Pathogenesis of Chronic Skin Ulcers by anti-HLA Class II/Misfolded Protein Complex Antibodies

• Project/Area Number: 18K08296
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Osaka University
• Principal Investigator: Arase Noriko 大阪大学, 大学院医学系研究科, 助教 (30360481)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 抗Ro52/IgG/HLA-クラスII複合体抗体 / Ro52 / 皮膚筋炎 / 抗MDA5抗体 / 抗合成酵素抗体 / Ro52/IgG/HLA-クラスII複合体 / 抗MDA5抗体陽性無筋炎型皮膚筋炎 / 抗合成酵素抗体症候群 / KL-6 / 皮膚潰瘍 / 抗ARS抗体症候群 / 間質性肺炎 / 筋症状 / 細胞質内蛋白 / HLA Class II / ミスフォールド蛋白 / β2GPI / 自己免疫 / 自己免疫疾患 / HLA-DR / 抗リン脂質抗体症候群 / 自己抗体

Outline of Final Research Achievements

We found that the misfolded protein/HLA class II complex is transported to the cell surface and autoantibodies against the complex are produced in various connective tissue diseases. We have discovered that Ro52 forms a complex with IgG/HLA class II and is transported to the cell surface. This anti-Ro52/IgG/HLA-class II complex antibody was positive in about 90% of patients with anti-MDA5 antibody-positive dermatomyositis which are prone to skin ulceration, and anti-synthetase antibody syndrome sera. Changes in antibody titers of the complex antibodies were associated with changes in disease status, suggesting that this complex may have pathogenic roles.

Academic Significance and Societal Importance of the Research Achievements

原因不明の慢性皮膚潰瘍は患者のQOLが極めて低く、皮膚科医にとっても治療に難渋する疾患の一つである。私たちは以前原因不明の慢性皮膚潰瘍患者の約３割で抗リン脂質抗体症候群のサブタイプの抗β2GPI/HLA-DR抗体が陽性であることを発見した。今回それらに加えて皮膚潰瘍を作りやすい抗MDA5抗体陽性皮膚筋炎患者で新たに抗Ro52/IgG/HLA-DR抗体が陽性となることを見出した。これらの新たな自己抗体の病原性を明らかにすることは学術的に重要で、これらに関連した治療法を開発することは社会的意義がある。

Research Products

• [Journal Article] 59.Age distribution and prevalence in different age groups of four myositis-specific autoantibodies, including anti-ARS, anti-MDA5, anti-Mi-2, and anti-TIF1γ antibodies (2023)
  • Author(s): Ueda-Hayakawa I, Tonomura K, Maekawa A, Kaneda E, Arase N, M Fujimoto M
  • Journal Title: J Dermatol. Volume: - Issue: 8 Pages: 1058-1062
  • DOI: 10.1111/1346-8138.16772
  • Peer Reviewed
• [Journal Article] 58.A case of erosive pustular dermatosis of the scalp following bullous pemphigoid in a hematopoietic stem cell transplant recipient (2023)
  • Author(s): Yamashita C, Arase N, Fukushima K, Ueda-Hayakawa I, Tonomura K, Tanemura A, Sakai H, Fujimoto M
  • Journal Title: J Dermatol. Volume: - Issue: 7
  • DOI: 10.1111/1346-8138.16743
  • Peer Reviewed
• [Journal Article] Aggressive Squamous Cell Carcinoma in a Case of Epidermodysplasia Verruciformis Carrying a TMC6 Splice-site Mutation (2023)
  • Author(s): Yokoi Kazunori、Arase Noriko、Shimbo Takashi、Fujimoto Manabu、Tanemura Atsushi
  • Journal Title: Acta Dermato-Venereologica Volume: 103 Pages: 4550-4550
  • DOI: 10.2340/actadv.v103.4550
  • Peer Reviewed / Open Access
• [Journal Article] Mitigating Drug Target Drug Complexes in Patients With Paroxysmal Nocturnal Hemoglobinuria Who Switch C5 Inhibitors (2023)
  • Author(s): Nishimura Jun‐ichi、Soubret Antoine、Arase Noriko、et al.
