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Pathogenesis of Chronic Skin Ulcers by anti-HLA Class II/Misfolded Protein Complex Antibodies

Research Project

Project/Area Number 18K08296
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53050:Dermatology-related
Research InstitutionOsaka University

Principal Investigator

Arase Noriko  大阪大学, 大学院医学系研究科, 助教 (30360481)

Project Period (FY) 2018-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords抗Ro52/IgG/HLA-クラスII複合体抗体 / Ro52 / 皮膚筋炎 / 抗MDA5抗体 / 抗合成酵素抗体 / Ro52/IgG/HLA-クラスII複合体 / 抗MDA5抗体陽性無筋炎型皮膚筋炎 / 抗合成酵素抗体症候群 / KL-6 / 皮膚潰瘍 / 抗ARS抗体症候群 / 間質性肺炎 / 筋症状 / 細胞質内蛋白 / HLA Class II / ミスフォールド蛋白 / β2GPI / 自己免疫 / 自己免疫疾患 / HLA-DR / 抗リン脂質抗体症候群 / 自己抗体
Outline of Final Research Achievements

We found that the misfolded protein/HLA class II complex is transported to the cell surface and autoantibodies against the complex are produced in various connective tissue diseases. We have discovered that Ro52 forms a complex with IgG/HLA class II and is transported to the cell surface. This anti-Ro52/IgG/HLA-class II complex antibody was positive in about 90% of patients with anti-MDA5 antibody-positive dermatomyositis which are prone to skin ulceration, and anti-synthetase antibody syndrome sera. Changes in antibody titers of the complex antibodies were associated with changes in disease status, suggesting that this complex may have pathogenic roles.

Academic Significance and Societal Importance of the Research Achievements

原因不明の慢性皮膚潰瘍は患者のQOLが極めて低く、皮膚科医にとっても治療に難渋する疾患の一つである。私たちは以前原因不明の慢性皮膚潰瘍患者の約3割で抗リン脂質抗体症候群のサブタイプの抗β2GPI/HLA-DR抗体が陽性であることを発見した。今回それらに加えて皮膚潰瘍を作りやすい抗MDA5抗体陽性皮膚筋炎患者で新たに抗Ro52/IgG/HLA-DR抗体が陽性となることを見出した。これらの新たな自己抗体の病原性を明らかにすることは学術的に重要で、これらに関連した治療法を開発することは社会的意義がある。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (69 results)

All 2023 2022 2021 2020 2019 2018 2017

All Journal Article (46 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 46 results,  Open Access: 24 results,  Acknowledgement Compliant: 1 results) Presentation (22 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] 59.Age distribution and prevalence in different age groups of four myositis-specific autoantibodies, including anti-ARS, anti-MDA5, anti-Mi-2, and anti-TIF1γ antibodies2023

    • Author(s)
      Ueda-Hayakawa I, Tonomura K, Maekawa A, Kaneda E, Arase N, M Fujimoto M
    • Journal Title

      J Dermatol.

      Volume: - Issue: 8 Pages: 1058-1062

    • DOI

      10.1111/1346-8138.16772

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 58.A case of erosive pustular dermatosis of the scalp following bullous pemphigoid in a hematopoietic stem cell transplant recipient2023

    • Author(s)
      Yamashita C, Arase N, Fukushima K, Ueda-Hayakawa I, Tonomura K, Tanemura A, Sakai H, Fujimoto M
    • Journal Title

      J Dermatol.

      Volume: - Issue: 7

    • DOI

      10.1111/1346-8138.16743

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Aggressive Squamous Cell Carcinoma in a Case of Epidermodysplasia Verruciformis Carrying a TMC6 Splice-site Mutation2023

    • Author(s)
      Yokoi Kazunori、Arase Noriko、Shimbo Takashi、Fujimoto Manabu、Tanemura Atsushi
    • Journal Title

      Acta Dermato-Venereologica

      Volume: 103 Pages: 4550-4550

    • DOI

      10.2340/actadv.v103.4550

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mitigating Drug Target Drug Complexes in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Switch C5 Inhibitors2023

    • Author(s)
      Nishimura Jun‐ichi、Soubret Antoine、Arase Noriko、et al.
    • Journal Title

      Clinical Pharmacology & Therapeutics

      Volume: 113 Issue: 4 Pages: 904-915

    • DOI

      10.1002/cpt.2851

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Blistering Papulosquamous Erythema with Arthralgia: A Quiz.2022

