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circular RNA in fibrotic skin disease

Research Project

Project/Area Number 18K08307
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53050:Dermatology-related
Research InstitutionWakayama Medical University

Principal Investigator

Jinnin Masatoshi  和歌山県立医科大学, 医学部, 教授 (60401048)

Project Period (FY) 2018-04-01 – 2021-03-31
Project Status Completed (Fiscal Year 2020)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords強皮症 / 膠原病 / 全身性強皮症 / rna
Outline of Final Research Achievements

We performed array analysis using cultured fibroblasts derived from scleroderma skin, and focused on a cyclic RNA (X) as a circular RNA that has more than 50 reads and can be detected by the taqman system. When the circular RNA(X) was forcibly expressed in normal fibroblasts using a lentivirus, the protein expression of type I collagen and CTGF was suppressed.
In addition, we extracted RNA from serum and tried to confirm whether the circular RNA(X) was actually expressed in serum by real-time PCR using a small number of samples, but there was no amplification and we could not detect the RNA in serum in our experimental system.

Academic Significance and Societal Importance of the Research Achievements

本研究計画の意義としては病態の解明のみならず、皮膚組織で特異的環状RNAを検出する事で各疾患の診断や病勢の評価ができれば、より鋭敏な全く新しい疾患マーカーの開発につながる創造性が存在する。さらに、マウスモデルを用いて環状RNAを特異的に補充あるいは阻害する事で皮膚線維化が抑制出来ることを証明出来れば、新規治療の開発につながる。社会へ与えるインパクトとして、膠原病の病態解明・診断・治療法の開発は医学全体における長年の課題であった。膠原病を含むいわゆる難病の原因解明は国民の健康増進に大きく寄与するとともに難病に対する社会の考え方を大きく変えることができる。

Report

(4 results)
  • 2020 Annual Research Report   Final Research Report ( PDF )
  • 2019 Research-status Report
  • 2018 Research-status Report
  • Research Products

    (15 results)

All 2020 2019 2018 2017

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 4 results) Presentation (2 results) (of which Invited: 1 results)

  • [Journal Article] Up-regulation of IGF-1, RANTES and VEGF in patients with anti-centromere antibody-positive early/mild systemic sclerosis2020

    • Author(s)
      Tabata Kayoko、Mikita Naoya、Yasutake Misaki、Matsumiya Ryo、Tanaka Katsunori、Tani Sayaka、Okuhira Hisako、Jinnin Masatoshi、Fujii Takao
    • Journal Title

      Modern Rheumatology

      Volume: - Issue: 1 Pages: 1-6

    • DOI

      10.1080/14397595.2020.1726599

    • Related Report
      2019 Research-status Report
    • Peer Reviewed
  • [Journal Article] A potential significance of circ_0024169 down regulation in angiosarcoma tissue2019

    • Author(s)
      Nakashima S, Jinnin M, Ide M, Kajihara I, Igata T, Harada M, Masuguchi S, Fukushima S, Masuzawa M, Masuzawa M, Amoh Y, Ihn H.
    • Journal Title

      Intractable & Rare Diseases Research

      Volume: 8 Issue: 2 Pages: 129-133

    • DOI

      10.5582/irdr.2019.01034

    • NAID

      130007663175

    • ISSN
      2186-361X, 2186-3644
    • Year and Date
      2019-05-31
    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] First external validation of sensitivity and specificity of the European League Against Rheumatism (EULAR)/American College of Rheumatology (ACR) classification criteria for idiopathic inflammatory myopathies with a Japanese cohort2019

    • Author(s)
      Jinnin Masatoshi、Ohta Akiko、Ishihara Shoichiro、Amano Hirofumi、Atsumi Tatsuya、Fujimoto Manabu、Kanda Takashi、Kawaguchi Yasushi、Kawakami Atsushi、Mimori Akio、Mimori Tsuneyo、Mimura Toshihide、Muro Yoshinao、Sano Hajime、Shimizu Jun、et al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 79 Issue: 3 Pages: 387-392

    • DOI

      10.1136/annrheumdis-2019-215488

    • Related Report
      2019 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Peripheral blood eosinophilia is associated with the presence of skin ulcers in patients with systemic sclerosis2019

    • Author(s)
      Hara Tomoyuki、Ikeda Takaharu、Inaba Yutaka、Kunimoto Kayo、Mikita Naoya、Kaminaka Chikako、Kanazawa Nobuo、Yamamoto Yuki、Tabata Kayoko、Fujii Takao、Jinnin Masatoshi
    • Journal Title

      The Journal of Dermatology

      Volume: 46 Issue: 4 Pages: 334-337

    • DOI

      10.1111/1346-8138.14774

    • Related Report
      2019 Research-status Report 2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment consensus for management of polymyositis and dermatomyositis among rheumatologists, neurologists and dermatologists2018

    • Author(s)
      Kohsaka Hitoshi、Mimori Tsuneyo、Kanda Takashi、Shimizu Jun、Sunada Yoshihide、Fujimoto Manabu、Kawaguchi Yasushi、Jinnin Masatoshi、Muro Yoshinao、Ishihara Shoichiro、Tomimitsu Hiroyuki、Ohta Akiko、Sumida Takayuki
    • Journal Title