  • Journal Title: Clinical Pharmacology & Therapeutics Volume: 113 Issue: 4 Pages: 904-915
  • DOI: 10.1002/cpt.2851
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Blistering Papulosquamous Erythema with Arthralgia: A Quiz. (2022)
  • Author(s): [Yukiho Kurosaki,Yosuke Ishitsuka,Yasuhiro Kato,Noriko Arase,Manabu Fujiomto]
  • Journal Title: Acta dermato-venereologica Volume: 102 Pages: adv00690-adv00690
  • DOI: 10.2340/actadv.v102.936
  • Peer Reviewed / Open Access
• [Journal Article] Familial Michelin tire baby syndrome. (2022)
  • Author(s): [Mami Hayashi,Mari Wataya-Kaneda,Hanako Koguchi-Yoshioka,Noriko Arase,Tateki Kubo,Hajime Nakano,Manabu Fujimoto]
  • Journal Title: The Journal of dermatology Volume: - Issue: 7
  • DOI: 10.1111/1346-8138.16346
  • Peer Reviewed
• [Journal Article] Abrogation of self-tolerance by misfolded self-antigens complexed with MHC class II molecules. (2022)
  • Author(s): [Hui Jin,Kazuki Kishida,Noriko Arase,Sumiko Matsuoka,Wataru Nakai,Masako Kohyama,Tadahiro Suenaga,Ken Yamamoto,Takehiko Sasazuki,Hisashi Arase]
  • Journal Title: Science advances Volume: 8 Issue: 9
  • DOI: 10.1126/sciadv.abj9867
  • Peer Reviewed / Open Access
• [Journal Article] Serum autoantibodies against the extracellular region of α6β4 integrin in a patient with dipeptidyl peptidase-4 inhibitor?induced bullous pemphigoid (2022)
  • Author(s): Yamashita Chigusa、Arase Noriko、Higuchi Shuhei、Arase Hisashi、Takagi Junichi、Nojima Satoshi、Tanemura Atsushi、Fujimoto Manabu
  • Journal Title: JAAD Case Reports Volume: 20 Pages: 65-68
  • DOI: 10.1016/j.jdcr.2021.12.021
  • Peer Reviewed / Open Access
• [Journal Article] A Case of Pretibial Epidermolysis Bullosa with Novel Mutations of the COL7A1 Gene. (2022)
  • Author(s): [Yuri Shimizu,Yorihisa Kotobuki,Noriko Arase,Hisashi Arase,Ichiro Katayama,Manabu Fujimoto]
  • Journal Title: Annals of dermatology Volume: 34 Issue: 1 Pages: 81-83
  • DOI: 10.5021/ad.2022.34.1.81
  • Peer Reviewed / Open Access
• [Journal Article] Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies. (2022)
  • Author(s): [Noriko Arase,Hideaki Tsuji,Hyota Takamatsu,Hui Jin,Hachiro Konaka,Yasuhito Hamaguchi,Kyoko Tonomura,Yorihisa Kotobuki,Ikuko Ueda-Hayakawa,Sumiko Matsuoka,Toru Hirano,Hideki Yorifuji,Hiroyuki Murota,Koichiro Ohmura,Ran Nakashima,Tomoharu Sato,Atsushi Kumanogoh,Ichiro Katayama,Hisashi Arase,Manabu Fujimoto]
  • Journal Title: Journal of autoimmunity Volume: 126 Pages: 102774-102774
  • DOI: 10.1016/j.jaut.2021.102774
  • Peer Reviewed / Open Access
• [Journal Article] Corrigendum to "Cell surface-expressed Ro52/IgG/HLA-DR complex is targeted by autoantibodies in patients with inflammatory myopathies" [J. Autoimmun. 126 (2022) 102774]. (2022)
  • Author(s): [Noriko Arase,Hideaki Tsuji,Hyota Takamatsu,Hui Jin,Hachiro Konaka,Yasuhito Hamaguchi,Kyoko Tonomura,Yorihisa Kotobuki,Ikuko Ueda-Hayakawa,Sumiko Matsuoka,Toru Hirano,Hideki Yorifuji,Hiroyuki Murota,Koichiro Ohmura,Ran Nakashima,Tomoharu Sato,Atsushi Kumanogoh,Ichiro Katayama,Hisashi Arase,Manabu Fujimoto]
  • Journal Title: Journal of autoimmunity Volume: 127 Pages: 102797-102797
  • DOI: 10.1016/j.jaut.2022.102797
  • Peer Reviewed / Open Access
• [Journal Article] Myxovirus resistance protein 1-expressing fatal myocarditis in a patient with anti-MDA5 antibody-positive dermatomyositis. (2021)
  • Author(s): [Rika Sakamoto,Yorihisa Kotobuki,Saki Iga,Satoshi Nojima,Rikako Deno,Yuma Hanaoka,Kyoko Tonomura,Eiji Kiyohara,Yukinobu Nakagawa,Ikuko Ueda-Hayakawa,Noriko Arase,Manabu Fujimoto]
  • Journal Title: Rheumatology (Oxford, England) Volume: 60 Issue: 12 Pages: e450-e452
  • DOI: 10.1093/rheumatology/keab637
  • Peer Reviewed / Open Access
• [Journal Article] A pediatric case of cellulitis caused by Stenotrophomonas maltophilia with microvascular thrombosis and diffuse subcutaneous hemorrhage (2021)
  • Author(s): [Emi Inoue,Noriko Arase,Takako Miyamura,Tomohiro Wataya,Yusuke Tanaka,Nobuo Kashiwagi,Hiroshi Sakai,Satoshi Nojima,Manabu Fujimoto]
  • Journal Title: Journal of Cutaneous Immunology and Allergy Volume: 4 Issue: 6 Pages: 181-183
  • DOI: 10.1002/cia2.12197
  • Peer Reviewed / Open Access
• [Journal Article] An infectivity-enhancing site on the SARS-CoV-2 spike protein targeted by antibodies (2021)
  • Author(s): Liu Y, Ohshima S, Arase H, et al.