    • Author(s)
      [Yukiho Kurosaki,Yosuke Ishitsuka,Yasuhiro Kato,Noriko Arase,Manabu Fujiomto]
    • Journal Title

      Acta dermato-venereologica

      Volume: 102 Pages: adv00690-adv00690

    • DOI

      10.2340/actadv.v102.936

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Familial Michelin tire baby syndrome.2022

    • Author(s)
      [Mami Hayashi,Mari Wataya-Kaneda,Hanako Koguchi-Yoshioka,Noriko Arase,Tateki Kubo,Hajime Nakano,Manabu Fujimoto]
    • Journal Title

      The Journal of dermatology

      Volume: - Issue: 7

    • DOI

      10.1111/1346-8138.16346

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules.2022

    • Author(s)
      [Hui Jin,Kazuki Kishida,Noriko Arase,Sumiko Matsuoka,Wataru Nakai,Masako Kohyama,Tadahiro Suenaga,Ken Yamamoto,Takehiko Sasazuki,Hisashi Arase]
    • Journal Title

      Science advances

      Volume: 8 Issue: 9

    • DOI

      10.1126/sciadv.abj9867

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum autoantibodies against the extracellular region of α6β4 integrin in a patient with dipeptidyl peptidase-4 inhibitor?induced bullous pemphigoid2022

    • Author(s)
      Yamashita Chigusa、Arase Noriko、Higuchi Shuhei、Arase Hisashi、Takagi Junichi、Nojima Satoshi、Tanemura Atsushi、Fujimoto Manabu
    • Journal Title

      JAAD Case Reports

      Volume: 20 Pages: 65-68

    • DOI

      10.1016/j.jdcr.2021.12.021

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Case of Pretibial Epidermolysis Bullosa with Novel Mutations of the COL7A1 Gene.2022

    • Author(s)
      [Yuri Shimizu,Yorihisa Kotobuki,Noriko Arase,Hisashi Arase,Ichiro Katayama,Manabu Fujimoto]
    • Journal Title

      Annals of dermatology

      Volume: 34 Issue: 1 Pages: 81-83

    • DOI

      10.5021/ad.2022.34.1.81

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies.2022

    • Author(s)
      [Noriko Arase,Hideaki Tsuji,Hyota Takamatsu,Hui Jin,Hachiro Konaka,Yasuhito Hamaguchi,Kyoko Tonomura,Yorihisa Kotobuki,Ikuko Ueda-Hayakawa,Sumiko Matsuoka,Toru Hirano,Hideki Yorifuji,Hiroyuki Murota,Koichiro Ohmura,Ran Nakashima,Tomoharu Sato,Atsushi Kumanogoh,Ichiro Katayama,Hisashi Arase,Manabu Fujimoto]
    • Journal Title

      Journal of autoimmunity

      Volume: 126 Pages: 102774-102774

    • DOI

      10.1016/j.jaut.2021.102774

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corrigendum to "Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies" [J. Autoimmun. 126 (2022) 102774].2022

    • Author(s)
      [Noriko Arase,Hideaki Tsuji,Hyota Takamatsu,Hui Jin,Hachiro Konaka,Yasuhito Hamaguchi,Kyoko Tonomura,Yorihisa Kotobuki,Ikuko Ueda-Hayakawa,Sumiko Matsuoka,Toru Hirano,Hideki Yorifuji,Hiroyuki Murota,Koichiro Ohmura,Ran Nakashima,Tomoharu Sato,Atsushi Kumanogoh,Ichiro Katayama,Hisashi Arase,Manabu Fujimoto]
    • Journal Title

      Journal of autoimmunity

      Volume: 127 Pages: 102797-102797

    • DOI

      10.1016/j.jaut.2022.102797

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myxovirus resistance protein 1-expressing fatal myocarditis in a patient with anti-MDA5 antibody-positive dermatomyositis.2021

    • Author(s)
      [Rika Sakamoto,Yorihisa Kotobuki,Saki Iga,Satoshi Nojima,Rikako Deno,Yuma Hanaoka,Kyoko Tonomura,Eiji Kiyohara,Yukinobu Nakagawa,Ikuko Ueda-Hayakawa,Noriko Arase,Manabu Fujimoto]
    • Journal Title

      Rheumatology (Oxford, England)