      Modern Rheumatology

      Volume: 29 Issue: 1 Pages: 1-19

    • DOI

      10.1080/14397595.2018.1521185

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment consensus for management of polymyositis and dermatomyositis among rheumatologists, neurologists and dermatologists2018

    • Author(s)
      Kohsaka Hitoshi、Mimori Tsuneyo、Kanda Takashi、Shimizu Jun、Sunada Yoshihide、Fujimoto Manabu、Kawaguchi Yasushi、Jinnin Masatoshi、Muro Yoshinao、Ishihara Shoichiro、Tomimitsu Hiroyuki、Ohta Akiko、Sumida Takayuki
    • Journal Title

      The Journal of Dermatology

      Volume: 46 Issue: 1

    • DOI

      10.1111/1346-8138.14604

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic criteria, severity classification and guidelines of localized scleroderma2018

    • Author(s)
      Asano Yoshihide、Fujimoto Manabu、Ishikawa Osamu、Sato Shinichi、Jinnin Masatoshi、Takehara Kazuhiko、Hasegawa Minoru、Yamamoto Toshiyuki、Ihn Hironobu
    • Journal Title

      The Journal of Dermatology

      Volume: 45 Issue: 7 Pages: 755-780

    • DOI

      10.1111/1346-8138.14161

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic criteria, severity classification and guidelines of systemic sclerosis2018

    • Author(s)
      Asano Yoshihide、Jinnin Masatoshi、Kawaguchi Yasushi、Kuwana Masataka、Goto Daisuke、Sato Shinichi、Takehara Kazuhiko、Hatano Masaru、Fujimoto Manabu、Mugii Naoki、Ihn Hironobu
    • Journal Title

      The Journal of Dermatology

      Volume: 45 Issue: 6 Pages: 633-691

    • DOI

      10.1111/1346-8138.14162

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of a new simplified disability scoring system for adult patients with localized scleroderma2018

    • Author(s)
      Okiyama Naoko、Asano Yoshihide、Hamaguchi Yasuhito、Jinnin Masatoshi、Motegi Sei-ichiro、Koizumi Haruka、Hasegawa Minoru、Ishikawa Osamu、Sato Shinichi、Takehara Kazuhiko、Yamamoto Toshiyuki、Fujimoto Manabu、Ihn Hironobu
    • Journal Title

      The Journal of Dermatology

      Volume: 45 Issue: 4 Pages: 431-435

    • DOI

      10.1111/1346-8138.14214

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regulatory mechanisms of collagen expression by interleukin-22 signaling in scleroderma fibroblasts2018

    • Author(s)
      Sawamura Soichiro、Jinnin Masatoshi、Inoue Kuniko、Yamane Keitaro、Honda Noritoshi、Kajihara Ikko、Makino Takamitsu、Masuguchi Shinichi、Fukushima Satoshi、Ihn Hironobu
    • Journal Title

      J Dermatol Sci.

      Volume: 90 Issue: 1 Pages: 52-59

    • DOI

      10.1016/j.jdermsci.2017.12.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Splicing variant ofWDFY4augments MDA5 signalling and the risk of clinically amyopathic dermatomyositis2018

    • Author(s)
      Kochi Yuta et al.
    • Journal Title

      Annals of the Rheumatic Diseases

      Volume: 77 Issue: 4 Pages: 602-611

    • DOI

      10.1136/annrheumdis-2017-212149

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnostic criteria, severity classification and guideline of lichen sclerosus et atrophicus2017

    • Author(s)
      Hasegawa Minoru、Ishikawa Osamu、Asano Yoshihide、Sato Shinichi、Jinnin Masatoshi、Takehara Kazuhiko、Fujimoto Manabu、Yamamoto Toshiyuki、Ihn Hironobu、for the Executive Committee of Guideline
    • Journal Title

      The Journal of Dermatology

      Volume: 印刷中 Issue: 8 Pages: 891-897

    • DOI

      10.1111/1346-8138.14171

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Guideline for diagnostic criteria, severity classification and treatment of eosinophilic fasciitis2017

    • Author(s)
      Jinnin Masatoshi、Yamamoto Toshiyuki、Asano Yoshihide、Ishikawa Osamu、Sato Shinichi、Takehara Kazuhiko、Hasegawa Minoru、Fujimoto Manabu、Ihn Hironobu
    • Journal Title

      The Journal of Dermatology

      Volume: 印刷中 Issue: 8 Pages: 881-890

    • DOI

      10.1111/1346-8138.14160

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Presentation] 全身性強皮症患者における血清コラーゲンDNA量の検討2019

    • Author(s)
      神人正寿
    • Organizer
      エラスチン研究会
    • Related Report
      2019 Research-status Report
  • [Presentation] 強皮症に伴う潰瘍に対するエキソソームの治療応用2018

    • Author(s)
      神人
    • Organizer
      日本皮膚免疫アレルギー学会
    • Related Report
      2018 Research-status Report
    • Invited

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Published: 2018-04-23   Modified: 2022-01-27  

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