  • Journal Title: Cell Volume: Jun 24;184(13) Issue: 13 Pages: 3452-3466
  • DOI: 10.1016/j.cell.2021.05.032
  • Peer Reviewed / Open Access
• [Journal Article] Anti?Double‐Stranded DNA Antibodies Recognize DNA Presented on HLA Class II Molecules of Systemic Lupus Erythematosus Risk Alleles (2021)
  • Author(s): Tsuji Hideaki、Ohmura Koichiro、Jin Hui、Naito Ryota、Arase Noriko、Kohyama Masako、Suenaga Tadahiro、Sakakibara Shuhei、Kochi Yuta、Okada Yukinori、Yamamoto Kazuhiko、Kikutani Hitoshi、Morinobu Akio、Mimori Tsuneyo、Arase Hisashi
  • Journal Title: Arthritis & Rheumatology Volume: 74 Issue: 1 Pages: 105-111
  • DOI: 10.1002/art.41897
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistopathological observation of a case recovering from leukotrichia after suction blister transplantation (2021)
  • Author(s): [Atsushi Tanemura,Hanako Koguchi-Yoshioka,Kazunori Yokoi,Eiji Kiyohara,Noriko Arase,Rintaro Ohe,Tamio Suzuki,Manabu Fujimoto]
  • Journal Title: JOURNAL OF DERMATOLOGY Volume: in press Issue: 6
  • DOI: 10.1111/1346-8138.15855
  • Peer Reviewed
• [Journal Article] Unilateral heliotrope rash: a warning sign for anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis. (2021)
  • Author(s): Kume M, Arase N, Okiyama N, Koguchi-Yoshioka H, Tada T, Saruban H, Fujimoto M.
  • Journal Title: Rheumatology (Oxford) Volume: 60(4) Issue: 4 Pages: e134-e135
  • DOI: 10.1093/rheumatology/keaa574
  • Peer Reviewed / Open Access
• [Journal Article] Large-scale plasma-metabolome analysis identifies potential biomarkers of psoriasis and its clinical subtypes (2021)
  • Author(s): Kishikawa Toshihiro、Arase Noriko、Tsuji Shigeyoshi、Maeda Yuichi、Nii Takuro、Hirata Jun、Suzuki Ken、Yamamoto Kenichi、Masuda Tatsuo、Ogawa Kotaro、Ohshima Shiro、Inohara Hidenori、Kumanogoh Atsushi、Fujimoto Manabu、Okada Yukinori
  • Journal Title: Journal of Dermatological Science Volume: 102 Issue: 2 Pages: 78-84
  • DOI: 10.1016/j.jdermsci.2021.03.006
  • Peer Reviewed / Open Access
• [Journal Article] A rare case of multiple pyoderma gangrenosum co-mobilized with pseudoxanthoma elasticum (2021)
  • Author(s): [Saki Iga,Atsushi Tanemura,Takumi Kamitani,Madoka Takafuji,Yuma Hanaoka,Noriko Arase,Manabu Fujimoto]
  • Journal Title: JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY Volume: 4 Issue: 3 Pages: 71-72
  • DOI: 10.1002/cia2.12159
  • Peer Reviewed / Open Access
• [Journal Article] A NOVEL AUTOANTIBODY AGAINST beta 2-GLYCOPROTEIN I/HLA CLASS II COMPLEXES IS A MAJOR RISK FACTOR FOR RECURRENT PREGNANCY LOSS (2021)
  • Author(s): [Kenji Tanimura,Shigeru Saito,Mikiya Nakatsuka,Takeshi Nagamatsu,Tomoyuki Fujii,Atsushi Fukui,Yuki Sasagawa,Masashi Deguchi,Noriko Arase,Hisashi Arase,Hideto Yamada]
  • Journal Title: PLACENTA Volume: 103 Pages: 253-254
  • Peer Reviewed
• [Journal Article] Use of a combination of oral psoralen, ultraviolet A and interferon-gamma for the treatment of mycosis fungoides during pregnancy, which probably evoked CD8(+)CD30(+)lymphoproliferative disorder (2021)
  • Author(s): [Kyoko Tonomura,Eiji Kiyohara,Yuya Nakanishi,Atsushi Tanemura,Noriko Arase,Yukinobu Nakagawa,Manabu Fujimoto]
  • Journal Title: JOURNAL OF DERMATOLOGY Volume: 48 Issue: 1
  • DOI: 10.1111/1346-8138.15628
  • Peer Reviewed