      Volume: 60 Issue: 12 Pages: e450-e452

    • DOI

      10.1093/rheumatology/keab637

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A pediatric case of cellulitis caused by Stenotrophomonas maltophilia with microvascular thrombosis and diffuse subcutaneous hemorrhage2021

    • Author(s)
      [Emi Inoue,Noriko Arase,Takako Miyamura,Tomohiro Wataya,Yusuke Tanaka,Nobuo Kashiwagi,Hiroshi Sakai,Satoshi Nojima,Manabu Fujimoto]
    • Journal Title

      Journal of Cutaneous Immunology and Allergy

      Volume: 4 Issue: 6 Pages: 181-183

    • DOI

      10.1002/cia2.12197

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies2021

    • Author(s)
      Liu Y, Ohshima S, Arase H, et al.
    • Journal Title

      Cell

      Volume: Jun 24;184(13) Issue: 13 Pages: 3452-3466

    • DOI

      10.1016/j.cell.2021.05.032

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti?Double‐Stranded DNA Antibodies Recognize DNA Presented on HLA Class II Molecules of Systemic Lupus Erythematosus Risk Alleles2021

    • Author(s)
      Tsuji Hideaki、Ohmura Koichiro、Jin Hui、Naito Ryota、Arase Noriko、Kohyama Masako、Suenaga Tadahiro、Sakakibara Shuhei、Kochi Yuta、Okada Yukinori、Yamamoto Kazuhiko、Kikutani Hitoshi、Morinobu Akio、Mimori Tsuneyo、Arase Hisashi
    • Journal Title

      Arthritis & Rheumatology

      Volume: 74 Issue: 1 Pages: 105-111

    • DOI

      10.1002/art.41897

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunohistopathological observation of a case recovering from leukotrichia after suction blister transplantation2021

    • Author(s)
      [Atsushi Tanemura,Hanako Koguchi-Yoshioka,Kazunori Yokoi,Eiji Kiyohara,Noriko Arase,Rintaro Ohe,Tamio Suzuki,Manabu Fujimoto]
    • Journal Title

      JOURNAL OF DERMATOLOGY

      Volume: in press Issue: 6

    • DOI

      10.1111/1346-8138.15855

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unilateral heliotrope rash: a warning sign for anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis.2021

    • Author(s)
      Kume M, Arase N, Okiyama N, Koguchi-Yoshioka H, Tada T, Saruban H, Fujimoto M.
    • Journal Title

      Rheumatology (Oxford)

      Volume: 60(4) Issue: 4 Pages: e134-e135

    • DOI

      10.1093/rheumatology/keaa574

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Large-scale plasma-metabolome analysis identifies potential biomarkers of psoriasis and its clinical subtypes2021

    • Author(s)
      Kishikawa Toshihiro、Arase Noriko、Tsuji Shigeyoshi、Maeda Yuichi、Nii Takuro、Hirata Jun、Suzuki Ken、Yamamoto Kenichi、Masuda Tatsuo、Ogawa Kotaro、Ohshima Shiro、Inohara Hidenori、Kumanogoh Atsushi、Fujimoto Manabu、Okada Yukinori
    • Journal Title

      Journal of Dermatological Science

      Volume: 102 Issue: 2 Pages: 78-84

    • DOI

      10.1016/j.jdermsci.2021.03.006

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A rare case of multiple pyoderma gangrenosum co-mobilized with pseudoxanthoma elasticum2021

    • Author(s)
      [Saki Iga,Atsushi Tanemura,Takumi Kamitani,Madoka Takafuji,Yuma Hanaoka,Noriko Arase,Manabu Fujimoto]
    • Journal Title

      JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY

      Volume: 4 Issue: 3 Pages: 71-72

    • DOI

      10.1002/cia2.12159

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A NOVEL AUTOANTIBODY AGAINST beta 2-GLYCOPROTEIN I/HLA CLASS II COMPLEXES IS A MAJOR RISK FACTOR FOR RECURRENT PREGNANCY LOSS2021

    • Author(s)
      [Kenji Tanimura,Shigeru Saito,Mikiya Nakatsuka,Takeshi Nagamatsu,Tomoyuki Fujii,Atsushi Fukui,Yuki Sasagawa,Masashi Deguchi,Noriko Arase,Hisashi Arase,Hideto Yamada]
    • Journal Title

