| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
We are engaged in research using dermal sheath cup cells (DSCC) in the field of hair regenerative medicine. It is a breakthrough cell therapy with the potential to provide new treatment options for patients with androgenetic alopecia. We have identified Gremlin (GREM) as a gene that is specifically expressed in the DSC. Investigation of the mRNA expression levels of GREM by in situ hybridization revealed localization of GREM2 in the DSC, with no expression in the middle-portion (extending to the bulge) of the hair follicle. Expression of GREM2 in the DSC was observed at different stages of the hair cycle, even during the anagen and catagen phases, and even in miniaturized follicles that were almost one-half of their original size.
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