• [Journal Article] The beneficial effect of a PDE4 inhibitor in a patient with juvenile-onset intractable pityriasis rubra pilaris without CARD14 mutation (2021)
  • Author(s): [Emi Inoue,Noriko Arase,Yuma Hanaoka,Atsushi Tanemura,Manabu Fujimoto]
  • Journal Title: DERMATOLOGIC THERAPY Volume: 34 Issue: 1
  • DOI: 10.1111/dth.14714
  • Peer Reviewed / Open Access
• [Journal Article] Increased levels of plasma nucleotides in patients with rheumatoid arthritis (2020)
  • Author(s): Kishikawa T、Maeda Y、Nii T、Arase N、Hirata J、Suzuki K、Yamamoto K、Masuda T、Ogawa K、Tsuji S、Matsushita M、Matsuoka H、Yoshimura M、Tsunoda S、Ohshima S、Narazaki M、Ogata A、Saeki Y、Inohara H、Kumanogoh A、Takeda K、Okada Y
  • Journal Title: International Immunology Volume: 33 Issue: 2 Pages: 119-124
  • DOI: 10.1093/intimm/dxaa059
  • Peer Reviewed / Open Access
• [Journal Article] Local and disease control for nasal melanoma treated with radiation and concomitant anti‐programmed death 1 antibody (2020)
  • Author(s): Hanaoka Yuma、Tanemura Atsushi、Takafuji Madoka、Kiyohara Eiji、Arase Noriko、Suzuki Osamu、Isohashi Fumiaki、Ogawa Kazuhiko、Fujimoto Manabu
  • Journal Title: The Journal of Dermatology Volume: 47 Issue: 4 Pages: 423-425
  • DOI: 10.1111/1346-8138.15256
  • Peer Reviewed
• [Journal Article] Case of granuloma annulare after using tocilizumab (2020)
  • Author(s): [Kurumi Katsuda,Noriko Arase,Yukinobu Nakagawa,Atsushi Tanemura,Manabu Fujimoto]
  • Journal Title: JOURNAL OF DERMATOLOGY Volume: 47 Issue: 4
  • DOI: 10.1111/1346-8138.15252
  • Peer Reviewed
• [Journal Article] Genotype and phenotype analysis of patients with pediatric cutaneous mastocytosis, especially wild‐type KIT patients (2020)
  • Author(s): Arase Noriko、Wataya‐Kaneda Mari、Murota Hiroyuki、Nakagawa Yukinobu、Yamaoka Toshifumi、Itoi‐Ochi Saori、Hirayasu Kouyuki、Arase Hisashi、Fujimoto Manabu、Katayama Ichiro
  • Journal Title: The Journal of Dermatology Volume: 47 Issue: 4 Pages: 426-429
  • DOI: 10.1111/1346-8138.15266
  • Peer Reviewed
• [Journal Article] A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure (2020)
  • Author(s): Kume Miki、Nakagawa Yukinobu、Kiyohara Eiji、Arase Noriko、Wataya-Kaneda Mari、Yaga Moto、Yanagawa Masahiro、Fujimoto Manabu
  • Journal Title: Allergology International Volume: 20 Issue: 4 Pages: 30057-5
  • DOI: 10.1016/j.alit.2020.04.007
  • NAID: 130007926229
  • Peer Reviewed
• [Journal Article] Rare case of segmental vitiligo in which lesional enlargement occurred after suction blister transplantation (2020)
  • Author(s): [Kurumi Katsuda,Atsushi Tanemura,Madoka Takafuji,Yuma Hanaoka,Eiji Kiyohara,Noriko Arase,Manabu Fujimoto]
  • Journal Title: JOURNAL OF DERMATOLOGY Volume: 47 Issue: 9
  • DOI: 10.1111/1346-8138.15489
  • Peer Reviewed
• [Journal Article] Immunohistochemical analysis of rhododendrol-induced leukoderma in improved and aggravated cases (2020)
  • Author(s): [Masahito Yasuda,Akiko Sekiguchi,Chikako Kishi,Sayaka Toki,Noriko Arase,Aya Takahashi,Fei Yang,Atsushi Tanemura,Masahiro Hayashi,Yuko Abe,Toshihisa Hamada,Tamio Suzuki,Ichiro Katayama,Osamu Ishikawa]
  • Journal Title: JOURNAL OF DERMATOLOGICAL SCIENCE Volume: 99 Issue: 2 Pages: 140-143
  • DOI: 10.1016/j.jdermsci.2020.06.011
  • Peer Reviewed
• [Journal Article] The beta(2)-Glycoprotein I/HLA-DR Complex As A Major Autoantibody Target in Obstetric Antiphospholipid Syndrome (2020)