      PLACENTA

      Volume: 103 Pages: 253-254

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Use of a combination of oral psoralen, ultraviolet A and interferon-gamma for the treatment of mycosis fungoides during pregnancy, which probably evoked CD8(+)CD30(+)lymphoproliferative disorder2021

    • Author(s)
      [Kyoko Tonomura,Eiji Kiyohara,Yuya Nakanishi,Atsushi Tanemura,Noriko Arase,Yukinobu Nakagawa,Manabu Fujimoto]
    • Journal Title

      JOURNAL OF DERMATOLOGY

      Volume: 48 Issue: 1

    • DOI

      10.1111/1346-8138.15628

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The beneficial effect of a PDE4 inhibitor in a patient with juvenile-onset intractable pityriasis rubra pilaris without CARD14 mutation2021

    • Author(s)
      [Emi Inoue,Noriko Arase,Yuma Hanaoka,Atsushi Tanemura,Manabu Fujimoto]
    • Journal Title

      DERMATOLOGIC THERAPY

      Volume: 34 Issue: 1

    • DOI

      10.1111/dth.14714

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Increased levels of plasma nucleotides in patients with rheumatoid arthritis2020

    • Author(s)
      Kishikawa T、Maeda Y、Nii T、Arase N、Hirata J、Suzuki K、Yamamoto K、Masuda T、Ogawa K、Tsuji S、Matsushita M、Matsuoka H、Yoshimura M、Tsunoda S、Ohshima S、Narazaki M、Ogata A、Saeki Y、Inohara H、Kumanogoh A、Takeda K、Okada Y
    • Journal Title

      International Immunology

      Volume: 33 Issue: 2 Pages: 119-124

    • DOI

      10.1093/intimm/dxaa059

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Local and disease control for nasal melanoma treated with radiation and concomitant anti‐programmed death 1 antibody2020

    • Author(s)
      Hanaoka Yuma、Tanemura Atsushi、Takafuji Madoka、Kiyohara Eiji、Arase Noriko、Suzuki Osamu、Isohashi Fumiaki、Ogawa Kazuhiko、Fujimoto Manabu
    • Journal Title

      The Journal of Dermatology

      Volume: 47 Issue: 4 Pages: 423-425

    • DOI

      10.1111/1346-8138.15256

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of granuloma annulare after using tocilizumab2020

    • Author(s)
      [Kurumi Katsuda,Noriko Arase,Yukinobu Nakagawa,Atsushi Tanemura,Manabu Fujimoto]
    • Journal Title

      JOURNAL OF DERMATOLOGY

      Volume: 47 Issue: 4

    • DOI

      10.1111/1346-8138.15252

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Genotype and phenotype analysis of patients with pediatric cutaneous mastocytosis, especially wild‐type KIT patients2020

    • Author(s)
      Arase Noriko、Wataya‐Kaneda Mari、Murota Hiroyuki、Nakagawa Yukinobu、Yamaoka Toshifumi、Itoi‐Ochi Saori、Hirayasu Kouyuki、Arase Hisashi、Fujimoto Manabu、Katayama Ichiro
    • Journal Title

      The Journal of Dermatology

      Volume: 47 Issue: 4 Pages: 426-429

    • DOI

      10.1111/1346-8138.15266

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure2020

    • Author(s)
      Kume Miki、Nakagawa Yukinobu、Kiyohara Eiji、Arase Noriko、Wataya-Kaneda Mari、Yaga Moto、Yanagawa Masahiro、Fujimoto Manabu
    • Journal Title

      Allergology International

      Volume: 20 Issue: 4 Pages: 30057-5

    • DOI

      10.1016/j.alit.2020.04.007

    • NAID

      130007926229

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rare case of segmental vitiligo in which lesional enlargement occurred after suction blister transplantation2020

    • Author(s)
      [Kurumi Katsuda,Atsushi Tanemura,Madoka Takafuji,Yuma Hanaoka,Eiji Kiyohara,Noriko Arase,Manabu Fujimoto]
    • Journal Title

      JOURNAL OF DERMATOLOGY

      Volume: 47 Issue: 9

    • DOI

      10.1111/1346-8138.15489

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical analysis of rhododendrol-induced leukoderma in improved and aggravated cases2020

    • Author(s)
      [Masahito Yasuda,Akiko Sekiguchi,Chikako Kishi,Sayaka Toki,Noriko Arase,Aya Takahashi,Fei Yang,Atsushi Tanemura,Masahiro Hayashi,Yuko Abe,Toshihisa Hamada,Tamio Suzuki,Ichiro Katayama,Osamu Ishikawa]
    • Journal Title

