How do tissue resident memory T cells induce the local recurrence of atopic dermatitis
| Project/Area Number |
18K08297
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Tottori University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 組織常在性記憶T細胞 / ヘルパーT細胞 / アトピー性皮膚炎 / 接触性皮膚炎 / 皮膚局所の免疫記憶 / 接触過敏症 / 表皮ｇamma-delta T細胞 |
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| Outline of Final Research Achievements |
In this study, we investigated the mechanism of repeated relapses and remissions of allergic skin diseases such as atopic dermatitis in the same area using a mouse model of dermatitis. We found that in addition to killer T cells, a large number of helper T cells remained in the dermis as memory T cells in the inflammation-healed skin. Each of these memory T cells formed 'local skin immune memory' and locally increased reactivity to allergens of the skin. Moreover, while memory killer T cells disappeared from the inflammation-experienced skin within 1 year after healing, memory helper T cells continued to be maintained during this period. Thus, these results indicate that helper memory T cells, which remain in the inflammation-experienced skin, are one of the cause of the recurrence of inflammatory skin diseases.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究から、炎症を経験した皮膚に形成される局所の免疫記憶は、皮膚に留まり続ける記憶ヘルパーT細胞が長期間維持することが分かった。よって、炎症性皮膚疾患の再発を根治するためには、患部から記憶ヘルパーT細胞を除去することで皮膚局所の免疫記憶を解消する必要があると示唆された。ステロイド剤の塗布等による治療では、症状が改善しても塗布を中止するとしばしば同じ部位で再発することから、既存の方法では皮膚局所の免疫記憶は除去できないと考えられる。今後、本研究の成果を元に、皮膚で記憶ヘルパーT細胞が維持される仕組みが明らかになり、その分子機構を標的とした皮膚疾患再発の根本治療法が開発されることが期待される。
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Overexpression of miR-669m inhibits erythroblast differentiation2020
Author(s)
Kotaki R., et.al. Kawashima M, Yamaguchi A, Suzuki N, Koyama-Nasu R, Ogiya D, Okuyama K, Yamamoto Y, Takamatsu M, Kurosaki N, Ando K, Murata A, Ohtsuka M, Nakagawa S, Katagiri K, Kotani A.
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Journal Title
Sci Rep.
Volume: 10
Issue: 1
Pages: 13554-13554
DOI
Related Report
Peer Reviewed / Open Access
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