  • Author(s): [Kenji Tanimura,Shigeru Saito,Mikiya Nakatsuka,Takeshi Nagamatsu,Tomoyuki Fujii,Atsushi Fukui,Masashi Deguchi,Yuki Sasagawa,Noriko Arase,Hisashi Arase,Hideto Yamada]
  • Journal Title: ARTHRITIS & RHEUMATOLOGY Volume: 72 Issue: 11 Pages: 1882-1891
  • DOI: 10.1002/art.41410
  • Peer Reviewed
• [Journal Article] The first case of symmetrical acral keratoderma in Japan with filaggrin mutation who showed marked improvement in skin manifestations using moisturizer. (2020)
  • Author(s): Kazuya Akaji, Noriko Arase, Jin Teng Peh, Eiji Kiyohara, Hiroyuki Murota, Toshifumi Nomura, Manabu Fujimoto
  • Journal Title: The Journal of Dermatology Volume: in press Issue: 8
  • DOI: 10.1111/1346-8138.15410
  • Peer Reviewed
• [Journal Article] Achievement of remission with surgical resection of a lung adenocarcinoma without systemic treatment in a rare case of anti-TIF1-gamma antibody-positive dermatomyositis (2020)
  • Author(s): [Kyoko Tonomura,Yorihisa Kotobuki,Soichiro Funaki,Kurumi Katsuda,Noriko Arase,Eiji Kiyohara,Ikuko Ueda,Manabu Fujimoto]
  • Journal Title: JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY Volume: 3 Issue: 5 Pages: 117-119
  • DOI: 10.1002/cia2.12134
  • Peer Reviewed
• [Journal Article] An Optimized Crovalimab Dose and Regimen Reduced the Formation of Drug-Target-Drug Complexes in Patients with Paroxysmal Nocturnal Hemoglobinuria from the Phase I/II COMPOSER Trial (2020)
  • Author(s): [Jun-Ichi Nishimura,Antoine Soubret,Simon Buatois,Jean-Eric Charoin,Sasha Sreckovic,Christoph Bucher,Jules Hernandez-Sanchez,Gregor Jordan,Julia Ramos,Noriko Arase,Masaki Hotta,Yoshitaka Isaka,Yoshikazu Ito,Yuzuru Kanakura,Jin Seok Kim,Taroh Kinoshita,Eiichi Morii,et.al.]
  • Journal Title: BLOOD Volume: 136 Issue: Supplement 1 Pages: 2-3
  • DOI: 10.1182/blood-2020-136265
  • Peer Reviewed
• [Journal Article] Case of X‐linked hypohidrotic ectodermal dysplasia, along with facial bilateral reticular pigmentation (2020)
  • Author(s): Kamitani Tomo、Arase Noriko、Nomura Toshifumi、Peh Jin Teng、Katayama Ichiro、Wataya‐Kaneda Mari、Fujimoto Manabu
  • Journal Title: Journal of Cutaneous Immunology and Allergy Volume: 3 Issue: 2 Pages: 41-42
  • DOI: 10.1002/cia2.12097
  • Peer Reviewed / Open Access
• [Journal Article] A case of giant porokeratosis coexisting disseminated superficial porokeratosis (2020)
  • Author(s): [Saori Itoi-Ochi,Atsushi Tanemura,Noriko Arase,Manabu Fujimoto]
  • Journal Title: JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY Volume: 3 Issue: 6 Pages: 139-141
  • DOI: 10.1002/cia2.12141
  • Peer Reviewed
• [Journal Article] A case of drug‐induced hypersensitivity syndrome due to diaminodiphenyl sulfone complicated by acute respiratory failure with atypical erythema around existing prurigo (2020)
  • Author(s): Akaji Kazuya、Arase Noriko、Nakagawa Yukinobu、Tanemura Atsushi、Katayama Ichiro、Fujimoto Manabu
  • Journal Title: Journal of Cutaneous Immunology and Allergy Volume: 3 Issue: 2 Pages: 45-47
  • DOI: 10.1002/cia2.12106
  • Peer Reviewed / Open Access
• [Journal Article] Trial of Nemolizumab and Topical Agents for Atopic Dermatitis with Pruritus (2020)
  • Author(s): Kabashima K, Matsumura T, Komazaki H, Kawashima M; Nemolizumab-JP01 Study Group.