      JOURNAL OF DERMATOLOGICAL SCIENCE

      Volume: 99 Issue: 2 Pages: 140-143

    • DOI

      10.1016/j.jdermsci.2020.06.011

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The beta(2)-Glycoprotein I/HLA-DR Complex As A Major Autoantibody Target in Obstetric Antiphospholipid Syndrome2020

    • Author(s)
      [Kenji Tanimura,Shigeru Saito,Mikiya Nakatsuka,Takeshi Nagamatsu,Tomoyuki Fujii,Atsushi Fukui,Masashi Deguchi,Yuki Sasagawa,Noriko Arase,Hisashi Arase,Hideto Yamada]
    • Journal Title

      ARTHRITIS & RHEUMATOLOGY

      Volume: 72 Issue: 11 Pages: 1882-1891

    • DOI

      10.1002/art.41410

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The first case of symmetrical acral keratoderma in Japan with filaggrin mutation who showed marked improvement in skin manifestations using moisturizer.2020

    • Author(s)
      Kazuya Akaji, Noriko Arase, Jin Teng Peh, Eiji Kiyohara, Hiroyuki Murota, Toshifumi Nomura, Manabu Fujimoto
    • Journal Title

      The Journal of Dermatology

      Volume: in press Issue: 8

    • DOI

      10.1111/1346-8138.15410

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Achievement of remission with surgical resection of a lung adenocarcinoma without systemic treatment in a rare case of anti-TIF1-gamma antibody-positive dermatomyositis2020

    • Author(s)
      [Kyoko Tonomura,Yorihisa Kotobuki,Soichiro Funaki,Kurumi Katsuda,Noriko Arase,Eiji Kiyohara,Ikuko Ueda,Manabu Fujimoto]
    • Journal Title

      JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY

      Volume: 3 Issue: 5 Pages: 117-119

    • DOI

      10.1002/cia2.12134

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] An Optimized Crovalimab Dose and Regimen Reduced the Formation of Drug-Target-Drug Complexes in Patients with Paroxysmal Nocturnal Hemoglobinuria from the Phase I/II COMPOSER Trial2020

    • Author(s)
      [Jun-Ichi Nishimura,Antoine Soubret,Simon Buatois,Jean-Eric Charoin,Sasha Sreckovic,Christoph Bucher,Jules Hernandez-Sanchez,Gregor Jordan,Julia Ramos,Noriko Arase,Masaki Hotta,Yoshitaka Isaka,Yoshikazu Ito,Yuzuru Kanakura,Jin Seok Kim,Taroh Kinoshita,Eiichi Morii,et.al.]
    • Journal Title

      BLOOD

      Volume: 136 Issue: Supplement 1 Pages: 2-3

    • DOI

      10.1182/blood-2020-136265

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Case of X‐linked hypohidrotic ectodermal dysplasia, along with facial bilateral reticular pigmentation2020

    • Author(s)
      Kamitani Tomo、Arase Noriko、Nomura Toshifumi、Peh Jin Teng、Katayama Ichiro、Wataya‐Kaneda Mari、Fujimoto Manabu
    • Journal Title

      Journal of Cutaneous Immunology and Allergy

      Volume: 3 Issue: 2 Pages: 41-42

    • DOI

      10.1002/cia2.12097

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of giant porokeratosis coexisting disseminated superficial porokeratosis2020

    • Author(s)
      [Saori Itoi-Ochi,Atsushi Tanemura,Noriko Arase,Manabu Fujimoto]
    • Journal Title

      JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY

      Volume: 3 Issue: 6 Pages: 139-141

    • DOI

      10.1002/cia2.12141

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A case of drug‐induced hypersensitivity syndrome due to diaminodiphenyl sulfone complicated by acute respiratory failure with atypical erythema around existing prurigo2020

    • Author(s)
      Akaji Kazuya、Arase Noriko、Nakagawa Yukinobu、Tanemura Atsushi、Katayama Ichiro、Fujimoto Manabu
    • Journal Title

      Journal of Cutaneous Immunology and Allergy

      Volume: 3 Issue: 2 Pages: 45-47

    • DOI

      10.1002/cia2.12106

    • Related Report
      2020 Research-status Report 2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus2020

    • Author(s)
      Kabashima K, Matsumura T, Komazaki H, Kawashima M; Nemolizumab-JP01 Study Group.
    • Journal Title

      N Engl J Med.

