性皮膚疾患の治療標的は免疫細胞が主体であった。本研究成果により、全身の皮膚を覆う組織である表皮が、これらの皮膚疾患の新しい治療標的となる可能性を提案できる。
|
Report
(2 results)
Research Products
(8 results)
-
-
-
[Journal Article] Epithelial TRAF6 drives IL-17?mediated psoriatic inflammation2018
Author(s)
Matsumoto Reiko、Dainichi Teruki、Tsuchiya Soken、Nomura Takashi、Kitoh Akihiko、Hayden Matthew S.、Ishii Ken J.、Tanaka Mayuri、Honda Tetsuya、Egawa Gyohei、Otsuka Atsushi、Nakajima Saeko、Sakurai Kenji、Nakano Yuri、Kobayashi Takashi、Sugimoto Yukihiko、Kabashima Kenji
-
Journal Title
JCI Insight
Volume: 3
Issue: 15
Pages: 1-14
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
-
[Presentation] Topical p38 MAPK Activation Induces Psoriatic Dermatitis2019
Author(s)
Kenji Sakurai, Teruki Dainichi, Sandra Garcet, Soken Tsuchiya, Yoichiro Iwakura, Sankar Ghosh, Yukihiko Sugimoto, Emma Guttman-Yassky, James G. Krueger, Kenji Kabashima
Organizer
Keystone Simposia, Skin Health and Disease: Immune, Epithelial and Microbiome Crosstalk (D4), Hannover, Germany
Related Report
Int'l Joint Research
-