  • Journal Title: N Engl J Med. Volume: 383 Issue: 2 Pages: 141-150
  • DOI: 10.1056/nejmoa1917006
  • Peer Reviewed
• [Journal Article] Asian Case of Metastatic Melanoma in Which a Complete Response Was Maintained after Discontinuation of Dabrafenib and Trametinib (2020)
  • Author(s): Rikako Deno, Atsushi Tanemura, Madoka Takefuji, Yuma Hanaoka, Eiji Kiyohara, Noriko Arase, Mari Wataya-Kaneda, Manabu Fujimoto
  • Journal Title: Journal of Cosmetics, Dermatological Sciences and Applications Volume: 10
  • Peer Reviewed / Open Access
• [Journal Article] A case of zonisamide-induced toxic epidermal necrolysis with acute respiratory failure (2020)
  • Author(s): Kume, Miki, Nakagawa, Yukinobu, Kiyohara, Eiji, Arase, Noriko, KANEDA, MARI, Yaga, Moto, Yanagawa, Masahiro, Fujimoto, Manabu
  • Journal Title: Allergology International Volume: in press
  • NAID: 130007926229
  • Peer Reviewed
• [Journal Article] Expression of polydom in dermal neurofibroma and surrounding dermis in von Recklinghausen’s disease (2019)
  • Author(s): Kamitani Tomo、Murota Hiroyuki、Arase Noriko、Wataya-Kaneda Mari、Sato-Nishiuchi Ryoko、Sekiguchi Kiyotoshi、Okuzaki Daisuke、Motooka Daisuke、Katayama Ichiro
  • Journal Title: Journal of Dermatological Science Volume: 96 Issue: 2 Pages: 73-80
  • DOI: 10.1016/j.jdermsci.2019.09.005
  • Peer Reviewed / Open Access
• [Journal Article] Case of epidermolytic ichthyosis with impairment of pulmonary function and exacerbated skin manifestations in a late middle‐aged adult (2019)
  • Author(s): Maekawa Aya、Arase Noriko、Tamai Katsuto、Nomura Toshifumi、Kiyohara Eiji、Wataya‐Kaneda Mari、Arase Hisashi、Katayama Ichiro、Fujimoto Manabu
  • Journal Title: The Journal of Dermatology Volume: 46 Issue: 12 Pages: 480-482
  • DOI: 10.1111/1346-8138.15077
  • Peer Reviewed / Open Access
• [Journal Article] Rare case of Leydig cell tumor with type I diabetes mellitus causing female pattern hair loss (2019)
  • Author(s): Fukuda Miki、Arase Noriko、Otsuki Michio、Kuritani Kentaro、Hijiki Sachiko、Nojima Satoshi、Katayama Ichiro、Terao Mika、Inui Shigeki、Fujimoto Manabu
  • Journal Title: The Journal of Dermatology Volume: 46 Issue: 12
  • DOI: 10.1111/1346-8138.15050
  • Peer Reviewed
• [Journal Article] Autoantibodies detected in patients with vitiligo vulgaris but not in those with rhododendrol-induced leukoderma (2019)
  • Author(s): Arase Noriko,Tanemura Atsushi,Jin Hui,Nishioka Megumi,Aoyama Yumi,Oiso Naoki,Matsunaga Kayoko,Suzuki Tamio,Nishigori Chikako,Kawamura Tatsuyoshi,Shimizu Tadamichi,Ito Akiko,Fukai Kazuyoshi,Abe Yuko,Yang Lingli,Tsuruta Daisuke,et al
  • Journal Title: Journal of Dermatological Science Volume: 95 Issue: 2 Pages: 80-83
  • DOI: 10.1016/j.jdermsci.2019.06.009
  • Peer Reviewed
• [Journal Article] Transport of cellular misfolded proteins to the cell surface by HLA-B27 free heavy chain. (2019)
  • Author(s): Yorifuji H, Arase N, Kohyama M, Hirano T, Suenaga T, Kumanogoh A, Arase H.