      Volume: 383 Issue: 2 Pages: 141-150

    • DOI

      10.1056/nejmoa1917006

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Asian Case of Metastatic Melanoma in Which a Complete Response Was Maintained after Discontinuation of Dabrafenib and Trametinib2020

    • Author(s)
      Rikako Deno, Atsushi Tanemura, Madoka Takefuji, Yuma Hanaoka, Eiji Kiyohara, Noriko Arase, Mari Wataya-Kaneda, Manabu Fujimoto
    • Journal Title

      Journal of Cosmetics, Dermatological Sciences and Applications

      Volume: 10

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure2020

    • Author(s)
      Kume, Miki, Nakagawa, Yukinobu, Kiyohara, Eiji, Arase, Noriko, KANEDA, MARI, Yaga, Moto, Yanagawa, Masahiro, Fujimoto, Manabu
    • Journal Title

      Allergology International

      Volume: in press

    • NAID

      130007926229

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression of polydom in dermal neurofibroma and surrounding dermis in von Recklinghausen’s disease2019

    • Author(s)
      Kamitani Tomo、Murota Hiroyuki、Arase Noriko、Wataya-Kaneda Mari、Sato-Nishiuchi Ryoko、Sekiguchi Kiyotoshi、Okuzaki Daisuke、Motooka Daisuke、Katayama Ichiro
    • Journal Title

      Journal of Dermatological Science

      Volume: 96 Issue: 2 Pages: 73-80

    • DOI

      10.1016/j.jdermsci.2019.09.005

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case of epidermolytic ichthyosis with impairment of pulmonary function and exacerbated skin manifestations in a late middle‐aged adult2019

    • Author(s)
      Maekawa Aya、Arase Noriko、Tamai Katsuto、Nomura Toshifumi、Kiyohara Eiji、Wataya‐Kaneda Mari、Arase Hisashi、Katayama Ichiro、Fujimoto Manabu
    • Journal Title

      The Journal of Dermatology

      Volume: 46 Issue: 12 Pages: 480-482

    • DOI

      10.1111/1346-8138.15077

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rare case of Leydig cell tumor with type I diabetes mellitus causing female pattern hair loss2019

    • Author(s)
      Fukuda Miki、Arase Noriko、Otsuki Michio、Kuritani Kentaro、Hijiki Sachiko、Nojima Satoshi、Katayama Ichiro、Terao Mika、Inui Shigeki、Fujimoto Manabu
    • Journal Title

      The Journal of Dermatology

      Volume: 46 Issue: 12

    • DOI

      10.1111/1346-8138.15050

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Autoantibodies detected in patients with vitiligo vulgaris but not in those with rhododendrol-induced leukoderma2019

    • Author(s)
      Arase Noriko,Tanemura Atsushi,Jin Hui,Nishioka Megumi,Aoyama Yumi,Oiso Naoki,Matsunaga Kayoko,Suzuki Tamio,Nishigori Chikako,Kawamura Tatsuyoshi,Shimizu Tadamichi,Ito Akiko,Fukai Kazuyoshi,Abe Yuko,Yang Lingli,Tsuruta Daisuke,et al
    • Journal Title

      Journal of Dermatological Science

      Volume: 95 Issue: 2 Pages: 80-83

    • DOI

      10.1016/j.jdermsci.2019.06.009

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain.2019

    • Author(s)
      Yorifuji H, Arase N, Kohyama M, Hirano T, Suenaga T, Kumanogoh A, Arase H.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 511 Issue: 4 Pages: 862-868

    • DOI

      10.1016/j.bbrc.2019.02.120

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules.2019

    • Author(s)
      Shimizu Y, Kohyama M, Yorifuji H, Jin H, Arase N, Suenaga T, Arase H.
    • Journal Title

      Int Immunol.

      Volume: Epub ahead of print Issue: 5 Pages: 303-314

    • DOI

      10.1093/intimm/dxz010

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel autoantibody against the β2-glycoprotein I/HLA-DR complex in patients with refractory cutaneous ulcers2017

    • Author(s)
      Arase N, Tanimura K, Jin H, Yamaoka T, Kishibe M, Nishioka M, Kiyohara E, Tani M, Matsuoka S, Ohmura K, Takasugi K, Yamamoto T, Murota H, Arase H, Katayama I.
    • Journal Title

      Br J Dermatol.