  • Journal Title: Biochem Biophys Res Commun. Volume: 511 Issue: 4 Pages: 862-868
  • DOI: 10.1016/j.bbrc.2019.02.120
  • Peer Reviewed / Open Access
• [Journal Article] FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules. (2019)
  • Author(s): Shimizu Y, Kohyama M, Yorifuji H, Jin H, Arase N, Suenaga T, Arase H.
  • Journal Title: Int Immunol. Volume: Epub ahead of print Issue: 5 Pages: 303-314
  • DOI: 10.1093/intimm/dxz010
  • Peer Reviewed
• [Journal Article] Novel autoantibody against the β2-glycoprotein I/HLA-DR complex in patients with refractory cutaneous ulcers (2017)
  • Author(s): Arase N, Tanimura K, Jin H, Yamaoka T, Kishibe M, Nishioka M, Kiyohara E, Tani M, Matsuoka S, Ohmura K, Takasugi K, Yamamoto T, Murota H, Arase H, Katayama I.
  • Journal Title: Br J Dermatol. Volume: 印刷中 Issue: 1 Pages: 272-275
  • DOI: 10.1111/bjd.15571
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 抗MDA5抗体陽性皮膚筋炎の加療中に皮膚腺病を発症した１例 (2023)
  • Author(s): 秦野暢子、外村香子、木原俊輔、浅田充夫、山下千佳紗、石塚洋典、荒瀬規子、植田郁子、種村篤、藤本学、平田陽彦、五十嵐謙人、山本剛、木村優香、片岡葉子
  • Organizer: 第496回大阪地方会
• [Presentation] TMC6に変異を認め進行有棘細胞癌を生じた疣贅状表皮発育異常症の1例 (2022)
  • Author(s): 藤本 萌、横井一範、黒神 祐、外村香子、荒瀬規子、種村 篤、藤本 学、新保敬史、玉井克人
  • Organizer: 第73回皮膚科学会中部支部
• [Presentation] 造血幹細胞移植後に生じたerosive pustular dermatosis of the scalpの1例 (2022)
  • Author(s): 山下千佳紗、荒瀬規子、坂井浩志、藤本 学
  • Organizer: 日本皮膚科学会 第115回近畿皮膚科集談会
• [Presentation] DPP-4阻害薬服用中に発症した抗α6β4インテグリン抗体陽性水疱性類天疱瘡の1例 (2021)
  • Author(s): 山下千佳紗、荒瀬規子、種村篤、野島聡、藤本学
  • Organizer: 第51回日本皮膚免疫アレルギー学会総会学術大会
• [Presentation] An infectivity-enhancing site on the SARS-Cov-2 spike protein targeted by antibodies (2021)
  • Author(s): Yafei Liu, Wataru Nakai, Noriko Arase, Masako Kohyama, Hisashi Arase
  • Organizer: The 50th Annual Meeting of The Japanese Society for Immunology
• [Presentation] Plasma metabolome-wide analysis in Japanese identifies potential biomarkers of psoriasis and clinical subtypes (2021)
  • Author(s): Yukinori Okada, Toshihiro Kishikawa, Noriko Arase, Shigeyoshi Tsuji, Yuichi Maeda, Takuro Nii, Jun Hirata, Ken Suzuki, Kenichi Yamamoto, Shiro Ohshima, Hidenori Inohara, Atsushi Kumanogoh, Manabu Fujimoto
  • Organizer: The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] ヘパリン類似物質が奏功した symmetrical acral keratoderma の1例 (2020)
  • Author(s): 赤路和哉、荒瀬規子、Peh Jin Teng、清原英司、室田浩之、乃村俊史、藤本 学
  • Organizer: 第84回日本皮膚科学会東部支部学術大会
• [Presentation] アプレミラストが奏効した若年性毛孔性紅色粃糠疹の1例 (2020)
  • Author(s): 井上栄美、荒瀬規子、花岡佑真、種村 篤、藤本 学
  • Organizer: 第84回日本皮膚科学会東京支部学術大会
• [Presentation] An Optimized Crovalimab Dose and Regimen Reduced the Formation of Drug-Target-Drug Complexes in Patients with Paroxysmal Nocturnal Hemoglobinuria From the Phase I/II COMPOSER Trial. (2020)
  • Author(s): Jun-ichi Nishimura, Antoine Soubret, Simon Buatois, Jean-Eric Charoin, Sasha Sreckovic, Christoph Bucher, Jules Hernandez-Sanchez, Gregor Jordan, Julia Ramos, Noriko Arase, Masaki Hotta, Yoshitaka Isaka, Yoshikazu Ito, Yuzuru Kanakura, Jin Seok Kim, Taroh Kinoshita, Eiichi Morii, et.al.
  • Organizer: 62nd Ash Annual Meeting and Exposition
  • Int'l Joint Research
• [Presentation] 視神経脊髄炎に対してトシリズマブ使用後に環状肉芽腫を発症した１例 (2019)
  • Author(s): 勝田来未、荒瀬規子、中川幸延、種村 篤、藤本 学
  • Organizer: 第71回日本皮膚科学会西部支部学術大会
• [Presentation] 結節性痒疹治療中に急性呼吸不全を呈したDIHSの一例 (2019)
  • Author(s): 赤路 和哉、荒瀬 規子、中川 幸延、片山 一朗、藤本 学
  • Organizer: 第49回日本皮膚免疫アレルギー学会総会学術大会
• [Presentation] 呼吸障害を併発したゾニサミドによる中毒性表皮壊死症の１例 (2019)
  • Author(s): 福田美輝、中川幸延、清原英司、 荒瀬規子、金田眞理、藤本学
  • Organizer: 第49回日本皮膚免疫アレルギー学会総会学術大会
• [Presentation] ミスフォールド蛋白質/MHCクラスII複合体 (2019)
  • Author(s): 荒瀬規子
  • Organizer: 第47回日本臨床免疫学会総会
  • Invited
• [Presentation] Analysis of autoantibody against Ro52/IgG/HLA-DR complex in patients with Dermatomyositis (2019)
  • Author(s): Noriko Arase, Kaori Odomari, Yorihisa Kotobuki, Hideaki Tsuji, Ran Sasai, Toru Hirano, Hideki Yorifuji, Kyoko Tonomura, Ichiro Katayama, Hiroyuki Murota, Hui Jin, Koichiro Ohmura, Atsushi Kumanogoh, Hisashi Arase, Manabu Fujimoto
  • Organizer: 日本研究皮膚科学会 第44回年次学術大会・総会
• [Presentation] Female pattern hair loss (FPHL)を呈した１型糖尿病合併ライディッヒ細胞腫の1例 (2019)
  • Author(s): 福田美輝、荒瀬規子、片山一朗、寺尾美香、乾重樹、藤本学
  • Organizer: 第24回日本臨床毛髪学会学術集会
• [Presentation] MHCクラスⅡ分子によるDNAの提示 (2019)
  • Author(s): 辻 英輝、大村 浩一郎、荒瀬 規子、香山 雅子、榊原 修平、菊谷 仁、末永 忠広、三森 経世、荒瀬 尚
  • Organizer: 第29 回Kyoto T cell Conference
• [Presentation] TSHR / MHC class II complexes are involved in the pathogenesis of Graves' disease (2019)
  • Author(s): Hui Jin, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Takehiko Sasazuki, Hisashi Arase
  • Organizer: 第18回あわじ感染と免疫フォーラム
• [Presentation] FcγRIIIA-mediated activation of NK cells by IgG heavy chain complexed with MHC class II molecules (2019)
  • Author(s): Tadahiro Suenaga, Yuta Shimizu, Masako Kohyama, Hideki Yorifuji, Jin Hui, Noriko Arase, Hisashi Arase
  • Organizer: 第48回日本免疫学会学術集会
• [Presentation] 大阪大学皮膚科における皮膚肥満細胞増多症16症例の解析 (2018)
  • Author(s): 荒瀬規子 金田眞理 室田浩之 中川幸延 山岡俊文 平安恒幸 荒瀬 尚 片山一朗
  • Organizer: 日本皮膚科学会総会
• [Presentation] 壮年期に肺機能障害を伴い皮疹が悪化 した表皮融解性魚鱗癬に関する考察 (2018)
  • Author(s): 前川亜耶 荒瀬規子 清原英司 玉井克人 片山一朗 金田眞理
  • Organizer: 日本皮膚科学会東部支部学術集会
• [Presentation] Recognition of DNA/HLA-class II complex by anti-DNA antibodies from SLE patients (2018)
  • Author(s): Hideki Tsuji, Koichiro Ohmura, Shuhei Sakakibara, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Hitoshi Kikutani, Tsuneyo Mimori, Hisashi Arase
  • Organizer: 日本免疫学会学術集会
• [Presentation] TSHR-stimulating autoantibody production by TSHR/MHC class II complexes (2018)
  • Author(s): Hui Hin, Noriko Arase, Masako Kohyama, Tadahiro Suenaga, Takehiko Sasazuki, Hisashi Arase
  • Organizer: 日本免疫学会学術集会
• [Book] 皮膚科 ベストセレクション 皮膚科 膠原病 (2021)
  • Author(s): 荒瀬規子、荒瀬尚
  • Total Pages: 515
  • Publisher: 中山書店
  • ISBN: 9784521748627