      Volume: 印刷中 Issue: 1 Pages: 272-275

    • DOI

      10.1111/bjd.15571

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 抗MDA5抗体陽性皮膚筋炎の加療中に皮膚腺病を発症した1例2023

    • Author(s)
      秦野暢子、外村香子、木原俊輔、浅田充夫、山下千佳紗、石塚洋典、荒瀬規子、植田郁子、種村篤、藤本学、平田陽彦、五十嵐謙人、山本剛、木村優香、片岡葉子
    • Organizer
      第496回大阪地方会
    • Related Report
      2022 Annual Research Report
  • [Presentation] TMC6に変異を認め進行有棘細胞癌を生じた疣贅状表皮発育異常症の1例2022

    • Author(s)
      藤本 萌、横井一範、黒神 祐、外村香子、荒瀬規子、種村 篤、藤本 学、新保敬史、玉井克人
    • Organizer
      第73回皮膚科学会中部支部
    • Related Report
      2022 Annual Research Report
  • [Presentation] 造血幹細胞移植後に生じたerosive pustular dermatosis of the scalpの1例2022

    • Author(s)
      山下千佳紗、荒瀬規子、坂井浩志、藤本 学
    • Organizer
      日本皮膚科学会 第115回近畿皮膚科集談会
    • Related Report
      2022 Annual Research Report
  • [Presentation] DPP-4阻害薬服用中に発症した抗α6β4インテグリン抗体陽性水疱性類天疱瘡の1例2021

    • Author(s)
      山下千佳紗、荒瀬規子、種村篤、野島聡、藤本学
    • Organizer
      第51回日本皮膚免疫アレルギー学会総会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] An infectivity-enhancing site on the SARS-Cov-2 spike protein targeted by antibodies2021

    • Author(s)
      Yafei Liu, Wataru Nakai, Noriko Arase, Masako Kohyama, Hisashi Arase
    • Organizer
      The 50th Annual Meeting of The Japanese Society for Immunology
    • Related Report
      2021 Research-status Report
  • [Presentation] Plasma metabolome-wide analysis in Japanese identifies potential biomarkers of psoriasis and clinical subtypes2021

    • Author(s)
      Yukinori Okada, Toshihiro Kishikawa, Noriko Arase, Shigeyoshi Tsuji, Yuichi Maeda, Takuro Nii, Jun Hirata, Ken Suzuki, Kenichi Yamamoto, Shiro Ohshima, Hidenori Inohara, Atsushi Kumanogoh, Manabu Fujimoto
    • Organizer
      The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
    • Related Report
      2021 Research-status Report
  • [Presentation] ヘパリン類似物質が奏功した symmetrical acral keratoderma の1例2020

    • Author(s)
      赤路和哉、荒瀬規子、Peh Jin Teng、清原英司、室田浩之、乃村俊史、藤本 学
    • Organizer
      第84回日本皮膚科学会東部支部学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] アプレミラストが奏効した若年性毛孔性紅色粃糠疹の1例2020

    • Author(s)
      井上栄美、荒瀬規子、花岡佑真、種村 篤、藤本 学
    • Organizer
      第84回日本皮膚科学会東京支部学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] An Optimized Crovalimab Dose and Regimen Reduced the Formation of Drug-Target-Drug Complexes in Patients with Paroxysmal Nocturnal Hemoglobinuria From the Phase I/II COMPOSER Trial.2020

    • Author(s)
      Jun-ichi Nishimura, Antoine Soubret, Simon Buatois, Jean-Eric Charoin, Sasha Sreckovic, Christoph Bucher, Jules Hernandez-Sanchez, Gregor Jordan, Julia Ramos, Noriko Arase, Masaki Hotta, Yoshitaka Isaka, Yoshikazu Ito, Yuzuru Kanakura, Jin Seok Kim, Taroh Kinoshita, Eiichi Morii, et.al.
    • Organizer
      62nd Ash Annual Meeting and Exposition
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 視神経脊髄炎に対してトシリズマブ使用後に環状肉芽腫を発症した1例2019

    • Author(s)
      勝田来未、荒瀬規子、中川幸延、種村 篤、藤本 学
    • Organizer
      第71回日本皮膚科学会西部支部学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 結節性痒疹治療中に急性呼吸不全を呈したDIHSの一例2019

    • Author(s)
      赤路 和哉、荒瀬 規子、中川 幸延、片山 一朗、藤本 学
    • Organizer
      第49回日本皮膚免疫アレルギー学会総会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] 呼吸障害を併発したゾニサミドによる中毒性表皮壊死症の1例2019

    • Author(s)
      福田美輝、中川幸延、清原英司、 荒瀬規子、金田眞理、藤本学
    • Organizer
      第49回日本皮膚免疫アレルギー学会総会学術大会
    • Related Report
      2019 Research-status Report
  • [Presentation] ミスフォールド蛋白質/MHCクラスII複合体2019

    • Author(s)
      荒瀬規子
    • Organizer
      第47回日本臨床免疫学会総会
    • Related Report
      2019 Research-status Report
    • Invited
  • [Presentation] Analysis of autoantibody against Ro52/IgG/HLA-DR complex in patients with Dermatomyositis2019

    • Author(s)
      Noriko Arase, Kaori Odomari, Yorihisa Kotobuki, Hideaki Tsuji, Ran Sasai, Toru Hirano, Hideki Yorifuji, Kyoko Tonomura, Ichiro Katayama, Hiroyuki Murota, Hui Jin, Koichiro Ohmura, Atsushi Kumanogoh, Hisashi Arase, Manabu Fujimoto
    • Organizer
      日本研究皮膚科学会 第44回年次学術大会・総会
    • Related Report
      2019 Research-status Report
  • [Presentation] Female pattern hair loss (FPHL)を呈した1型糖尿病合併ライディッヒ細胞腫の1例2019

    • Author(s)
      福田美輝、荒瀬規子、片山一朗、寺尾美香、乾重樹、藤本学
    • Organizer
      第24回日本臨床毛髪学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] MHCクラスⅡ分子によるDNAの提示2019

    • Author(s)
      辻 英輝、大村 浩一郎、荒瀬 規子、香山 雅子、榊原 修平、菊谷 仁、末永 忠広、三森 経世、荒瀬 尚
    • Organizer
      第29 回Kyoto T cell Conference
    • Related Report
      2019 Research-status Report
  • [Presentation] TSHR / MHC class II complexes are involved in the pathogenesis of Graves' disease2019

    • Author(s)
      Hui Jin, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Takehiko Sasazuki, Hisashi Arase
    • Organizer
      第18回あわじ感染と免疫フォーラム
    • Related Report
      2019 Research-status Report
  • [Presentation] FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules2019

    • Author(s)
      Tadahiro Suenaga, Yuta Shimizu, Masako Kohyama, Hideki Yorifuji, Jin Hui, Noriko Arase, Hisashi Arase
    • Organizer
      第48回日本免疫学会学術集会
    • Related Report
      2019 Research-status Report
  • [Presentation] 大阪大学皮膚科における皮膚肥満細胞増多症16症例の解析2018

    • Author(s)
      荒瀬規子 金田眞理 室田浩之 中川幸延 山岡俊文 平安恒幸 荒瀬 尚 片山一朗
    • Organizer
      日本皮膚科学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] 壮年期に肺機能障害を伴い皮疹が悪化 した表皮融解性魚鱗癬に関する考察2018

    • Author(s)
      前川亜耶 荒瀬規子 清原英司 玉井克人 片山一朗 金田眞理
    • Organizer
      日本皮膚科学会東部支部学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] Recognition of DNA/HLA-class II complex by anti-DNA antibodies from SLE patients2018

    • Author(s)
      Hideki Tsuji, Koichiro Ohmura, Shuhei Sakakibara, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Hitoshi Kikutani, Tsuneyo Mimori, Hisashi Arase
    • Organizer
      日本免疫学会学術集会
    • Related Report
      2018 Research-status Report
  • [Presentation] TSHR-stimulating autoantibody production by TSHR/MHC class II complexes2018

    • Author(s)
      Hui Hin, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Takehiko Sasazuki, Hisashi Arase
    • Organizer
      日本免疫学会学術集会
    • Related Report
      2018 Research-status Report
  • [Book] 皮膚科 ベストセレクション 皮膚科 膠原病2021

    • Author(s)
      荒瀬規子、荒瀬尚
    • Total Pages
      515
    • Publisher
      中山書店
    • ISBN
      9784521748627
    • Related Report
      2021 Research-status Report

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Published: 2018-04-23   Modified: 2024-01-30  

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